A5028861640- Cell Image Analysis Techniques
- Single-cell and spatial transcriptomics
- Angiogenesis and VEGF in Cancer
King's College London
2020-2022
Guy's Hospital
2020-2022
Endothelial cells (ECs) are heterogeneous across and within tissues, reflecting distinct, specialised functions. EC heterogeneity has been proposed to underpin plasticity independently from vessel microenvironments. However, driven by contact-dependent or short-range cell-cell crosstalk cannot be evaluated with single cell transcriptomic approaches, as spatial contextual information is lost. Nonetheless, quantification of understanding its molecular drivers key developing novel therapeutics...
Abstract Endothelial cells (EC) are heterogeneous across and within tissues, reflecting distinct, specialised functions. EC heterogeneity has been proposed to underpin plasticity independently from vessel microenvironments. However, driven by contact-dependent or short-range cell-cell crosstalk cannot be evaluated with single cell transcriptomic approaches as spatial contextual information is lost. Nonetheless, quantification of understanding its molecular drivers key developing novel...