A5102761718- Hip and Femur Fractures
- T-cell and B-cell Immunology
- Pelvic and Acetabular Injuries
- Immunotherapy and Immune Responses
- Hip disorders and treatments
- Bone fractures and treatments
- Orthopaedic implants and arthroplasty
- Cardiac, Anesthesia and Surgical Outcomes
- Orthopedic Surgery and Rehabilitation
- Multiple Sclerosis Research Studies
- Sports injuries and prevention
- Total Knee Arthroplasty Outcomes
- Prosthetics and Rehabilitation Robotics
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- Ocular Oncology and Treatments
- Ocular Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Cytokine Signaling Pathways and Interactions
- Anesthesia and Neurotoxicity Research
- Shoulder and Clavicle Injuries
- Musculoskeletal Disorders and Rehabilitation
- Shoulder Injury and Treatment
- Spinal Cord Injury Research
Vanderbilt University Medical Center
2021-2022
University of Pennsylvania
2017-2022
HCA Healthcare
2022
University of Michigan
2022
The University of Texas Southwestern Medical Center
2010-2013
Southwestern Medical Center
2011-2013
Harvard University
2006
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the CNS, and CD8 T cells are predominant cell population in MS lesions. Given that transfer CNS-specific results attenuated clinical C57BL/6 mice with immunization-induced experimental autoimmune encephalomyelitis (EAE), we investigated cellular targets mechanisms autoreactive regulatory cells. In this study report myelin oligodendrocyte glycoprotein peptide (MOG35-55)-induced could also attenuate adoptively transferred,...
OBJECTIVES: To compare outcomes and complications between nonoperative operative management of femur tibia fractures in patients with paraplegia or quadriplegia from chronic spinal cord injury (SCI). METHODS: Design: Retrospective cohort study. Setting: Three Level-1 Trauma centers. Patient Selection Criteria: All adult due to a SCI treatment femoral tibial shaft fracture January 1, 2009 through December 31, 2019 were included. Outcome Measures Comparisons: Outcomes collected included range...
Controversy continues regarding appropriate indications for posterior malleolus fracture fixation in unstable rotational trimalleolar ankle injuries, with limited data comparing gait operatively treated fractures vs control populations. The purpose of this study was to evaluate the effect on parameters early postoperative period as compared a healthy population.Adult patients having undergone operative treatment isolated were eligible inclusion. A total 10 met inclusion criteria and...
Objective: To characterize the associated injuries, fixation constructs, and outcomes of extra-articular unstable iliac fractures. Design: Retrospective cohort study. Setting: Level I trauma center. Patients: Thirty-three fractures treated over a 20-year period. Intervention: Percutaneous or open at pelvic brim AND/OR crest. Main Outcome Measures: Incidence union, failure, angiography time injury. Results: Twenty-five patients were operatively with appropriate follow-up. Four had failure...
To characterize the associated injuries, fixation constructs, and outcomes of extra-articular unstable iliac fractures.Retrospective cohort study.Level I trauma center.Thirty-three fractures treated over a 20-year period.Percutaneous or open at pelvic brim AND/OR crest.Incidence union, failure, angiography time injury.Twenty-five patients were operatively with appropriate follow-up. Four had failure displacement, all in group only OR crest (4/8 patients, 50% rate). In both AND (n = 17),...
Periprosthetic tibial shaft fractures below total knee arthroplasty (TKA) are relatively rare, with an incidence of approximately 1%. However, as the rates increase, orthopaedic surgeons likely to see a corresponding increase in these types fractures. Native routinely treated either nails or plates, and success intramedullary nailing has been well described literature. In this article, we seek describe case series patients ipsilateral TKA infrapatellar nailing. We will focus on preoperative...
The bloodless removal by electrocoagulation of a large tumor, so vascular that several attempts at surgical had failed because hemorrhage, indicates the value this method. tumor was large. It is only one size, attached to side face, reported in literature. History. —Miss A. M., an unmarried white woman, aged 33, complained on right face. patient stated instrumental delivery birth resulted injury eye and deformity orbit. At 3 months age, removed account festering eyeball. 4 years late Dr....
Abstract Immune dysregulation is believed to be the causative factor in debilitating neurological disease Multiple Sclerosis (MS). We have recently shown that neuroantigen-specific auto-reactive regulatory (autoregulatory) CD8+ T-cells are capable of suppressing murine model MS, experimental autoimmune encephalomyelitis (EAE), a mediated by CD4+ T-cells. now show deficiency correlates with more severe and an increase IL-17+ TCRVβ8.2+ T-cell responses reduction IL-10+ Disease suppression...
Abstract Multiple Sclerosis (MS) is an inflammatory demyelinating disease with a preponderance of CD8 T-cells in central nervous system (CNS) lesions. We have previously shown that myelin-specific autoreactive are capable suppressing MOG35-55 peptide-induced experimental autoimmune encephalomyelitis (EAE), murine model MS. now report can suppress CD4 T-cell-mediated EAE disease. Whereas CD8-/- mice, increased severity was associated autoreactivity and cytokine production by T-cells, the...
The opioid epidemic in the United States has forced care providers to seek out alternatives narcotic analgesics. Physicians involved trauma care, including orthopaedic surgeons, often have patients requiring significant amounts of these medications, especially perioperative period, given acuity and severity their injuries. Modalities such as local infiltration fractures with anesthetic agents during operative treatment may provide some benefit this population by decreasing postoperative pain...