A5065354304- Connexins and lens biology
- Photoreceptor and optogenetics research
- Marine Invertebrate Physiology and Ecology
- Monoclonal and Polyclonal Antibodies Research
- Plant and Biological Electrophysiology Studies
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Protist diversity and phylogeny
- Microtubule and mitosis dynamics
University of Bergen
2022-2023
Oslo University Hospital
2023
A fundamental breakthrough in neurobiology has been the formulation of neuron doctrine by Santiago Ramón y Cajal, which stated that nervous system is composed discrete cells. Electron microscopy later confirmed and allowed identification synaptic connections. In this work, we used volume electron three-dimensional reconstructions to characterize nerve net a ctenophore, marine invertebrate belongs one earliest-branching animal lineages. We found neurons subepithelial have continuous plasma...
Summary A fundamental breakthrough in neurobiology has been the formulation of neuron doctrine by Santiago Ramón y Cajal, which states that nervous system is composed discrete individual cells. Electron microscopy later confirmed and allowed identification synaptic connections. Here we use volume electron 3D reconstructions to characterize nerve net a cydippid-phase ctenophore, belonging one earliest-branching animal lineages. We found neurons its subepithelial do not follow Cajal’s but...
Abstract Antibody-drug conjugates (ADCs) have demonstrated impressive activity in recent clinical trials breast cancer. Such targeted therapeutics strongly depends on the presence of target molecules tumor cells, and such may determine response ADCs. However, ADCs are also dependent cellular uptake, factors regulating endocytosis as well intracellular trafficking influence ADC activity. We recently that HER2 trastuzumab emtansine (T-DM1) is expression RAB5A, a protein (1). A significant...