Marked disparities exist across healthy individuals in their ability to imagine scenes, recall autobiographical memories, think about the future and navigate world. The importance of hippocampus supporting these critical cognitive functions has prompted question whether differences hippocampal grey matter volume could be one source performance variability. Evidence date been somewhat mixed. In this study we sought mitigate issues that commonly affect types studies. Data were collected from a...

The hippocampus is linked with both sleep and memory, but there debate about whether a salient aspect of - dreaming requires its input. To address this question, we investigated if human patients focal bilateral hippocampal damage amnesia engaged in dreaming. We employed provoked awakening protocol where participants were woken up at various points throughout the night, including during non-rapid eye movement rapid sleep, to report their thoughts that moment. Despite being roused similar...

Autobiographical memory, future thinking, and spatial navigation are critical cognitive functions that thought to be related known depend upon a brain structure called the hippocampus.Surprisingly, direct evidence for their interrelatedness is lacking, as an understanding of why they might related.There debate about whether linked by underlying memory-related process or, has more recently been suggested, because each require endogenous construction scene imagery.Here, using large sample...

The hippocampus plays a critical role in sleep-related memory processes [1-3], but it is unclear which specific sleep features are dependent upon this brain structure. examination of physiology patients with focal bilateral hippocampal damage and amnesia could supply important evidence regarding these links. However, there dearth such studies, despite providing compelling insights into awake cognition [4, 5]. Here, we sought to identify the contribution phenotype by characterizing via...

Recent studies highlight a critical role of the human lateral occipitotemporal cortex (LOTC) in action understanding, particularly how we perceive and interpret movements interactions with tools bodies. This region, along connected fronto-parietal areas, has been implicated limb apraxia, disorder that affects skilled movement after stroke. In this study, focused on whether there were any changes brain activity or connectivity areas involving LOTC its interconnected perceptuo-motor network...

Detecting subtle indicators of trustworthiness is highly adaptive for moving effectively amongst social partners. One powerful signal gaze direction, which individuals can use to inform (or deceive) by looking toward away from) important objects or events in the environment. Here, across 5 experiments, we investigate whether implicit learning about cues influence subsequent economic transactions; also examine some underlying mechanisms. In 1st experiment, demonstrate that people invest more...

Selective attention allows us to prioritize the processing of relevant information and filter out irrelevant information. Human functional neuroimaging lesion-based studies have highlighted fronto-parietal dorsal network (DAN) as an important in this process. In study, we investigated role DAN distracter suppression by dynamically modifying priority visual (target > high low distracter) based on features only. To end, collected fMRI data 24 healthy subjects, who performed a feature-based...

Limb apraxia is a syndrome often observed after stroke that affects the ability to perform skilled actions despite intact elementary motor and sensory systems. In large cohort of unselected patients with lesions left, right, bilateral hemispheres, we used voxel-based lesion-symptom mapping (VLSM) on clinical CT head images identify neuroanatomical correlates impairment performance in three tasks investigating praxis skills patient populations. These included meaningless gesture imitation...

Previous studies have shown that hand actions to visual object are affected both by perceptual factors and action goals. Our aim was study how these processes in chronic stroke patients, based on whether they had limb apraxia. Twenty-two Left Hemisphere, were measured neuropsychological tasks of apraxia, which identified a subgroup ten patients. All patients underwent testing separate task making simple reach grasp cup. Their performance compared group 18 healthy age-matched volunteers....

We assessed the factors influencing planning of actions required to manipulate one two everyday objects with matching dimensions but openings at opposite ends: a cup and vase. found that, for cups, measures movement preparation reach grasp object were influenced by whether was made functional part (wide opening) action would end in supinated as opposed pronated grasp. These interacted such that effects hand posture only when less familiar non-functional (the base). not vase, which has...

Abstract Autobiographical memory, future thinking and spatial navigation are critical cognitive functions that thought to be related, known depend upon a brain structure called the hippocampus. Surprisingly, direct evidence for their interrelatedness is lacking, as an understanding of why they might related. There debate about whether linked by underlying memory-related process or, has more recently been suggested, because each require endogenous construction scene imagery. Here, using large...

Limb apraxia is a higher-order motor disorder often occurring post-stroke, which affects skilled actions. It assessed through tasks involving gesture production or pantomime, recognition, meaningless imitation, complex figure drawing, single and multi-object use. A two-system model for the organisation of actions hypothesizes distinct pathways mediating praxis deficits via conceptual, 'indirect', perceptual 'direct' routes to action. Traditional lesion- symptom mapping techniques have failed...

<title>Abstract</title> Limb apraxia is an acquired higher-order motor disorder affecting skilful actions, often observed following a stroke. It assessed on tasks involving gesture production, recognition, imitation, object use, and multi-object sequencing. A two-system model for the organisation of action has been hypothesised based errors patients make these tasks. This distinguishes between deficits conceptualising actions mediated by ‘indirect’ route to action, in implementing via...

Limb apraxia is a syndrome that affects the ability to perform skilful actions, despite intact elementary motor and sensory systems. Using voxel-based lesion symptom mapping in large cohort of 387 stroke patients we determined neuroanatomy three tasks traditionally used study praxis skills patient populations: these included meaningless gesture imitation task, production task involving pantomime transitive intransitive gestures recognition same categories gestures. Lesions associated with...

Abstract Marked disparities exist across healthy individuals in their ability to imagine scenes, recall autobiographical memories, think about the future and navigate world. The importance of hippocampus supporting these critical cognitive functions has prompted question whether differences hippocampal grey matter volume could be one source performance variability. Evidence date been somewhat mixed. In this study we sought mitigate issues that commonly affect types studies. Data were...

Abstract Limb apraxia, a disorder of skilled action not consequent on primary motor or sensory deficits, has traditionally been defined according to errors patients make neuropsychological tasks. Previous models the have failed provide unified account patients’ due heterogeneity in and tasks used. In this study we implemented principal component analysis (PCA) elucidate core factors cohort 41 unselected left hemisphere chronic stroke who were tested comprehensive validated apraxia screen....