Michele Ferreira da Silva Mela

ORCID: 0000-0002-3587-351X
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About
Contact & Profiles
Research Areas
  • Chemical synthesis and pharmacological studies
  • Synthesis and biological activity
  • Research on Leishmaniasis Studies

Universidade Estadual Paulista (Unesp)
2022

Leishmaniasis is a highly prevalent, yet neglected disease caused by protozoan parasites of the genus Leishmania. In search for newer, safer, and more effective antileishmanial compounds, we herein present study mode action in addition to detailed structural biological characterization LQOF-G6 [N-benzoyl-N'-benzyl-N″-(4-tertbutylphenyl)guanidine]. X-ray crystallography extensive NMR experiments revealed that nearly exclusively adopts Z conformation stabilized an intramolecular hydrogen bond....

10.3390/biom12121903 article EN cc-by Biomolecules 2022-12-19
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