A5088120291- Angiogenesis and VEGF in Cancer
- Atherosclerosis and Cardiovascular Diseases
- Adipose Tissue and Metabolism
- Protease and Inhibitor Mechanisms
- Biomarkers in Disease Mechanisms
- Retinal Diseases and Treatments
- Wound Healing and Treatments
- Endoplasmic Reticulum Stress and Disease
- Metabolism, Diabetes, and Cancer
- Single-cell and spatial transcriptomics
- Diabetic Foot Ulcer Assessment and Management
- Mitochondrial Function and Pathology
- Cell Adhesion Molecules Research
- Cholesterol and Lipid Metabolism
- Glycosylation and Glycoproteins Research
- Pancreatic function and diabetes
- Peroxisome Proliferator-Activated Receptors
- Innovation and Socioeconomic Development
- Redox biology and oxidative stress
- FOXO transcription factor regulation
- Congenital heart defects research
- NF-κB Signaling Pathways
- Agricultural risk and resilience
- Phagocytosis and Immune Regulation
- Private Equity and Venture Capital
Boston Children's Hospital
2020-2025
Harvard University
2020-2024
Boston Children's Museum
2022-2023
Wayne State University
2018-2019
Kresge Eye Institute
2018
Indian Institute of Chemical Biology
2015-2017
University of Mumbai
2016
Epsin endocytic adaptor proteins are implicated in the progression of atherosclerosis; however, underlying molecular mechanisms have not yet been fully defined. In this study, we determined how epsins enhance endothelial-to-mesenchymal transition (EndoMT) atherosclerosis and assessed efficacy a therapeutic peptide preclinical model disease.
Diabetes mellitus can cause impaired and delayed wound healing, leading to lower extremity amputations; however, the mechanisms underlying regulation of vascular endothelial growth factor-dependent (VEGF-dependent) angiogenesis remain unclear. In our study, molecular underpinnings dysfunction in diabetes are investigated, focusing on roles disabled-2 (Dab2) Forkhead box M1 (FOXM1) VEGF receptor 2 (VEGFR2) signaling cell function. Bulk RNA-sequencing analysis identified significant...
Diabetes increases oxidative stress in the retina and dysfunctions their mitochondria, accelerating capillary cell apoptosis. A 66 kDa adaptor protein, p66Shc, is considered as a sensor of stress-induced In pathogenesis diabetic retinopathy, progressive disease, reactive oxygen species (ROS) production by activation small molecular weight G-protein (Ras-related C3 botulinum toxin substrate 1 [Rac1])-Nox2 signaling precedes mitochondrial damage. Rac1 facilitated guanine exchange factors...
Abstract The epsin family of endocytic adapter proteins are widely expressed, and interact with both lipids to regulate a variety cell functions. However, the role epsins in atherosclerosis is poorly understood. Here, we show that deletion endothelial reduces inflammation attenuates using culture mouse models this disease. In atherogenic cholesterol-treated murine aortic cells, ubiquitinated endoplasmic reticulum protein inositol 1,4,5-trisphosphate receptor type 1 (IP3R1), which triggers...
Estrogen receptor-negative (ER-negative) breast cancer is thought to be more malignant and devastating than ER-positive cancer. ER-negative exhibits elevated NF-κB activity, but how this abnormally high activity maintained poorly understood. The importance of linear ubiquitination, which generated by the ubiquitin chain assembly complex (LUBAC), increasingly appreciated in signaling, regulates cell activation death. Here, we showed that epsin proteins, a family ubiquitin-binding endocytic...
Backgrounds/Aims: The lipid induced insulin resistance is a major pathophysiologic mechanism underlying glucose intolerance of varying severity. PPARα-agonists are proven as effective hypolipidemic agents. aim this study was to see if impaired uptake in palmitate treated myotubes reversed by fenofibrate. Methods: Palmitate-treated were used model for resistance, uptake, fatty acid oxidation and ceramide synthesis. mRNA levels CPT1 CPT2 determined PCR array Q-PCR. Results: incubation with 750...
Our study emphasises the importance of dietary fat modification in modulating oxidative stress-induced glucose tolerance.
Background: The endothelial epsin 1 and 2 endocytic adaptor proteins play an important role in atherosclerosis by regulating the degradation of calcium release channel inositol 1,4,5-trisphosphate receptor type (IP3R1). In this study, we sought to identify additional targets responsible for epsin-mediated atherosclerotic cell activation inflammation vitro vivo. Methods: Atherosclerotic ApoE-/- mice with cell-specific deletion on a global knock-out background (EC-iDKO/ApoE-/-), aortic cells...
The present study conducted an analysis of the stock market integration India and a few selected countries globe. used Engle-Granger bivariate co-integration test for analytical purpose ascertaining long run equilibrium relation among countries. relationship with some across globe was analyzed over three different phases. It observed that cointegration other markets increasingly improving years financial liberalization. found Indian more responsive to Asian during recession phase than in any...
Abstract Diabetes mellitus can cause impaired and delayed wound healing, leading to lower extremity amputations; however, the mechanisms underlying regulation of vascular endothelial growth factor (VEGF)-dependent angiogenesis remain uncertain could reveal new therapeutic targets. In our study, molecular underpinnings dysfunction in diabetes were investigated, focusing on roles Disabled-2 (Dab2) Forkhead Box M1 (FoxM1) VEGF receptor 2 (VEGFR2) signaling cell (EC) function. Bulk...
<b>Abstract ID 87958</b> <b>Poster Board 264</b> CD45 is a marker of hematopoietic cells, which rarely expressed in endothelial cells (EC). However, recent studies indicated that indispensable driving the endothelial-to-mesenchymal transition (EndMT) following sheep myocardial infarction. EC activation hallmark initiation and atheroma progression; EndMT has also been implicated pathogenesis atherosclerosis. Here, we aim to investigate whether contributes progression atherosclerosis by...
The sub-prime crisis in US that had its origin 2007–08 devastating effect the financial segment of economics across major part world which subsequently transmitted to real economy thus causing prolonged recession. Banking sector was got affected during posed systemic risk. present study focused on how different commercial banks India performed as unfolded. objective see all ranked higher vis-à-vis their competitors terms maintaining a sound balance between profitability and stability crisis....
Background: The anti-phagocytic molecule CD47 is upregulated in atherosclerotic plaques of patients with cerebrovascular disease. However, the role endothelial cell-specific pathogenesis atherosclerosis has not yet been defined. Kojima et.al . described atheroprotective effect anti-CD47 antibody by enhancing efferocytosis atherosclerosis. In this study, we determined whether endothelialCD47 regulates Methods: Susceptibility to was evaluated cross sections aortic sinus mice. Using single-cell...
Background: Diabetes-related vascular complications underlie a number of life-threatening conditions including cardiovascular disease, stroke, and peripheral limb ulcerations, the latter which can lead to severe infections multitude serious medical issues. Vascular endothelial growth factor receptor 2 (VEGFR2) is critical regulator physiological pathological angiogenesis. Therefore, VEGFR2 signaling should be tightly controlled promote neovascularization when beneficial regeneration reduced,...
Abstract The forkhead box O1 (FOXO1) transcription factor plays critical roles in regulating not only metabolic activity but also angiogenesis the vascular endothelium 1–4 . Our previous studies show that epsin endocytic adaptors can regulate both and lymphangiogenesis 5–7 Endothelial cells (ECs) lining inside of blood vessels are continuously exposed to circulating insulin insulin-like growth factors (IGFs). Emerging evidences suggest ECs affect β-cell function 8–11 Excessive IGF2,...
Hypothesis: VSMC play crucial roles in atherosclerosis via phenotypic switching. The trans-differentiation of into other cell types might contribute to atherosclerotic lesion development, progression, and the subsequent diseases such as myocardial infarction or stroke. Epsins, a family endocytic adaptors, are for development progression; yet, role epsins modulation is unknown. Methods Results: To decipher regulating atheroma we created WT SMC-specific inducible epsin1/2 double knockout...