A5068264001- Mental Health and Psychiatry
- Psychiatric care and mental health services
- Schizophrenia research and treatment
- Psychosomatic Disorders and Their Treatments
- Body Image and Dysmorphia Studies
- Health and Medical Studies
- Race, Genetics, and Society
- Mental Health Treatment and Access
- Treatment of Major Depression
- Functional Brain Connectivity Studies
- Healthcare Decision-Making and Restraints
- Transcranial Magnetic Stimulation Studies
- Neurotransmitter Receptor Influence on Behavior
- Psychedelics and Drug Studies
- Bipolar Disorder and Treatment
- Forensic Toxicology and Drug Analysis
- Psychotherapy Techniques and Applications
- Mental Health and Patient Involvement
- Neuroscience and Neuropharmacology Research
- Neuroscience and Music Perception
- Posttraumatic Stress Disorder Research
- Primary Care and Health Outcomes
- Healthcare professionals’ stress and burnout
- Traumatic Brain Injury Research
- Mental Health Research Topics
King's College London
2016-2025
South London and Maudsley NHS Foundation Trust
2025
Brunel University of London
2024-2025
Imperial College London
2024-2025
National Health Service
2016-2025
West London Mental Health NHS Trust
2021-2024
University College London
2019-2024
Augusta University Health
2024
Home Office
2023
British Library
2023
Depression is a potentially life-threatening disorder affecting millions of people across the globe. It huge burden to both individual and society, costing over £9 billion in 2000 alone: World Health Organisation (WHO) cited it as third leading cause global disability 2004 (first developed world), project will be by 2030. The serendipitous discovery antidepressants has revolutionized our understanding management depression: however, their efficacy treatment depression long been debated...
Lithium has been used for the treatment of mood disorders over 60 years, yet exact mechanisms by which it exerts its therapeutic effects remain unclear. Two enzymatic chains or pathways emerge as targets lithium: inositol monophosphatase within phosphatidylinositol signalling pathway and protein kinase glycogen synthase 3. inhibits these enzymes through displacing normal cofactor magnesium, a vital regulator numerous pathways. Here we provide an overview evidence, supporting role inhibition...
Summary There is an urgent need to provide evidence-based well-being and mental health support for front-line clinical staff managing the COVID-19 pandemic who are at risk of moral injury illness. We describe evidence base a tiered model care, practical steps on its implementation.
Dysregulation of mesolimbic dopamine transmission is implicated in a number psychiatric illnesses characterised by disruption reward processing and goal-directed behaviour, including schizophrenia, drug addiction impulse control disorders associated with chronic use agonists. Amphetamine sensitization (AS) has been proposed to model the development this aberrant signalling subsequent dysregulation incentive motivational processes. However, humans effects AS on dopamine-sensitive neural...
Striatal cholinergic dysfunction may be important in Huntington disease (HD). We studied whether donepezil improves chorea, cognition, and quality of life (QoL) HD. Thirty patients were randomly assigned to treatment with or placebo. At the doses studied, did not improve QoL. Adverse events similar between both groups. Based on this small sample study, was an effective for
#### What you need to know Identifying and managing acute drug related harms problematic substance misuse cuts across medical specialties. Data suggest that clinicians are seeking readily accessible information on novel psychoactive substances (NPS), incorrectly known as “legal highs.” Clinicians may encounter acutely disturbed or unwell patients, individuals with harm dependency chronic NPS use, those reporting incidental consumption might require psychoeducation monitoring. Such...