A5103102691- Aortic aneurysm repair treatments
- Vascular Procedures and Complications
- Peripheral Artery Disease Management
- Venous Thromboembolism Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Protease and Inhibitor Mechanisms
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Renal and Vascular Pathologies
- Infectious Aortic and Vascular Conditions
- RNA Interference and Gene Delivery
- Cardiac, Anesthesia and Surgical Outcomes
- Organ Transplantation Techniques and Outcomes
- Estrogen and related hormone effects
- Antiplatelet Therapy and Cardiovascular Diseases
- Organ Donation and Transplantation
- Lysosomal Storage Disorders Research
- Cell Adhesion Molecules Research
- Hormonal and reproductive studies
- Tracheal and airway disorders
- Cerebrovascular and Carotid Artery Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Diagnosis and Treatment of Venous Diseases
- Menopause: Health Impacts and Treatments
Amicus Therapeutics (United States)
2022-2025
University of Tennessee at Knoxville
2012-2024
Indiana University School of Medicine
2022
Indiana University – Purdue University Indianapolis
2022
Amicus Therapeutics (United Kingdom)
2022
Hospital de Niños Superiora Sor María Ludovica
2018
University of Tennessee Medical Center
2004-2017
Creative Research Enterprises (United States)
2015
Naval Medical Research Command
1976-2015
University School
2015
Abstract PROPEL (ATB200-03; NCT03729362) compared the efficacy and safety of cipaglucosidase alfa plus miglustat (cipa + mig), a two-component therapy for late-onset Pompe disease (LOPD), versus alglucosidase placebo (alg pbo). The primary endpoint was change in 6-min walk distance (6MWD) from baseline to week 52. During PROPEL, COVID-19 interrupted some planned study visits assessment windows, leading delayed visits, make-up assessments patients who missed ≥ 3 successive infusions before at...
BRENNAN, MURRAY F. M.D.; GOLDMAN, MITCHELL H. O'CONNELL, RUARY C. KUNDSIN, RUTH B. D.Sc.; MOORE, FRANCIS D. M.D. Author Information
The kidney to aortic blood flow index (K/A ratio) is the ratio of slopes upstrokes renal and histograms, derived from regions interest applied sequential gamma camera images first transit a 99mTc bolus. This proved in our previous dog studies have good correlation with artery flow. In 190 clinical allografts reported here, K/A ratios correlate well independently established retrospective clinical-pathologic assessment functional status. Normal range for was 50 patients no demonstrable...
Seventy fresh frozen biopsies of 22 human heart allografts were stained with mouse antihuman monoclonal antibodies (OKT-4, OKT-8, and OKM-1) using the immunoperoxidase method. The numbers infiltrating cell phenotypes correlated patients' clinical status histopathological diagnoses biopsies. At clinically stable stage number OKT-4-positive cells (T-4 cells, helper/inducer), OKT-8-positive (T-8 suppressor/cytotoxic), OKM-1-positive (M-1 monocyte/macrophage) T4/T8 ratio lowest. During early...
Diabetes is known to increase poly-ADP-ribose-polymerase (PARP) activity and posttranslational poly-ADP-ribosylation of several regulatory proteins involved in inflammation energy metabolism. These experiments test the hypothesis that PARP inhibition will modulate hind limb ischemia reperfusion (IR) a mouse model type-II diabetes ameliorate ribosylation activity/transnuclear localization key glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH).db/db mice underwent 1.5 hours...