A5001715820- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Lymphoma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Neuroendocrine Tumor Research Advances
- Glioma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Neurofibromatosis and Schwannoma Cases
- Nanoplatforms for cancer theranostics
- Cancer and Skin Lesions
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Nonmelanoma Skin Cancer Studies
- Ear and Head Tumors
- Wnt/β-catenin signaling in development and cancer
- Neuroblastoma Research and Treatments
- Metastasis and carcinoma case studies
- Colorectal Cancer Surgical Treatments
- Cellular Mechanics and Interactions
- Colorectal and Anal Carcinomas
- Occupational and environmental lung diseases
National Cheng Kung University Hospital
2010-2024
National Cheng Kung University
2022
Chi Mei Medical Center
2006
Alcohol consumption is an established risk factor for head and neck cancer (HNC). The major carcinogen from alcohol acetaldehyde, which may be produced by humans or oral microorganisms through the metabolism of ethanol. To account different sources acetaldehyde production, current study examined interplay between consumption, hygiene (as a proxy measure growth microorganisms), alcohol-metabolizing genes (ADH1B ALDH2) in HNC. We found that both fast (*2/*2) slow (*1/*1+ *1/*2) ADH1B genotypes...
Background The literature regarding esophageal fistula after definitive concurrent chemotherapy and intensity modulated radiotherapy (IMRT) for squamous cell carcinoma (ESCC) remains lacking. We aimed to investigate the risk factors of among ESCC patients undergoing chemoradiotherapy (CCRT) via IMRT technique. Methods A total 129 consecutive receiving CCRT with between 2008 2018 were reviewed. cumulative incidence survival estimated by Kaplan–Meier method compared groups log-rank test....
Pancreatic cancer is among the leading causes of cancer-related death and remains a formidable therapeutic challenge. To date, surgical resection chemotherapy have been standards care. Methotrexate (MTX), which recognized as refractory drug for pancreatic cells, was conjugated to surface LiYF4:Ce3+ nanoparticles (NP-MTX) through photocleavable linker molecule. When NPs are stimulated by X-rays, they emit light, induces photocleavage photolabile molecule release MTX. MTX can target tumors,...
Abstract Background The literature regarding pericardial effusion after definitive concurrent chemotherapy and intensity modulated radiotherapy (IMRT) for esophageal cancer was lacking. This study aimed to investigate the risk factors of in patients undergoing IMRT. Methods A total 126 consecutive treated with IMRT between 2008 2018 were reviewed. determined on computed tomography scan chest graded by Common Terminology Criteria Adverse Events, version 4.0. cumulative incidence estimated...
In this study, we aimed to analyze whether serum prealbumin and transferrin have a higher sensitivity than albumin for detecting malnutrition predicting survival in esophageal cancer patients. A total of 212 patients were prospectively enrolled. Serum albumin, prealbumin, analyzed by enzyme-linked immunosorbent assays. The association nutritional markers with was analyzed. We found that presented 44.5% the patients, while 56.6% unaware their body weight change. area under curve diagnosing...
Abstract Leptomeningeal metastasis (LM) occurs when tumor cells spread to the leptomeningeal space surrounding brain and spinal cord, thereby causing poor clinical outcomes. The triple-negative breast cancer (TNBC) has been associated with symptoms of LM mechanism remained unclear. Through proteomic analysis, we identified high expression ICAM2 in metastatic TNBC cells, which promoted colonization cord resulted survival vivo. Two-way demonstration indicated that levels blood–cerebrospinal...
We assessed the feasibility of combined endoscopic ultrasound and computed tomography on response evaluation in patients with esophageal squamous cell carcinoma treated by definitive chemoradiotherapy, impact prognosis.Sixty chemoradiotherapy were followed miniprobe tomography. The post-treatment wall thickness was measured ultrasound. Metastatic tumors evaluated correlation between image findings prognosis evaluated.Twenty-four (40%) had stricture after which limited complete endoscopy....
Mammalian STE20-like kinase 1 (MST1/STK4/KRS2) encodes a serine/threonine that is the mammalian homolog of Drosophila Hippo. STK4 plays an important role in controlling cell growth, apoptosis, and organ size. has been studied many cancers with previous studies indicating involvement colon cancer lymph node metastasis highlighting its potential as diagnostic marker for cancer. However, defect promoting progression still understudied. Here, we found was significantly downregulated associated...
Although substantial evidence supports a 20–30% risk reduction of colon cancer, breast and endometrial cancer by physical activity (PA), the for head neck (HNC) is limited. Three published studies on association between PA HNC have generated inconsistent results. The current study examined recreational (RPA) with more detailed assessment intensity, frequency, duration, total years RPA. Data RPA were collected from 623 cases 731 controls in-person interview using standardized questionnaire....
Abstract Currently, the survival rate for breast cancer is more than 90%, but once cells metastasize to distal organs, dramatically reduced, less 30%. Triple-negative accounts 15-20% of all cancers. (TNBC) associated with poor prognostic and diagnostic outcomes due limiting therapeutic strategies, relative non-TNBC Therefore, development targeted therapy TNBC metastasis remains an urgent issue. In this study, high Carboxyl-terminal modulator protein (CTMP) significantly recurrence...
Using endoscopy as the reference, this study evaluated accuracy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in measuring distance from incisors to PET detectable esophageal cancer. If there is high concordance between endoscopic and measurements, our results may provide a basis use FDG PET/CT cooperation with measurement localize those CT undetectable tumors for radiotherapy planning.
Esophageal squamous cell carcinoma (ESCC) is a common and fatal malignancy with an increasing incidence worldwide. Over the past decade, concurrent chemoradiotherapy (CCRT) or without surgery emerging therapeutic approach for locally advanced ESCC. Unfortunately, many patients exhibit poor response develop acquired resistance to CCRT. Once occurs, overall survival rate drops down rapidly proper further treatment options, poses critical clinical challenge ESCC therapy. Here, we utilized...
Large primary tumor volume has been identified as a poor prognostic factor of esophageal squamous cell carcinoma (ESCC) treated with definitive concurrent chemoradiotherapy (CCRT). However, when neoadjuvant CCRT and surgery are adopted, the impact lymph node (LN) on clinical outcomes in ESCC remains to be elucidated. This study included 107 patients who received for ESCC. The LN was measured using radiotherapy planning computed tomography scans, correlated overall survival (OS), disease-free...
1099 Background: De novo and acquired resistance to trastuzumab-based therapy is an active area of research. One the mechanisms expression p95HER2 which clinically associated with aggressive disease, poor prognosis, lack response trastuzumab. Clinical studies on are limited due highly sensitive specific assays accurately measure its activation. Methods: A novel technology capable specifically detecting phosphorylation receptor tyrosine kinases (RTKs) (Prometheus proprietary COPIA assay) was...
Abstract Background: The prognostic significance of cardiac radiation dose in esophageal cancer after definitive concurrent chemoradiotherapy (CCRT) remains largely unknown. We aimed to investigate the association between dose-volume parameters and overall survival (OS) squamous cell carcinoma (ESCC) CCRT. Methods: One hundred twenty-one ESCC patients undergoing CCRT with intensity modulated radiotherapy technique 2008 2018 were reviewed. Cardiac calculated. Survival cumulative incidence...
Malignant tumors arising in the paranasal sinuses account for 0.2 to 0.8% of all cancers. Squamous cell carcinoma is by far most common malignant tumor. Primary small neuroendocrine ethmoid sinus an uncommon and distinctive tumor with aggressive clinical behavior. Besides, its morphological immuno-histo-chemical features are similar those lung. The need a multi-disciplinary treatment approach combining surgery or radiotherapy chemotherapy indicated treating these tumors. We report case...
Purpose: To analyze the treatment outcomes of radiation therapy (RT) in breast cancer patients who developed locoregional recurrence (LRR) after initial with mastectomy, and to investigate prognostic factors influencing survival. Materials Methods: We retrospectively reviewed medical records received RT for post-mastectomy LRR our hospital from 1989 2009. Patients had previous distant metastasis before were excluded, but synchronous included this study. Clinicopathologic parameters analyzed....
Background: Matrix metalloproteinases (MMPs) play important roles in tumor development and progression. We tested whether the serum levels of MMP-3, 7 9 can serve as biomarkers to screen for esophageal squamous cell carcinoma (ESCC) or evaluate its treatment response.Methods: Serum were measured 63 ESCC patients 30 healthy controls by enzyme-linked immunosorbent assay correlated with clinicopathological parameters. Patients who received neoadjuvant concurrent chemoradiation therapy (CCRT)...
Purpose: To analyze the treatment outcome of patients with limited-stage small cell carcinoma (SmCC) esophagus.Methods: Patients SmCC esophagus presenting to Taipei Veterans General Hospital between 1985 and 2001 were retrospectively reviewed. Demographic clinical data presented analyzed. We calculated overall survival Kaplan-Meier method compared different groups log-rank test.Results: represented 0.89% esophageal malignancies in this institution. Eleven (one female ten male) included...
Background: Trichoepithelioma is a rare skin tumor that arises from hair follicles. The most common locations are in the scalp, forehead, nose and upper lip can cause significant cosmetic functional impairment. In this study, we report case of multiple trichoepitheliomas treated by radiation therapy which demonstrated dramatic response with improvement. Case: A 57-year-old woman suffered coalesced lesions her bilateral eyebrows for three years. She had received numerous treatments including...