A5047527760- Tropical and Extratropical Cyclones Research
- Meteorological Phenomena and Simulations
- Climate variability and models
- Tendon Structure and Treatment
- Ocean Waves and Remote Sensing
- Veterinary Equine Medical Research
- Shoulder Injury and Treatment
- Wind and Air Flow Studies
- Oceanographic and Atmospheric Processes
- Orthopedic Surgery and Rehabilitation
- Solar and Space Plasma Dynamics
- Mesenchymal stem cell research
- Fluid Dynamics and Turbulent Flows
- Sports injuries and prevention
- Tissue Engineering and Regenerative Medicine
- Geophysics and Gravity Measurements
- Veterinary Pharmacology and Anesthesia
- Wound Healing and Treatments
- Osteoarthritis Treatment and Mechanisms
- Veterinary Orthopedics and Neurology
- Coastal and Marine Dynamics
- Pluripotent Stem Cells Research
- Musculoskeletal synovial abnormalities and treatments
- Fluid Dynamics and Vibration Analysis
- Geological formations and processes
Ludwig-Maximilians-Universität München
2015-2025
Royal Veterinary College
2015-2024
University of Lincoln
2024
University College London
2008-2024
University of London
2007-2023
Gold Skin Care Center
2006-2018
Argonne National Laboratory
2011-2017
Texas A&M University
2015-2017
Naval Postgraduate School
2016
Imperial College London
2010
Gene-for-gene disease resistance typically includes a programmed cell death response known as the hypersensitive (HR). The Arabidopsis thaliana dnd1 mutant was previously isolated line that failed to produce HR in avirulent Pseudomonas syringae pathogens; plants homozygous for recessive - 1 mutation still carry out effective gene-for-gene resistance. also causes constitutive systemic and elevated levels of salicylic acid. In present study, positional cloning approach used isolate DND1. DND1...
A significant number of tropical cyclones move into the midlatitudes and transform extratropical cyclones. This process is generally referred to as transition (ET). During ET a cyclone frequently produces intense rainfall strong winds has increased forward motion, so that such systems pose serious threat land maritime activities. Changes in structure system it evolves from an during necessitate changes forecast strategies. In this paper brief climatology given challenges associated with...
Abstract We present numerical experiments to investigate axisymmetric interpretations of tropical cyclone spin‐up in a three‐dimensional model. Two mechanisms are identified for the mean tangential circulation. The first involves convergence absolute angular momentum above boundary layer and is mechanism spin up outer circulation, i.e. increase vortex size. second within inner core. It associated with development supergradient wind speeds layer. existence these two provides plausible...
We review the four main paradigms of tropical cyclone intensification that have emerged over past five decades, discussing relationship between them and highlighting their strengths weaknesses.A major focus is on a new paradigm articulated in series recent papers using observations highresolution, three-dimensional, numerical model simulations.Unlike three previous paradigms, all which assumed axial symmetry, one recognises presence localised, buoyant, rotating deep convection grows...
Abstract We present numerical‐model experiments to investigate the dynamics of tropical‐cyclone amplification and its predictability in three dimensions. For prototype problem beginning with a weak‐tropical‐storm‐strength vortex, emergent flow becomes highly asymmetric dominated by deep convective vortex structures, even though as posed is essentially axisymmetric. The asymmetries that develop are sensitive boundary‐layer moisture distribution. When small random perturbation added boundary...
A previous mutant screen identified Arabidopsis dnd1 and dnd2 “defense, no death” mutants, which exhibit loss of hypersensitive response (HR) cell death without gene-for-gene resistance. The phenotype is caused by mutation the gene encoding cyclic nucleotide-gated (CNG) ion channel AtCNGC2. This study characterizes plants. Even in presence high titers Pseudomonas syringae expressing avrRpt2, most leaf mesophyll cells exhibited HR. These plants retained strong RPS2-, RPM1-, or RPS4-mediated...
Optimal management of tendon overuse injuries in equine and human athletes should avoid the formation excessive scar tissue, regenerate normal matrix, reduce re-injury rates. We hypothesized that implantation marrow-derived stromal stem cells (BM-MSCs), far greater numbers than are present normally within would synthesize a matrix more closely resembling hence increase capacity to return performance successfully. This article reviews technique used clinically horse current outcome data for...
Intra-articular injection of mesenchymal stem cells (MSCs) is efficacious in osteoarthritis therapy. A direct comparison the response synovial joint to intra-articular autologous versus allogeneic MSCs has not been performed. The objective this study was assess clinical repeated prepared a way minimize xeno-contaminants large animal model.Intra-articular injections bone marrow-derived, culture-expanded forelimb metacarpophalangeal were performed at week 0 and 4 (six autologous; six with...
Objectives: Sequence variation within the COL5A1 and TNC genes are known to associate with Achilles tendinopathy. The primary aim of this case-control genetic association study was investigate whether variants matrix metalloproteinase 3 ( MMP3 ) gene also contributed both tendinopathy tendon rupture in a Caucasian population. A secondary establish interacted rs12722 variant raise risk these pathologies. Methods: 114 subjects symptoms pathology 98 healthy controls were genotyped for rs679620,...
The principal hypotheses of a new model tropical cyclogenesis, known as the marsupial paradigm, were tested in context Atlantic disturbances during National Science Foundation (NSF)-sponsored Pre-Depression Investigation Cloud Systems Tropics (PREDICT) experiment 2010. PREDICT was part tri-agency collaboration, along with Aeronautics and Space Administration's Genesis Rapid Intensification Processes (NASA GRIP) Oceanic Atmospheric Intensity Forecasting Experiment (NOAA IFEX), intended to...
Abstract We investigate the extent to which azimuthally–averaged fields from a three‐dimensional, non‐hydrostatic, tropical cyclone model can be captured by axisymmetric balance theory. The secondary (overturning) circulation and balanced tendency for primary are obtained solving general form of Sawyer–Eliassen equation with diabatic heating, eddy heat fluxes tangential momentum sources (eddy fluxes, boundary‐layer friction subgrid‐scale diffusion) diagnosed model. occurrence regions weak...
This paper presents the results of a field expedition mounted in late September/early October 1979 to investigate structure and origin “morning glory” Gulf Carpentaria northern Australia. The morning glory is line wind squall, accompanied by pressure jump, often long roll-cloud or series such clouds. It frequently occurs early morning, especially October, area. A light aircraft, fitted with temperature humidity probe, was flown two glories determine their thermodynamic structure, fields wore...
This article reviews progress in understanding the fluid dynamics and moist thermodynamics of tropical cyclone vortices. The focus is on vortex intensification structure. We discuss previous ideas many facets subject articulate also some open questions. advances reviewed herein provide new insight tools for interpreting complex vortex-convective phenomenology simulated observed cyclones.
Abstract. We present the results of idealized numerical experiments to examine difference between tropical cyclone evolution in three-dimensional (3-D) and axisymmetric (AX) model configurations. focus on prototype problem for intensification, which considers an initially unsaturated AX vortex gradient-wind balance f plane. Consistent with findings previous work, mature intensity 3-D is reduced relative that model. In contrast interpretations invoking barotropic instability related...
Abstract We present a critique of Emanuel's steady‐state hurricane model, which is precursor to his theory for potential intensity (PI). show that major deficiency the tacit assumption gradient wind balance in boundary layer, layer owes its existence imbalance radial momentum equation. If more complete boundary‐layer formulation included using profiles obtained from theory, tangential speed becomes supergradient, invalidating balance. degree supergradient depends on assumed depth. The full...
While fractures and tendon injuries are known to be important diseases in National Hunt (NH) racehorses during racing, there no accurate estimates of their incidence NH training yards.To estimate the suspensory ligament (TLIs) training; describe incurred compare injury rates by horse age, trainer, gender background (ex-flat vs. ex-store horses).Cohort data were collected from 14 UK yards for 2 racing seasons. Daily exercise regimens details TLIs occurring study horses recorded.Data gathered...
Summary Age‐associated and degenerative loss of functional integrity in soft tissues develops from effects cumulative subtle changes their extracellular matrix (ECM). The highly ordered tendon ECM provides the tissue with its tensile strength during loading. As age exercise collude high incidence tendinopathies, we hypothesized that aged tendons fail due to damage resulting a combination diminished repair fragmentation proteins induced by prolonged cyclical loading, this is an active...
We present idealized numerical model experiments to investigate the dependence of tropical-cyclone intensification and, in particular, kinematic structure boundary layer on boundary-layer parametrization model. The study is motivated by recent findings highlighting important dynamical role intensification. calculations are carried out using Pennsylvania State University– National Center for Atmospheric Research fifth-generation mesoscale (MM5). Predictions one five available schemes...
This paper presents a review of theoretical and observational studies relating to the low-level structure cold fronts explores factors that are pertinent frontal motion. Observational have shown that, in some cases, surface move at speeds faster than normal component wind all levels lower troposphere therefore propagate. Other case flow immediately behind front it is has local gravity current, its speed movement being well determined by current equation. Them different types behavior related...