A5102949078- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthetic Organic Chemistry Methods
- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Catalytic Alkyne Reactions
- Microbial Natural Products and Biosynthesis
- Cyclopropane Reaction Mechanisms
- Synthesis of Indole Derivatives
- Carbohydrate Chemistry and Synthesis
- Organophosphorus compounds synthesis
- Crystallography and molecular interactions
- Chemical synthesis and alkaloids
- Phosphorus compounds and reactions
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Glycosylation and Glycoproteins Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Bioactive Compounds and Antitumor Agents
- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Reactions
- Plant-based Medicinal Research
- Microwave-Assisted Synthesis and Applications
- Catalytic Cross-Coupling Reactions
Max-Planck-Institut für Kohlenforschung
2018
Institut de Chimie des Substances Naturelles
2013-2016
Université Paris-Sud
2012-2015
Centre National de la Recherche Scientifique
2012-2015
Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique
2013
Institut de Chimie Moléculaire et des Matériaux d'Orsay
2012
Laboratoire de Synthèse Organique
2012
We developed a simple and convenient method to assemble biaryls exploiting photoredox catalyst visible light.
α-Amino allenephosphonates were easily prepared in two steps from protected amines, propargyl alcohols, and chlorophosphites. First, ynamides synthesized unprotected 1-bromopropargyl alcohols using a copper(II) catalyzed coupling reaction. In the second step, previously transformed directly to allenes through [2,3]-sigmatropic rearrangement of phosphites. This efficient method led formation series α-amino with diverse substituents on amine, phosphonate, allene moieties.
Abstract α‐Amino vinylphosphonates were prepared by chemo‐ and stereoselective reduction of α‐amino allenephosphonates. Our results showed that the substituents on allene, phosphonate, nitrogen moieties affected stereoselectivity reduction. Z ‐α‐Amino with good selectivities up to > 95:5.
A conceptually novel reaction cascade is presented, which allows readily available enynes to be converted into functionalized 1,3-dienes comprising a stereodefined tetrasubstituted alkene unit; such compounds are difficult make by conventional means. The overall transformation thought commence with formation of metallacyclic intermediate that evolves via cleavage an unstrained C-X bond in its backbone. This non-canonical cycloisomerization process followed cross-coupling step, reductive C-C...
A methodological study towards the total synthesis of marmycin A/B is described exploiting a commercial anthraquinone molecule as model compound. The challenging synthetic pathway uncovers copper-catalysed Ullmann cross-coupling to attach sugar backbone by means C–N bond formation and, finally, an intramolecular Friedel–Crafts C–C glycosylation successfully afford core structure A. This methodology has been applied genuine moiety leading natural product and simpler structural analogues.
A straightforward total synthesis of a small panel natural benzo[c]phenanthridines is described. The selective coupling an aryl triflate with bromobenzylamine by means palladium/norbornene joint catalysis and sequential transfer hydrogenation deliver these alkaloids in one pot. Dihydrophenanthridines initially formed undergo dehydrogenation smoothly while norbornene acts both as catalyst for their assembly sacrificial olefin dehydrogenation. Palladium powerful tool organic chemistry found...
Abstract Blue LED‐induced reaction between aryldiazonium salts and arenes to biaryls proceeds with some interesting regioselective features depending on the substitution patterns of both partners as well use additives (e.g., K 2 CO 3 ).
Abstract A new protocol for the synthesis of a variety title compounds is presented with good to excellent stereoselectivity towards (Z)‐conformation.
Abstract A straightforward method to prepare various α‐amino allenephosphonates is reported.