A5012341281- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Tryptophan and brain disorders
- Biosimilars and Bioanalytical Methods
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Pharmaceutical studies and practices
- Neurotransmitter Receptor Influence on Behavior
- Cancer therapeutics and mechanisms
- Helicobacter pylori-related gastroenterology studies
- Galectins and Cancer Biology
- Advanced Drug Delivery Systems
- Metabolism and Genetic Disorders
- SARS-CoV-2 detection and testing
- Pharmacological Receptor Mechanisms and Effects
- Maternal Mental Health During Pregnancy and Postpartum
- Chemical Reaction Mechanisms
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Cancer Treatment and Pharmacology
- 3D Printing in Biomedical Research
- Drug Solubulity and Delivery Systems
- Analytical Methods in Pharmaceuticals
Gilead Sciences (United States)
2023-2024
Simulations Plus (United States)
2019
University of Florida
2016-2017
Massachusetts College of Pharmacy and Health Sciences
2014-2017
Biogen (United States)
2015-2016
Dr. Reddy's Laboratories (United States)
2008-2011
Deccan College of Medical Sciences
2008
Dr. Reddy's Laboratories (India)
2007
There is an unmet need for safe and efficacious oral therapies COVID-19 with low potential drug-drug interactions. Obeldesivir orally administered nucleoside prodrug that has shown antiviral potency in nonclinical studies against SARS-CoV-2 its circulating variants. metabolized to the active triphosphate (GS-443902), which acts as inhibitor of RNA-dependent RNA polymerase, thereby inhibiting viral synthesis. Here, we report safety, tolerability, pharmacokinetics from a first-in-human,...
Editorial
Opinion
Background H. pylori causes gastritis and peptic ulcers is a risk factor for the development of gastric carcinoma. Many proteins such as urease, porins, flagellins toxins lipo-polysaccharides have been identified potential virulence factors which induce proinflammatory reaction. We report immunogenic potentials isocitrate dehydrogenase (ICD), an important house keeping protein pylori. Methodology/Principal Findings Amino acid sequences ICD were subjected to in silico analysis regions with...
Tolmetin (TMT, CAS 26171-23-3) is a non-steroidal anti-inflammatory drug (NSAID) indicated for the relief of signs and symptoms osteoarthritis, rheumatoid arthritis juvenile arthritis. As TMT causes gastro-intestinal side effects like other NSAIDs, its non-acidic prodrug amtolmetin guacil (AMG, 87344-06-7) was synthesized. AMG has similar NSAID properties with additional gastroprotective property. The aim this study to investigate whether are differentially metabolised in rat human plasma...
<p class="ADMETabstracttext">Cytochrome P-450 (CYP) are the most common drug metabolizing enzymes and abundantly expressed in liver apart from kidney, lungs, intestine, brain etc. Their expression levels change with physiological conditions disease states. The of these CYPs is less human foetus neonates compared to adults, which results lower clearance xenobiotics infants adults. Hepatocytes cells largely used study CYPs. We have isolated hepatocytes aborted metabolism six probe...
Editorial for special issue of the journal
Abstract The discovery of small‐molecule novel chemical entities (NCEs) is often a complex play between appropriate structural requirements and optimization the desired efficacy, safety pharmacokinetic properties. One typical variants such as having an active carbon–carbon double bond ( α , β ‐unsaturated carbonyl group) in xenobiotics may lead to stability issues. Such functionalities are extremely reactive, paving way nucleophilic attack by endogenously occurring ubiquitous nucleophiles...