A5067968401- Diverse Scientific Research Studies
- CAR-T cell therapy research
- Vehicle emissions and performance
- Air Quality and Health Impacts
- Air Quality Monitoring and Forecasting
- Retinoids in leukemia and cellular processes
- Nanowire Synthesis and Applications
- Cardiac Ischemia and Reperfusion
- Signaling Pathways in Disease
- Reproductive Physiology in Livestock
- Animal health and immunology
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
- Urban Transport and Accessibility
- Livestock Management and Performance Improvement
- Transportation Planning and Optimization
- Veterinary medicine and infectious diseases
- Chemokine receptors and signaling
- Reproductive Biology and Fertility
- Retinopathy of Prematurity Studies
- Ginger and Zingiberaceae research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Contact Dermatitis and Allergies
- Family Caregiving in Mental Illness
Chandigarh University
2025
All India Institute of Medical Sciences Bhopal
2025
Takeda (United States)
2022-2024
Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
2024
Nanaji Deshmukh Veterinary Science University
2024
Indian Institute of Technology Roorkee
2022-2024
Institute of Technology Management
2023
Desh Bhagat Ayurvedic College and Hospital
2022
Ayurvedic Institute
2020
Institute of Chartered Financial Analysts of India
2020
Abstract T cells expressing CD19-targeting chimeric antigen receptors (CARs) reveal high efficacy in the treatment of B cell malignancies. Here, we report that receptor fusion constructs (TRuCs) comprising an antibody-based binding domain fused to (TCR) subunits can effectively reprogram intact TCR complex recognize tumor surface antigens. Unlike CARs, TRuCs become a functional component complex. TRuC-T kill as potently second-generation CAR-T cells, but at significant lower cytokine release...
This study was designed to determine the effect of all-trans retinoic acid (RA) on development cardiac remodeling in a pressure overload rat model. Male Sprague-Dawley rats were subjected sham operation and aortic constriction procedure. A subgroup control constricted treated with RA for 5 mo after surgery. Pressure-overloaded showed significantly increased interstitial perivascular fibrosis, heart weight-to-body weight ratio, gene expression atrial natriuretic peptide brain peptide....
Cancer progression and metastasis involves interactions between tumor cells the microenvironment (TME). We reported that mice deficient for cytosolic phospholipase A(2) (cPLA(2)-KO) are protected against development of lung tumors. The goal this study was to examine role cPLA(2) in TME. Mouse cancer (CMT167 Lewis carcinoma cells) injected directly into lungs syngeneic formed a primary tumor, then metastasized other lobes mediastinal lymph nodes. Identical cPLA(2)-KO showed dramatic decrease...
Abstract Cardiomyocyte apoptosis has an important role in the transition from compensatory cardiac remodeling to heart failure. All‐trans retinoic acid (RA), a bioactive vitamin A derivative, prevents stretch‐ and angiotensin II (Ang II)‐induced hypertrophy. However, anti‐apoptotic potential of RA remains unexplored. Here, we demonstrate that Ang II‐induced is prevented by neonatal cardiomyocytes. improved mitochondrial function inhibiting reduction membrane potential, cytochrome c release...
Abstract Diabetes mellitus (DM) is a primary risk factor for cardiovascular diseases and heart failure. Activation of the retinoic acid receptor (RAR) retinoid X (RXR) has an anti‐diabetic effect; but, role in diabetic cardiomyopathy remains unclear. Using neonatal adult cardiomyocytes, we determined RAR RXR hyperglycemia‐induced apoptosis expression renin‐angiotensin system (RAS) components. Decreased nuclear RARα RXRα, activation apoptotic signaling cell was observed high glucose (HG)...
The area of computer vision-based civil infrastructure defect identification is developing due to the ever-increasing efficiency hardware, image processing methodologies and sensor technologies. Finding crack damage in buildings essential guaranteeing both safety structural integrity. This study offers a novel method for identifying evaluating fractures by using artificial intelligence (AI) images. suggested approach makes use cutting-edge AI algorithms that can accurately analyze enormous...
Rapid detection of infectious diseases like COVID-19, flu, and dengue is crucial for healthcare professionals preparing contagious outbreaks. Given the constant mutations in viruses recurring emergence threats Nipah Zika, there an urgent demand a technology capable distinguishing between infections that share similar symptoms. In this paper, we utilize laser-based Raman scattered signals from drop dried blood plasma, combined with generative artificial intelligence, to provide rapid precise...
Work from our laboratory and others has demonstrated that activation of the nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) inhibits transformed growth non-small cell lung cancer (NSCLC) lines in vitro vivo. We have PPARγ promotes epithelial differentiation NSCLC by increasing expression E-cadherin, as well inhibiting COX-2 factor-κB. The Snail family transcription factors, which includes (Snail1), Slug (Snail2), ZEB1, is an important regulator epithelial-mesenchymal...
With increasing air pollution and its harmful effect on the residents of developing countries, prediction analysis pollutants have become an important research aspect. This study focuses spatiotemporal hourly particulate matter with different deep-learning modeling techniques for Delhi, India. The secondary data concentrations meteorological parameters four static monitors in area are collected from Central Pollution Control Board (CPCB) dates between January 2019 April 2021. South Delhi is...
The inability to obtain sufficient numbers of transduced cells remains a limitation in gene therapy. One strategy address this is vivo pharmacologic selection cells. We have previously shown that knockdown HPRT using lentiviral delivered shRNA facilitates efficient murine hematopoietic progenitor (HPC) 6-thioguanine (6TG). Herein, we now extend these studies human HPC. tested multiple constructs derived cell lines and identified the optimal sequence for 6TG resistance. then vector umbilical...
Tracheostomy is the common procedure for multiple medical indications and nurses must provide safe competent care to tracheostomy patients prevent complications. This study aimed assess knowledge skills on among staff working in selected hospitals of district Mohali, Punjab. A quantitative research approach with descriptive design was adopted. 100 were using convenient sampling technique (non probability sampling). Knowledge assessed structured questionnaire checklist care. The collected...
A growing number of patients with chronic kidney disease (CKD) are receiving home-based care and require support from non-professional healthcare providers, often family members, to manage CKD. Although dialysis is a demanding treatment, which requires considerable personal discipline care, there an important role caregiver for including assistance in daily activities, medication, fluid control, skin help cope stress. The aim the study was assess knowledge regarding post home among...