A5043652848- Vitamin D Research Studies
- Ovarian function and disorders
- Cervical Cancer and HPV Research
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Inflammatory mediators and NSAID effects
- Cancer-related molecular mechanisms research
- Systemic Lupus Erythematosus Research
- Health and Medical Research Impacts
- Lipoproteins and Cardiovascular Health
- Health disparities and outcomes
- Economic and Financial Impacts of Cancer
- Health Promotion and Cardiovascular Prevention
- Salivary Gland Tumors Diagnosis and Treatment
- Optimism, Hope, and Well-being
- Acute Ischemic Stroke Management
- Hospital Admissions and Outcomes
- Biological and pharmacological studies of plants
- Medicinal Plant Extracts Effects
- Bariatric Surgery and Outcomes
- Gestational Diabetes Research and Management
- Neuroendocrine regulation and behavior
- Artificial Intelligence in Healthcare and Education
- Drug-Induced Ocular Toxicity
- Zebrafish Biomedical Research Applications
University of Puerto Rico System
2018-2025
University of Puerto Rico, Medical Sciences Campus
2015-2024
Clinical Research Puerto Rico
2015-2020
National Institute on Minority Health and Health Disparities
2016
Mohs micrographic surgery (MMS) with melanoma antigen recognized by T-cell (MART-1) immunostaining is an effective treatment of cutaneous melanoma.To determine the efficacy MMS MART-1 immunostain in management invasive and situ melanoma.A retrospective cohort study evaluated 2,114 melanomas 1,982 patients excised using immunostain. The margins required for excision were calculated based on Breslow thickness, location, size. Survival local recurrence rates compared those historical...
Women living with HIV (WLWH) are at increased risk of persistent HPV infection and HPV-related cancers than persons without HIV. We aimed to describe the utilization primary secondary prevention strategies for among women by status in Puerto Rico (PR). performed a data analysis aged 21+ years (n = 469) evaluated Anal Neoplasia Clinic (ANC) University Comprehensive Cancer Center between 2014 2023. The outcomes were history vaccination, anal Pap screening, cervical screening past 3 years....
Abstract Background: Patient navigation (PN) services in cancer care have significantly benefited patients by reducing disparities outcomes, screening, and treatment. Identifying the characteristics of who need PN they may assist design targeted future programs. Therefore, our study aims to identify that are most needed this population determine association between for among Puerto Rico sociodemographic health-related factors. Methods: Our ongoing pilot cross-sectional study, START-PR, has...
Ethnopharmacology has documented hundreds of psychoactive plants awaiting exploitation for drug discovery. A robust and inexpensive in vivo system allowing systematic screening would be critical to exploiting this knowledge. The objective study was establish a cheap accurate method which can used testing efficacy complex mixtures unknown composition, like plant crude extracts. We automated recording zebrafish larval swimming behavior during light vs. dark periods we reproducibly altered with...
Objective The American Academy of Ophthalmology recommends a maximum hydroxychloroquine (HCQ) dose ≤5.0 mg/kg/day to reduce the risk HCQ-induced retinopathy. To determine if this adjustment would have an impact on clinical course SLE, we compared outcome measures in cohort patients with SLE before and after adjusting HCQ dose. Methods Sixty Puerto Ricans (per 1997 College Rheumatology criteria) treated who were changed studied. Visits ascertained every 6 months for 2 years (baseline visit)....
Background and Objectives: The cannabinoid receptor 2 (CB2) was previously implicated in brain functions, including complex behaviors. Here, we assessed the role of CB2 selected swimming behaviors zebrafish larvae developed an vivo upscalable whole-organism approach for ligand screening. Experimental Approach: Using CRISPR-Cas9 technology, generated a novel null allele (cnr2upr1 ) stable homozygote-viable loss-of-function (CB2-KO) line. We measured untreated wild-type cnr2upr1/upr1 larvae,...
Introduction Minority populations in the USA are disproportionately affected by cardiovascular conditions. Reduced responsiveness to clopidogrel among carriers of CYP2C19 variants has been reported patients with either coronary artery disease (CAD) or acute syndrome (ACS) after percutaneous intervention (PCI). Previous studies have evaluated genotyping-guided antiplatelet therapy selected populations; however, this yet be tested Hispanics. Given paucity clinical research on and outcomes...
Our objective was to determine the prevalence of cervical Pap screening among women living with HIV (WLWH) in Puerto Rico (P.R.) and other selected United States (U.S.) jurisdictions. Additionally, we sought compare characteristics WLWH who underwent between P.R. U.S. We analyzed data from 2018–2021 cycles CDC's Medical Monitoring Project (MMP), a national surveillance system adults residing (n = 218) 22 MMP jurisdictions 3,653). Weighted percentages 95 % confidence intervals (CIs) for were...
To assess whether genotype-guided selection of oral antiplatelet drugs using a clinical decision support (CDS) algorithm reduces the rate major adverse cardiovascular and cerebrovascular events (MACCEs) among Caribbean Hispanic patients, after 6 months.
Infections are a major cause of morbidity and mortality in systemic lupus erythematosus. Clinical outcomes erythematosus patients hospitalized due to infections vary among different ethnic populations. Thus, we determined the associated factors group Hispanics from Puerto Rico with admitted severe infections.Records Adult University Hospital, San Juan, Rico, January 2006 December 2014 were examined. Demographic parameters, manifestations, comorbidities, pharmacologic treatments, inpatient...
Abstract Introduction: Cancer is one of the most expensive medical conditions to treat due cost and duration treatment. Financial toxicity (FT) describes problems that a cancer patient has related care, including subjective financial concerns. Despite high burden cancer, significant levels poverty, fragile healthcare system in Puerto Rico (PR), no previous studies have evaluated FT among patients PR. Thus, we aimed assess associated social determinants Hispanic Methods: We are conducting...
Abstract INTRODUCTION: In 2020, Puerto Rico (PR) reported 14,168 new cancer cases and 5,354 cancer-related deaths. Timely access to diagnosis treatment are crucial for enhancing survival quality of life among patients. Our study aimed identify barriers accessing explore their association with patients selected clinical sociodemographic characteristics. METHODS: this ongoing cross-sectional study, aged 21+ years, who received active within the past year resided in PR, completed an online...
Objective This was a cross-sectional study associating vitamin D, calcium, magnesium, and potassium intakes with markers of glucose metabolism in the Hispanic Community Health Study/Study Latinos (HCHS/SOL). Methods HCHS/SOL is multicenter, prospective, population-based cohort on Hispanics/Latinos aged 18–74 years US. For this analysis, we included 10,609 participants who were free diabetes. Analysis covariance used to assess associations range micronutrient intake Homeostatic Model...
Background: Few studies have examined the use of ergogenic supplements (ESs) by young athletes residing in a sports specialized school. Methods: In this cross-sectional study, 120 students from school (ages 12–19) completed questionnaire to assess prevalence ES according sex, sport, type supplement, reasons for use, knowledge supplements, and sources information. Results: Most were males (55%) participated track field (32%). Mean age was 14.7 ± 1.6 years. Approximately 98% indicated using...
Abstract Prostate cancer (PCa) mortality in Puerto Rico (PR) is significantly higher (28.3/100,000 men) compared to US mainland Hispanics. Obesity prevalent PR and has been associated with PCa aggressiveness. Polymorphisms rs9939609 rs9930506 the FTO gene have both obesity other populations. Previous work our laboratory shown that Rican patients who underwent radical prostatectomy (RP) also had at least one G allele polymorphism exhibited a greater likelihood for low severity PCa. The aim of...
Introduction: An endogenous inhibitor of Na,K-ATPase (CTS) is increased in Dahl salt-sensitive (DS) rats and human cardiovascular pathologies. Hypothesis: Chronic hypertension a major cause CTS release which will not be corrected by treatment, that effectively treated hypertensive patients (HT) have plasma CTS, compared to ischemic stroke (STR) after thrombolytic treatment controls ( CTL). Methods: Forty (40) subjects (age sex matched) were recruited grouped into three groups: STR (n = 13),...