A5052528148- T-cell and B-cell Immunology
- Sex and Gender in Healthcare
- Diabetes and associated disorders
- Environmental Sustainability and Education
- Immune Cell Function and Interaction
- Vascular Malformations and Hemangiomas
- Cell Adhesion Molecules Research
- Education and Digital Technologies
- Immunodeficiency and Autoimmune Disorders
- Cystic Fibrosis Research Advances
- Mosquito-borne diseases and control
- Science and Science Education
- Peptidase Inhibition and Analysis
- Business and Management Studies
- Blood disorders and treatments
- Toxoplasma gondii Research Studies
- Neuropeptides and Animal Physiology
- HIV Research and Treatment
- Wastewater Treatment and Reuse
- Hematopoietic Stem Cell Transplantation
- Antimicrobial Peptides and Activities
Universidade do Estado do Rio de Janeiro
2010-2024
Karolinska Institutet
2021-2024
Fundação Oswaldo Cruz
2018-2023
Abstract The Wiskott–Aldrich syndrome protein (WASp) regulates actin cytoskeletal dynamics and function of hematopoietic cells. Mutations in the WAS gene lead to two different syndromes; (WAS) caused by loss‐of‐function mutations, X‐linked neutropenia (XLN) gain‐of‐function mutations. We previously showed that WASp‐deficient mice have a decreased number regulatory T (Treg) cells thymus periphery. here evaluated impact WASp mutations on Treg XLN mouse models. Using vitro differentiation...
VIP and PACAP are highly similar neuropeptides present in several tissues, endowed with immunoregulatory functions other systemic effects. We previously reported that both reduce viral production HIV-1-infected primary macrophages, the participation of β-chemokines IL-10, now we describe molecular mechanisms engaged this activity. Macrophages exposed to or before HIV-1 infection showed resistance replication, comparable observed when cells were treated after infection. Also, multiple...
BackgroundB-cell affinity maturation in germinal center relies on regulated actin dynamics for cell migration and cell-to-cell communication. Activating mutations the cytoskeletal regulator Wiskott-Aldrich syndrome protein (WASp) cause X-linked neutropenia (XLN) with reduced serum level of IgA.ObjectiveWe investigated role B cells XLN pathogenesis.MethodsWe examined from 6 patients, 2 whom had novel R268W S271F WASp. By using immunized mouse models that carry corresponding patient mutations,...
O fechamento das escolas durante a pandemia gerou graves consequências nos níveis de aprendizado, principalmente entre os alunos do ensino fundamental redes públicas ensino. Com apoio da FAPERJ através Edital nº 45/2021 – Apoio à melhoria rede pública sediadas no estado Rio Janeiro, pesquisadores Programa Pós-Graduação em Biociências-UERJ lideraram projetos diferentes localidades estado, visando contribuir para ampliação dos índices aprendizado e difusão conhecimento científico estudantes...
Here, we describe new findings related to the ability of cytokine IL-27 regulate growth HIV-1 in CD4 + T lymphocytes. has long been considered a potent inhibitor replication, notion based on several reports showing that this controls infection peripheral blood mononuclear cells (PBMCs), monocyte-derived macrophages, and dendritic cells.
Destinar adequadamente o lixo é um dos grandes desafios da administração pública em vários países. Diante disso, no Campus Regional de Resende, Universidade do Estado Rio Janeiro, está sendo desenvolvido projeto extensão visando a implantação Coleta Seletiva Solidária resíduos recicláveis. Este texto visa relatar esta experiência e, para sua realização, empregou-se método gestão conhecido como PDCA (Plan, Do, Check, Act). O levantamento dados foi feito cada setor identificar os principais...
Comunidades rurais, de forma geral, apresentam problemas em relacao a qualidade da agua que e utilizada para consumo, preparo alimentos higiene, pois essa pode estar contaminada com micro-organismos patogenos provenientes materia fecal outras fontes poluicao. Um metodo se tem mostrado eficaz colocar dentro dos padroes microbiologicos aceitaveis consumo desinfeccao solar (SODIS). Visando difundir o comunidades fins prover uma alternativa pratica baixo custo, foi desenvolvido guia professores...