A5058408677- Functional Brain Connectivity Studies
- Cell Image Analysis Techniques
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Biomedical Text Mining and Ontologies
- Neuroinflammation and Neurodegeneration Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Scientific Computing and Data Management
- Bioinformatics and Genomic Networks
- Memory and Neural Mechanisms
- Advanced Fluorescence Microscopy Techniques
- Computational Drug Discovery Methods
- Zebrafish Biomedical Research Applications
- Health, Environment, Cognitive Aging
- Trace Elements in Health
- Single-cell and spatial transcriptomics
- Advanced Neuroimaging Techniques and Applications
- Medical Image Segmentation Techniques
- Alzheimer's disease research and treatments
- Meta-analysis and systematic reviews
- Neuroendocrine regulation and behavior
University of Oslo
2018-2024
Norwegian University of Science and Technology
2017-2023
Kavli Institute for Systems Neuroscience
2023
Volumetric brain atlases are increasingly used to integrate and analyze diverse experimental neuroscience data acquired from animal models, but until recently a publicly available digital atlas with complete coverage of the rat has been missing. Here we present an update Waxholm Space atlas, comprehensive open-access volumetric resource. This features annotations 222 structures, which 112 new 57 revised compared previous versions. It provides detailed map cerebral cortex, hippocampal region,...
Alzheimer's disease (AD) is broadly characterized by neurodegeneration, pathology accumulation, and cognitive decline. There considerable variation in the progression of clinical symptoms humans, highlighting importance genetic diversity study AD. To address this, we analyze cell composition amyloid-beta deposition 6- 14-month-old AD-BXD mouse brains. We utilize analytical QUINT workflow- a suite software designed to support atlas-based quantification, which expand deliver highly effective...
The hippocampus in mammals is a morphologically well-defined structure, and so are its main subdivisions. To define the homologous structure other vertebrate clades, using these morphological criteria has been difficult, if not impossible, since typical mammalian morphology absent. Although there seems to be consensus that most medial part of pallium represents all vertebrates, no on whether hippocampal subdivisions present derivatives groups. aim this paper explore potential relevance...
Brain atlases are widely used in neuroscience as resources for conducting experimental studies, and integrating, analyzing, reporting data from animal models. A variety of available, it may be challenging to find the optimal atlas a given purpose perform efficient atlas-based analyses. Comparing findings reported using different is also not trivial, represents barrier reproducible science. With this perspective article, we provide guide how mouse rat brain can analyzing accordance with FAIR...
Neuroscientists employ a range of methods and generate increasing amounts data describing brain structure function. The anatomical locations from which observations or measurements originate represent common context for interpretation, starting point identifying interest. However, the multimodality abundance pose challenge efforts to organize, integrate, analyze based on locations. While structured metadata allow faceted queries, different types are not easily represented in standardized...
In experimental neuroscientific research, anatomical location is a key attribute of observations and critical for interpretation results, replication findings, comparison data across studies. With steadily rising numbers publications reporting basic there an increasing need integration synthesis data. Since relies on consistently defined locations, it major concern that practices precision in the from different types studies seem to vary considerably. To elucidate possibly meet this...
Brain atlases are important reference resources for accurate anatomical description of neuroscience data. Open access, three-dimensional serve as spatial frameworks integrating experimental data and defining regions-of-interest in analytic workflows. However, naming conventions, parcellation criteria, area definitions, underlying mapping methodologies differ considerably between across atlas versions. This lack standardized impedes use tools registration to different atlases. To establish a...
Abstract Volumetric brain atlases are increasingly used to integrate and analyse diverse experimental neuroscience data acquired from animal models, but until recently a publicly available digital atlas with complete coverage of the rat has been missing. Here we present new Waxholm Space atlas, comprehensive open-access volumetric resource. This full features annotations 222 structures, which 112 57 revised compared previous versions. It maps in detail cerebral cortex, hippocampal region,...
Abstract The hippocampal formation and entorhinal cortex are crucially involved in learning memory as well spatial navigation. conservation of these structures across the entire mammalian lineage demonstrates their importance. Information on a diverse set spatially tuned neurons has become available, but we only have rudimentary understanding how anatomical network structure affects functional tuning. Bats order mammals that evolved true flight, with this specialization comes need to...
Abstract Studies of the adult mouse brain have benefited from three-dimensional atlases providing a standard frame reference for data analysis and integration. Extending these resources to developing has been challenging due need integrate time as dimension atlas. To address this, we present Developmental Mouse Brain Atlas, four-dimensional atlas encompassing each postnatal day 4 56.
Abstract The ability of Timm’s sulphide silver method to stain zincergic terminal fields has made it a useful neuromorphological marker. Beyond its roles in zinc-signalling and neuromodulation, zinc is involved the pathophysiology ischemic stroke, epilepsy, degenerative diseases neuropsychiatric conditions. In addition visualising fields, also labels transition metals neuronal perikarya glial cells. To provide benchmark reference for planning interpretation experimental investigations...
Abstract Brain atlases are important reference resources for accurate anatomical description of neuroscience data. Open access, three-dimensional serve as spatial frameworks integrating experimental data and defining regions-of-interest in analytic workflows. However, naming conventions, parcellation criteria, area definitions, underlying mapping methodologies differ considerably between across atlas versions. This lack standardization impedes use tools registration to different atlases. To...
Abstract Alzheimer’s disease (AD) is characterized by neurodegeneration, pathology accumulation, and progressive cognitive decline. There significant variation in age at onset severity of symptoms highlighting the importance genetic diversity study AD. To address this, we analyzed cell composition 6- 14-month-old AD-BXD mouse brains using semi-automated workflow (QUINT); which expanded to allow for nonlinear refinement brain atlas-registration, quality control assessment atlas-registration...
The spatial pattern of transgene expression in tetracycline-controlled mouse models is governed primarily by the driver line used to introduce transactivator (tTA). Detailed maps showing where each tTA activates are therefore essential for designing and using tet-regulated models, particularly brain research cell type regional specificity determine circuits affected conditional gene expression. We have compiled a comprehensive online repository serial microscopic images brain-wide reporter...