A5035124537- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Luminescence and Fluorescent Materials
- Supramolecular Chemistry and Complexes
- Surface Chemistry and Catalysis
- Photochromic and Fluorescence Chemistry
- Photoreceptor and optogenetics research
- Advanced Fluorescence Microscopy Techniques
- Synthetic Organic Chemistry Methods
- Molecular Junctions and Nanostructures
- Synthesis and Properties of Aromatic Compounds
- Porphyrin and Phthalocyanine Chemistry
- Organometallic Complex Synthesis and Catalysis
- Asymmetric Synthesis and Catalysis
- Catalytic Alkyne Reactions
- Chemical synthesis and alkaloids
- Cyclization and Aryne Chemistry
- Metal-Organic Frameworks: Synthesis and Applications
- Organometallic Compounds Synthesis and Characterization
- Magnetism in coordination complexes
- Molecular Sensors and Ion Detection
- Cancer Treatment and Pharmacology
- Ferrocene Chemistry and Applications
- Retinal Development and Disorders
University of Oxford
2015-2020
Polish Academy of Sciences
2020
Institute of Organic Chemistry
2020
Science Oxford
2016-2020
Australian National University
2015-2019
Canberra (United Kingdom)
2019
Oxfam
2018
Oxford Research Group
2016
We demonstrate that a photochromic spironaphthoxazine switch operates with excellent fatigue resistance and high conversion when irradiated at 405/561 nm in range of media including living cells.
The synthesis of an all-halogen-bonding rotaxane for anion recognition is achieved by using active-metal templation. A flexible bis-iodotriazole-containing macrocycle exploited the metal-directed synthesis. Endotopic binding a Cu(I) template facilitates CuAAC iodotriazole axle formation reaction that captures interlocked product. Following copper-template removal, exotopic coordination more sterically demanding rhenium(I) complex induces inversion in conformation component, directing...
The synthesis of a small-molecule dyad consisting far-red-emitting silicon rhodamine dye that is covalently linked to photochromic spironaphthothiopyran unit, which serves as photoswitchable quencher, reported. This system can be switched reversibly between the fluorescent and nonfluorescent states using visible light at wavelengths 405 630 nm, respectively, it works effectively in aqueous solution. Live-cell imaging demonstrates this has several desirable features, including excellent...
We have employed the scanning tunneling microscope break-junction technique to investigate single-molecule conductance of a family 5,15-diaryl porphyrins bearing thioacetyl (SAc) or methylsulfide (SMe) binding groups at ortho position phenyl rings (S2 compounds). These substituents lead two atropisomers, cis and trans, for each compound, which do not interconvert in solution under ambient conditions; even high temperatures, isomerization takes several hours (half-life 15 h 140 °C SAc...
A photoswitchable quencher can be used to reversibly turn off the emission from a fluorescent dye, generating small molecule dyad that is effective for super-resolution RESOLFT microscopy.
Abstract Polyyne polyrotaxanes, encapsulated cyclocarbon catenanes and other fascinating mechanically interlocked carbon‐rich architectures should become accessible if masked alkyne equivalents (MAEs) can be developed that are large enough to prevent unthreading of a macrocycle, cleanly unmasked under mild conditions. Herein, we report the synthesis new bulky MAE based on t ‐butylbicyclo[4.3.1]decatriene. This was used synthesize polyyne [2]rotaxane masked‐polyyne [3]rotaxane by...
The successive treatment of [W(CO)6] with LiSiPh3, (OCBr)2, and 4-picoline (pic) affords the silylcarbyne complex [W(≡CSiPh3)Br(CO)2(pic)2], which reacts 1,2-bis(dicyclohexylphoshino)ethane (dcpe), 1,2-bis(diphenylphosphino)ethane (dppe), tetramethylethylenediamine (tmeda) to provide complexes [W(≡CSiPh3)Br(CO)2(L2)] (L2 = dcpe, dppe, tmeda). Fluoride-mediated protodesilylation [W(≡CSiPh3)Br(CO)2(dcpe)] moist [Bu4N]F provides stable structurally characterized terminal methylidyne...
Extended triisopropylsilyl end-capped polyynes have been prepared from the corresponding tetracobalt complexes by removing complexed dicobalt tetracarbonyldiphenylphosphinomethane (Co2(CO)4dppm) moieties. Unmasking of this "masked alkyne equivalent" was achieved under mild conditions with elemental iodine at room temperature, making it possible to obtain fragile up 20 contiguous sp-hybridized carbon atoms. The Co2(CO)4dppm moiety has a strong geometric and steric effect on polyyne but does...
Strapped or "basket-handle" porphyrins have been investigated previously as hemoglobin mimics and catalysts. The facial selectivity of their interactions with axial ligands is a sensitive test for noncovalent bonding. Here the binding pyridyl to zinc thioester-linked alkyl straps in solution by NMR spectroscopy UV-vis titration, solid state X-ray crystallography. We expected that coordination ligand would occur on less hindered face porphyrin, away from strap. Surprisingly, attractive...
Abstract Polyyne polyrotaxanes, encapsulated cyclocarbon catenanes and other fascinating mechanically interlocked carbon‐rich architectures should become accessible if masked alkyne equivalents (MAEs) can be developed that are large enough to prevent unthreading of a macrocycle, cleanly unmasked under mild conditions. Herein, we report the synthesis new bulky MAE based on t ‐butylbicyclo[4.3.1]decatriene. This was used synthesize polyyne [2]rotaxane masked‐polyyne [3]rotaxane by...
The reactions of 1-tert butyl-5-thiotetrazole (HtttBu) with Na[BH4] provides Na[H2B(tttBu)2] (Na[1]) or Na[HB(tttBu)3] (Na[2]) in refluxing THF xylene, respectively. Treating [RuCl(Ph)(CO)(PPh3)2] Na[2] affords the triply-buttressed ruthenaboratrane [Ru(CO)(PPh3){κ4-B,S,S',S''-B(tttBu)3}] (5) whilst Na[1] [IrCl(CO)(PPh3)2] rare examples doubly-buttressed metallaboratranes [IrH(CO)(PPh3){κ3-B,S,S'-BH(tttBu)2}] (7) and [Ru(CO)(PPh3)2{κ3-B,S,S'-BH(tttBu)2}] (12), latter via isolable...
Review: 55 refs.