A5087730140- Advanced biosensing and bioanalysis techniques
- Light effects on plants
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Photoreceptor and optogenetics research
- Psychological Well-being and Life Satisfaction
- Monoclonal and Polyclonal Antibodies Research
- Bacteriophages and microbial interactions
- bioluminescence and chemiluminescence research
- Pancreatic and Hepatic Oncology Research
- Microfluidic and Bio-sensing Technologies
- Radioactive element chemistry and processing
- COVID-19 and Mental Health
- Nanoparticle-Based Drug Delivery
- Electrohydrodynamics and Fluid Dynamics
- DNA and Nucleic Acid Chemistry
- Boron Compounds in Chemistry
- Biochemical and Structural Characterization
- RNA Interference and Gene Delivery
- Radiopharmaceutical Chemistry and Applications
- Algal biology and biofuel production
- Virus-based gene therapy research
- Mindfulness and Compassion Interventions
- Photosynthetic Processes and Mechanisms
- Enzyme Catalysis and Immobilization
Karlsruhe Institute of Technology
2022-2024
Philipps University of Marburg
2020-2023
University of Würzburg
2023
Heriot-Watt University
2021
The University of Texas Medical Branch at Galveston
1983
The University of Texas Health Science Center at San Antonio
1983
Pancreatic ductal adenocarcinoma (PDAC) has a devastating prognosis without effective treatment options. Thus, there is an urgent need for more and safe therapies. Here, inorganic-organic hybrid nanoparticles (GMP-IOH-NPs) are presented as novel drug-delivery system the selective delivery of extraordinarily high concentrations gemcitabine monophosphate (GMP), not only to primary tumor but also metastatic sites. GMP-IOH-NPs have composition [ZrO]2+ [GMP]2- with GMP drug anion (76% total...
Abstract Exploring the potential of microfluidic systems, this study presents a groundbreaking approach harnessing energy in flows within purpose‐built microreactor, enabling precise deposition functional biomaterials. Upon optimizing reactor dimensions and integrating it into system, sequentially flow‐induced DNA hydrogels transformation DNA‐protein hybrid materials with SpyTag/SpyCatcher technology is investigated. However, limited functionalization rates restrict its viability for...
The immunological response of mast cells is controlled by the multivalent binding antigens to immunoglobulin E (IgE) antibodies bound high-affinity receptor FcεRI on cell membrane surface. However, spatial organization antigen-antibody-receptor complexes at nanometer scale and structural constraints involved in initial events surface are not yet fully understood. For example, it unclear what influence affinity nanoscale distance between partners have activation degranulate inflammatory...
The worldwide COVID-19 pandemic may have negative impacts on individuals' mental health. At the same time, protective factors such as mindfulness, i.e., a moment-to-moment awareness of own experiences without judgment, positive effects various psychological outcomes during pandemic.The current study analyzed associations between trait mindfulness and at three measurement points, testing self-efficacy coping strategies further potential predictors.Altogether 207 students (85% female, mostly...
Accurate quantification of polymerized DNA in rolling circle amplification (RCA)-based hydrogels is challenging due to the high viscosity these materials, however, it can be achieved with a photometric nucleotide depletion assay or qPCR. We show that content strongly depends on template sequence and correlates mechanical properties hydrogels.
Abstract Photolyases are ubiquitously occurring flavoproteins for catalyzing photo repair of UV-induced DNA damages. All photolyases described so far have a bilobal architecture with C-terminal domain comprising flavin adenine dinucleotide (FAD) as catalytic cofactor and an N-terminal capable harboring additional antenna chromophore. Using sequence-similarity network analysis we discovered novel subgroup the photolyase/cryptochrome superfamily (PCSf), NewPHLs. NewPHL occur in bacteria...
We present an efficient and readily applicable strategy for the covalent ligation of proteins to DNA origami by using SpyCatcher-SpyTag (SC-ST) connector system. This approach showed orthogonality with other connectors has been used exemplarily immobilization study stereoselective ketoreductases gain insight into spatial arrangement enzymes on nanostructures.
Cryptochromes are a ubiquitously occurring class of photoreceptors. Together with photolyases, they form the Photolyase Cryptochrome Superfamily (PCSf) by sharing common protein architecture and binding mode FAD chromophore. Despite these similarities, PCSf members exert different functions. Photolyases repair UV-induced DNA damage photocatalytically driven electron transfer between FADH
Traditionally, the use of DNA origami nanostructures (DONs) to study early cell signaling processes has been conducted using standard laboratory equipment with DONs typically utilized in solution. Surface-based technologies simplify microscopic analysis cells treated DON agents by anchoring them solid substrates, thus avoiding complications receptor-mediated endocytosis. A robust microfluidic platform for real-time monitoring and precise functionalization surfaces was developed here. The...
Photolyases are flavoproteins, which able to repair UV-induced DNA lesions in a light-dependent manner. According their substrate, they can be distinguished as CPD- and (6-4) photolyases. While CPD-photolyases the predominantly occurring cyclobutane pyrimidine dimer lesion, photolyases catalyze of less prominent photoproduct. The subgroup prokaryotic photolyases/FeS-BCP is one most ancient types flavoproteins ubiquitously photolyase & cryptochrome superfamily (PCSf). In contrast canonical...
Research Articles| November 06 2008 Studies of Human Urinary Protein Fragments from Extracellular Matrix Proteins: A Progress Report Subject Area: Cardiovascular System , Nephrology L.W. Schneider; Schneider University Texas Health Science Center, San Antonio, Tex., USA; Medical Branch, Galveston, USA Search for other works by this author on: This Site PubMed Google Scholar D.R. Barnett; Barnett S.D. Carson; Carson R.M. Goldblum; Goldblum P.H. van Bragt; Bragt H.J.A. Brejwo; Brejwo J.D....
Virus-Based Pyroelectricity Viruses lack the machinery to directly sense and respond heat, but they can undergo structural adaptations in response temperature changes. In article number 2305503, Seung-Wuk Lee co-workers present discovery of pyroelectric potential generation within a virus delve into intricate molecular mechanisms underpinning viral pyroelectricity using genetic engineering Kelvin probe force microscopy techniques.