A5086675607- Molecular Biology Techniques and Applications
- Cervical Cancer and HPV Research
- Cancer Cells and Metastasis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- AI in cancer detection
- Pharmacological Effects of Natural Compounds
- Enterobacteriaceae and Cronobacter Research
- Systemic Sclerosis and Related Diseases
- Cell Image Analysis Techniques
- Urinary and Genital Oncology Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bladder and Urothelial Cancer Treatments
- Lymphadenopathy Diagnosis and Analysis
Local Initiatives Support Corporation
2021
CellDetect® is a unique platform technology comprising proprietary plant extract and 3 dyes that enables color discrimination between malignant (red) benign (green) cells based on specific metabolic alterations exclusive to the former. Preclinical studies clinical trials demonstrated applicability of new in many cell culture lines various cancers. We explored its performance characteristics bladder cancer.We performed an open label, 2-step study at tertiary medical centers. The enrolled...
Advanced diagnostic tools stand today at the heart of successful cancer treatment. CellDetect(R) is a new histochemical staining technology that enables color discrimination between normal cells and wide variety neoplastic tissues. Using this technology, are colored blue/green, while red. This tinctorial difference coincides with clear morphological visualization properties, mainly in tissue samples. Here we show can be deployed to distinguish from transformed most significantly detect their...
Abstract Although cytological screening for cervical neoplasia has lowered mortality rates, current methods are plagued by sub‐optimal sensitivity and/or specificity. The purpose of this study was to compare the performance new CellDetect® staining technology as a potential tool. This initial, non‐blinded study, utilized samples taken at community‐based clinic. diagnostic results using were compared with Pap and human papilloma virus (HPV) testing on same material, well follow‐up biopsies....
A persistent goal of oncologic histochemistry is to microscopically identify neoplasia tinctorially. Consequently, the newly developed CellDetect® staining technology, that appears exhibit this property, warrants clinical evaluation. The objective study was compare diagnostic results using outcomes standard microscopic examination based on hematoxylin and eosin (H&E) for recognition different squamous epithelial phenotypes uterine cervix. Pairs adjacent sections were made from 60 cervical...
AbstractAbstractZetiq has introduced a histochemical stain that claims to tinctorially identify cancer and neoplastic cells. Because of the potential importance such capability, we undertook investigate Zetiq's CellDetect® staining technology as applied cultured cell lines well an initial sample clinical cases. This goal was pursued by investigating four types comparisons: 1) before after differentiation; 2) cervical squamous-cell carcinoma (SCC) biopsies non-neoplastic squamous epithelium;...
<title>Abstract</title> Background In this study, we examined in a proprietary vitro system the antifibrotic properties of lithium and its modulating effect on telomere maintenance telomerase activity. Lithium effects were compared with FDA-approved drugs for treatment Idiopathic pulmonary fibrosis. Methods three different concentrations, Nintedanib Pirfenidone tested InMatrico IPF assay (Xylyx Bio) using decellularized extracellular matrix obtained from human lung fibrosis added primary...
Abstract Background: Idiopathic pulmonary fibrosis remains an incurable disease with poor prognosis. Recently the focus in research on possible pathogenesis of this debilitating illness has shifted, at least part, to premature accelerated aging lung tissue as a driving force leading fibrosis. Telomere shortening marker aging, may play important role approach understand idiopathic pathophysiology. The goal study was test effect inhaled lithium fibrosis, potential new treatment modality....