A5023526285- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive biology and impacts on aquatic species
- Liver Diseases and Immunity
- Liver physiology and pathology
- Animal Behavior and Reproduction
- Neuroendocrine regulation and behavior
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Stress Responses and Cortisol
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hepatitis Viruses Studies and Epidemiology
- Systemic Lupus Erythematosus Research
- Pluripotent Stem Cells Research
- Endoplasmic Reticulum Stress and Disease
- Organ Transplantation Techniques and Outcomes
- T-cell and B-cell Immunology
- Pediatric Hepatobiliary Diseases and Treatments
- Physiological and biochemical adaptations
- Inflammasome and immune disorders
- Reproductive System and Pregnancy
- Aquaculture Nutrition and Growth
Yale University
2013-2023
Weatherford College
2017
Cornell University
2009-2011
Early-life stress caused by the deprivation of maternal care has been shown to have long-lasting effects on hypothalamic–pituitary–adrenal (HPA) axis in offspring uniparental mammalian species. We asked if biparental species alters responsiveness offspring, using a avian species—the zebra finch, Taeniopygia guttata . In our experiment, one group birds was raised both male and female parents (control), another males alone (maternally deprived). During adulthood, groups were subjected two...
A subset of human regulatory T cells (Tregs) can secrete IFN-γ or IL-17, and thus share features TH1 TH17 effector lose suppressive function. The main factors driving this differentiation Tregs toward a proinflammatory phenotype include IL-12 for TH1-like IL-6 TH17-type Tregs. In study we show that patients with de novo autoimmune hepatitis (dAIH) display increased frequencies IL-17 cytokines. Irrespective fully demethylated FOXP3 locus, subjects dAIH are functionally impaired. line the...
Abstract Background Corticosteroid receptors include mineralocorticoid (MR) and glucocorticoid (GR) receptors. Teleost fishes have a single MR duplicate GRs that show variable sensitivities to mineralocorticoids glucocorticoids. How these compare functionally tetrapod GR, the evolutionary significance of maintaining two GRs, remains unclear. Results We used up seven steroids (including aldosterone, cortisol 11-deoxycorticosterone [DOC]) ligand specificity binding domains corticosteroid...
De novo autoimmune hepatitis (DAIH) is an important cause of late allograft dysfunction after liver transplantation, but its and underlying pathogenesis remains unclear. We sought to identify specific innate adaptive immune mechanisms driving the pro-inflammatory cytokine secreting regulatory T cell phenotype in DAIH determine if modulation these pathways could resolve inflammatory milieu observed livers patients with DAIH. Here we demonstrate Toll-like receptors 2 & 4 mediated Inflammasome...
Elucidating the molecular mechanisms involved in differentiation of stem cells to hepatic is critical for both understanding normal developmental processes as well optimizing generation functional therapy. We performed vitro mouse embryonic (mESCs) with a null mutation homeobox gene Hhex and show that Hhex-/- mESCs fail differentiate from definitive endoderm (Sox17+/Foxa2+) (Alb+/Dlk+). In addition, culture elicited >7-fold increase Vegfa mRNA expression compared Hhex+/+ cells. Furthermore,...
Regulatory T cells (Tregs) are not terminally differentiated but can acquire effector properties. Here we report an increased expression of human endogenous retrovirus 1 (HERV1-env) proteins in Tregs patients with de novo autoimmune hepatitis and hepatitis, which induces endoplasmic reticulum (ER) stress. HERV1-env-triggered ER stress activates all three branches (IRE1, ATF6, PERK) the unfolded protein response (UPR). Our coimmunoprecipitation studies show interaction between HERV1-env ATF6...