A5024088150- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Immune Response and Inflammation
- SARS-CoV-2 and COVID-19 Research
- Diabetes and associated disorders
- Galectins and Cancer Biology
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Hepatitis C virus research
- Sphingolipid Metabolism and Signaling
- Atherosclerosis and Cardiovascular Diseases
- T-cell and Retrovirus Studies
- Long-Term Effects of COVID-19
- Animal Disease Management and Epidemiology
- Genetic factors in colorectal cancer
- Vector-Borne Animal Diseases
- Monoclonal and Polyclonal Antibodies Research
- Glioma Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Helicobacter pylori-related gastroenterology studies
- Psoriasis: Treatment and Pathogenesis
- CAR-T cell therapy research
- interferon and immune responses
Imperial College London
2020-2024
Faculty (United Kingdom)
2024
Karolinska Institutet
2011-2022
Yale University
2011-2020
Universidad de Cádiz
2007-2017
Biomedical Research and Innovation Institute of Cadiz
2017
Instituto de Investigación Biomédica de A Coruña
2017
Harvard University
2010-2015
Brigham and Women's Hospital
2010-2015
Massachusetts Institute of Technology
2014
Abstract T cell Ig and ITIM domain (TIGIT) is a newly identified receptor expressed on cells that binds to CD155 the dendritic surface, driving them more tolerogenic phenotype. Given TIGIT contains an motif in its intracellular considering potential importance of TIGIT/CD226 pathway human autoimmune disease, we investigated specific role CD4+ cells. Using agonistic anti-TIGIT mAb, demonstrate direct inhibitory effect proliferation with decrease expression T-bet, GATA3, IFN regulatory factor...
T-cell immunoglobulin and mucin domain 3 (TIM-3) is an Ig-superfamily member expressed on IFN-γ-secreting Th1 Tc1 cells was identified as a negative regulator of immune tolerance. TIM-3 by subset activated CD4(+) T cells, anti-CD3/anti-CD28 stimulation increases both the level expression number TIM-3(+) cells. In mice, constitutively natural regulatory (Treg) has been molecule alloimmunity through its ability to modulate differentiation. Here, we examined human Treg determine role in...
Differences in TLR7 and TLR8 signaling program virus-specific responses of human monocytes to infection.
Th1 Tregs are characterized by the acquisition of proinflammatory cytokine secretion and reduced suppressor activity. found at increased frequency in autoimmune diseases, including type 1 diabetes multiple sclerosis (MS). We have previously reported that vitro stimulation with IL-12 recapitulates functional molecular features MS-associated Tregs, revealing a central role for hyperactivation Akt pathway their induction. TIGIT is newly identified coinhibitory receptor marks specifically...
FOXP3+ Tregs rely on fatty acid β-oxidation-driven (FAO-driven) oxidative phosphorylation (OXPHOS) for differentiation and function. Recent data demonstrate a role in the maintenance of tissue homeostasis, with tissue-resident possessing tissue-specific transcriptomes. However, specific signals that establish Treg programs remain largely unknown. metabolically FAO, considering lipid-rich environments tissues, we hypothesized environmental lipids drive homeostasis. First, using human adipose...
Abstract Although alterations in myeloid cells have been observed COVID-19, the specific underlying mechanisms are not completely understood. Here, we examine function of classical CD14 + monocytes patients with mild and moderate COVID-19 during acute phase infection healthy individuals. Monocytes from display altered expression cell surface receptors a dysfunctional metabolic profile that distinguish them monocytes. Secondary pathogen sensing ex vivo leads to defects pro-inflammatory...
Studying the activity of homogeneous regulatory T cell (Treg) populations will advance our understanding their mechanisms action and role in human disease. Although isolating Tregs exhibiting low expression CD127 markedly increases purity, resulting Treg are still heterogeneous. To examine complexity defined by phenotype comparison with previously described CD4(+)CD25(hi) subpopulations, we subdivided CD25(hi) population memory into subsets based on HLA-DR. These exhibited differences...
Abstract In autoimmune patients, regulatory T cells (Tregs) are increasingly found to be unable suppress patient-derived cells, an outcome referred as Treg resistance. this study, we show that CD4 from patients with multiple sclerosis resist suppression by or healthy donor–derived ex vivo Tregs. Importantly, report granzyme B (GzmB) contributes resistance via a novel, apoptosis-independent mechanism. We memory CD4+CD127loFOXP3+ subsets do not express GzmB, whereas activated, nonregulatory...
Prostaglandin E2 (PGE2) promotes Th17 expansion while otherwise inhibiting other CD4+ T cell subsets. Here, we identified a PGE2-dependent pathway that induces pathogenic cells in autoimmune disease and is regulated by the transcription factor RORC. Compared with types from healthy subjects, there surprising lack of prostaglandin receptor EP2 on cells; therefore, examined hypothesis RORγt, which highly expressed cells, mediates downregulation. Chromatin immunoprecipitation followed DNA...
Adaptive T cell responses are critical for controlling HCV infection. While there is clinical evidence of a relevant role regulatory cells in chronic HCV-infected patients, based on their increased number and function; mechanisms underlying such phenomena still poorly understood. Accumulating suggests that proteins from Hepatitis C virus can suppress host immune responses. We others have shown present CD4+ lymphocytes chronically infected patients HCV-core protein induces state...
Type 1 and type 2 diabetes are associated with increased severity mortality from respiratory virus infections, including SARS-CoV-2. Vaccination in the general population significantly reduces risk of severe viral infection triggers a strong, polyfunctional lasting T cell response healthy individuals. However, vaccine effectiveness people is unclear. Here we studied magnitude functional characteristics vaccine-specific CD4+ CD8+ responses to full vaccination protocol, recall after third...