Abstract Glutathione‐ S ‐transferases (GSTs) are upregulated in malignant gliomas and contribute to their chemoresistance. The nitric oxide (NO) donor PABA/NO (O 2 ‐{2,4‐dinitro‐5‐[4‐( N ‐methylamino)benzoyloxy]phenyl} 1‐( , ‐dimethylamino)diazen‐1‐ium‐1,2‐diolate) generates NO upon selective enzymatic activation by GST‐π‐inducing biological effects tumors. Tumor cell killing chemosensitization were observed a variety of tumors after exposure GST‐activated drugs. In our project, cytotoxic...

BACKGROUND: Glutathione S-transferases (GSTs) control multidrug resistance and are upregulated in many cancers, including malignant gliomas. The diazeniumdiolate JS-K generates nitric oxide (NO) on enzymatic activation by glutathione GST, showing promising NO-based anticancer efficacy. OBJECTIVE: To evaluate the role of antitumor therapy with U87 gliomas vitro vivo. METHODS: glioma cells primary glioblastoma cell lines were exposed to a variety inhibitors study death necrosis, apoptosis,...

Purpose . To assess the frequency, risk factors, and management of accidental durotomy in minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). Methods This single‐center study retrospectively investigates 372 patients who underwent MIS TLIF were mobilized within 24 hours after surgery. The frequency durotomies, intraoperative closure technique, body mass index, history previous surgery was recorded. Results We identified 32 durotomies 514 levels (6.2%). Analysis showed a...

The aim of the study was to investigate safety and efficacy minimally invasive tubular microdiscectomy for treatment recurrent lumbar disc herniation (LDH). As opposed endoscopic techniques, namely microendoscopic transforaminal discectomy, this microscopically assisted technique has never been used LDH.Thirty consecutive patients who underwent LDH were included in study. preoperative postoperative visual analog scale (VAS) scores pain, clinical outcome according modified Macnab criteria,...

Purpose . To compare radiographic and clinical outcomes after anterior cervical discectomy in patients with degenerative disc disease using PEEK cages or PMMA spacers a minimum 1-year follow-up. Methods Anterior was performed 107 one two levels empty (51 levels), Sulcem (49 levels) Palacos (41 between January, 2005 February, 2009. Bony fusion, subsidence, sagittal alignment were retrospectively assessed CT scans radiographs at Clinical outcome measured the VAS, NDI, SF-36. Results fusion 65%...

A radiation exposure study in vitro.This aimed to compare the of 2 different 3-dimensional (3D) C-arm devices on an anthropomorphic phantom.Minimally invasive pedicle screw placement requires intraoperative imaging techniques for visualization unexposed spine. Mobile 3D C-arms compose a image data set out multiple successive fluoroscopic images.We compared Siremobil Iso-C (Siemens Sector Healthcare, Erlangen, Germany) and Vision FD Vario (Ziehm Imaging, Nuremberg, regarding their exposure....

Retrospective case-control study.To compare the incidence, management, and outcome of incidental durotomy in revision microdiscectomy with open minimal-access surgery.Incidental occurs a variable incidence 3%-27% spine surgery. The highest rate microdiscectomy. intraoperative postoperative management dural tears varies literature definite impact on clinical has to be clarified.This is retrospective study medical records 135 patients who underwent microdiscectomy, divided into 2 subgroups:...

The authors report a very rare cause of low-back pain and sciatica in patient with iliac vein thrombosis attributed to absence the infrarenal segment inferior vena cava (IVC) massively dilated venous collaterals draining via paraspinal plexus into azygous system. This 21-year-old man presented acute radiating left ventral thigh. initial CT scan revealed an intraspinal lesion that mimicked lumbar disc herniation. Further clarification thrombosis, which was triggered by IVC, vascular anomaly....

To describe the minimally invasive technique for cement augmentation of cannulated and fenestrated screws using an injection cannula as well to report its safety efficacy.A total 157 pedicle had been cement-augmented during posterior screw-rod spondylodesis in 35 patients from January December 2012. Retrospective evaluation extravasation screw loosening was carried out postoperative plain radiographs thin-sliced triplanar computed tomography scans.Twenty-seven, largely prevertebral...

Retrospective cohort study.Assessment of outcome after minimally invasive posterior cervical foraminotomy (MI-PCF).Surgical management radiculopathy represents a controversial area in spinal surgery. Preferred approaches include both anterior discectomy and (PCF). Numerous studies showed comparable results. Employing PCF eliminates risks associated with approach. as originally described by Spurling Scoville necessitates extensive stripping muscles to expose the spine, resulting muscle...

After surgery for intractable mesiotemporal lobe epilepsy (mTLE) seizures recur in 30-40%. One predictor seizure recurrence is the distribution of onset and interictal epileptiform discharges (IED). Our study focused on lateralization extent activity regarding postoperative persistence effect reoperation.This comprises 426 consecutive patients operated mTLE. Impact preoperative IED results reoperation were analyzed.One year after surgery, 27% with mTLE experienced persistent (Engel II-IV)....

Some symptomatic degenerative conditions of the lumbar spine may be treated with spinal fusion if conservative treatment has failed. The minimally invasive technique transforaminal interbody (MIS TLIF) is increasingly used but been found to generate increased radiation exposure patient and staff. Modern three-dimensional (3D) C-arm devices are capable providing conventional two-dimensional fluoroscopic images (x-rays) as well 3D image sets for intraoperative navigation. This study was...

Abstract BACKGROUND Although multilobar resections correspond to one-fifth of pediatric epilepsy surgery, there are little data on long-term seizure control. OBJECTIVE To investigate the outcomes children and adolescents undergoing surgery identify their predictors. METHODS In this retrospective study, we considered 69 consecutive patients that underwent at age 10.0 ± 5.0 yr (mean SD). The magnetic resonance imaging revealed a lesion in all but 2 cases. Resections were...

<b>Purpose:</b> To evaluate the effectiveness and safety of percutaneous vesselplasty in pathological vertebral fractures thoracolumbar spine selected tumor patients. <b>Materials Methods:</b> Eleven nine patients were treated with (Vessel-X^®, MAXXSPINE). Nine eleven vertebras (81.8 %) had major posterior wall deficiency (> 30 %). Clinical radiological (CT) measures obtained before 3 months after procedure. <b>Results:</b> The mean VAS improved significantly from preoperative to...

This was a retrospective analysis.This study compares 2 different 3-dimensional (3D) C-arm devices for intraoperative imaging and navigation with regard to clinical applicability image quality.Minimally invasive spine surgery requires techniques adequately visualize the unexposed spine. For this purpose, mobile 3D C-arms became available along evolution of techniques.The Siremobil Iso-C (Siemens) Vision FD Vario (Ziehm) perform an automated orbital rotation around patient acquiring set out...

This paper aims to demonstrate the feasibility and efficacy of a minimal invasive approach by using muscle dilator system for treatment lateral lumbar disc herniations.A retrospective analysis 38 cases with herniations that were treated METRx-System was performed. Patients assessed preoperatively postoperatively visual analogue scale (VAS) leg pain. Follow up ranged from 6 24 months.No intraoperative complications observed. Operation time blood loss minimized. In 37 VAS scores significantly...