A5061976592- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Fungal Infections and Studies
- Animal Virus Infections Studies
- Glycosylation and Glycoproteins Research
- Viral gastroenteritis research and epidemiology
- Plant Pathogens and Fungal Diseases
- Light effects on plants
- Escherichia coli research studies
- SARS-CoV-2 and COVID-19 Research
- Antifungal resistance and susceptibility
- CRISPR and Genetic Engineering
- RNA and protein synthesis mechanisms
- Yeasts and Rust Fungi Studies
- Neuroendocrine regulation and behavior
- vaccines and immunoinformatics approaches
- Gut microbiota and health
- interferon and immune responses
- Cytomegalovirus and herpesvirus research
- Vibrio bacteria research studies
University of Utah
2021-2024
Massachusetts Institute of Technology
2016-2024
Howard Hughes Medical Institute
2022-2024
Boston College
2024
Columbia University Irving Medical Center
2017-2018
Animal behavior is directed by the integration of sensory information from internal states and environment. Neuroendocrine regulation diverse behaviors Caenorhabditis elegans under control DAF-7/TGF-β ligand that secreted neurons. Here, we show C. males exhibit an altered, male-specific expression pattern daf-7 in ASJ neuron pair with onset reproductive maturity, which functions to promote mate-searching behavior. Molecular genetic analysis switch-like reveals a hierarchy among multiple...
Sexually dimorphic behaviors are a feature common to species across the animal kingdom, however how such generated from mostly sex-shared nervous systems is not well understood. Building on our previous work which described sexually expression of neuroendocrine ligand, DAF-7, and its role in behavioral decision-making C. elegans (Hilbert Kim, 2017), we show here that sex-specific daf-7 regulated by another Pigment Dispersing Factor (PDF-1), has previously been implicated regulating...
Pathogenic fungi populate a wide range of environments and infect diversity host species. Despite this substantial biological flexibility, the impact interactions between their hosts on evolution pathogenicity remains unclear. We studied how repeated fungus Cryptococcus neoformans relevant environmental mammalian cells-amoeba mouse macrophages-shape model fungal pathogen. First, using collection clinical isolates C. neoformans, we characterized survival phenotypes for these strains when...
Abstract Increasing temperatures associated with climate change have the potential for far-reaching impact on human health and disease vectors, including fungal pathogens. Pathogenic fungi occupy a wide range of environments across world, their ranges been slowly expanding in recent decades due, part, to change. Despite these links between increasing temperature higher prevalence disease, direct effects rising environmental evolution pathogenic remains unclear. In this study, we investigated...
Detection of microbial pathogens is a primary function many mammalian immune proteins. This accomplished through the recognition diverse microbial-produced macromolecules including proteins, nucleic acids, and carbohydrates. Pathogens subvert host defenses by rapidly changing these structures to avoid detection, placing strong selective pressures on proteins that repeatedly adapt remain effective. Signatures rapid evolution have been identified in numerous immunity involved detection...
The molecular mechanisms underlying diversity in animal behavior are not well understood. A major experimental challenge is determining the contribution of genetic variants that affect neuronal gene expression to differences behavioral traits. In Caenorhabditis elegans , neuroendocrine transforming growth factor–β ligand, DAF-7, regulates diverse responses bacterial food and pathogens. dynamic neuron-specific daf-7 modulated by environmental endogenous bacteria-derived cues. Here, we...
Abstract The molecular mechanisms underlying diversity in animal behavior are not well understood. A major experimental challenge is determining the contribution of genetic variants that affect neuronal gene expression to differences behavioral traits. neuroendocrine TGF-beta ligand, DAF-7, regulates diverse responses Caenorhabditis elegans bacterial food and pathogens. dynamic neuron-specific daf-7 modulated by environmental endogenous bacteria-derived cues. Here, we investigated natural...
Abstract Detection of microbial pathogens is a primary function many mammalian immune proteins. This can be accomplished through the recognition diverse microbial-produced macromolecules including proteins, nucleic acids and carbohydrates. Many subvert host defenses by rapidly changing these structures to avoid detection, placing strong selective pressures on proteins that repeatedly adapt remain effective. Signatures rapid evolution have been identified in numerous immunity involved...
Summary Coronaviruses exhibit many mechanisms of genetic innovation, including the acquisition accessory genes that originate by capture cellular or through duplication existing viral genes. Accessory influence host range and tropism, but little is known about how selection acts on these variable regions virus genomes. We used experimental evolution mouse hepatitis (MHV) encoding a AKAP7 phosphodiesterase an inactive native phosphodiesterase, NS2 to model evolutionary fate After courses...
ABSTRACT Sexually dimorphic behaviors are observed in species across the animal kingdom, however relative contributions of sex-specific and sex-shared nervous systems to such not fully understood. Building on our previous work which described sexually expression a neuroendocrine ligand, DAF-7, its role behavioral decision-making C. elegans (Hilbert Kim, 2017), we show here that daf-7 is regulated by another Pigment Dispersing Factor (PDF-1), has previously been implicated regulating...
Abstract Pathogenic fungi populate a wide range of environments and infect diversity host species. Despite this substantial biological flexibility, the impact interactions between their hosts on evolution pathogenicity remains unclear. We studied how repeated fungus Cryptococcus neoformans relevant environmental mammalian cells—amoeba mouse macrophages—shape model fungal pathogen. First, using collection clinical isolates C. , we characterized survival phenotypes for these strains when...