A5049545947- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Analytical Chemistry and Chromatography
- HIV/AIDS drug development and treatment
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical Thermodynamics and Molecular Structure
- Crystal structures of chemical compounds
- Photochromic and Fluorescence Chemistry
- Synthesis of Indole Derivatives
UCLouvain
2019-2020
University of Namur
2016
The crystal structures and optical properties of (E)-2-methoxy-6-(pyridin-3-yliminomethyl)phenol (1), a N-salicylidene-3-aminopyridine, its 2:1 dimorphic cocrystals with fumaric acid (2 3) succinic (4 5) were studied at solid state in order to understand the effects cocrystallization molecular packing on their photo- thermochromic behavior. New criteria for prediction chromic properties, based rationalization intermolecular interaction crystal, are also proposed. These results confirm once...
In this paper, we identified a cocrystal conglomerate of mandelic acid using drug compound as coformer. We then developed chiral resolution process based on preferential cocrystallization. Several versions such were explored and optimized, leading to successful acid, evidencing the efficiency our system. Excellent enantiopurity (98–99%) was obtained with that can run for multiple cycles.
In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three which were obtained with biocompatible cocrystallization agents citric acid, oxalic and zinc chloride. These latter have been fully structurally physically characterized solubility, dissolution rate, stability compared that initial Active Pharmaceutical Ingredient (API).