A5006229839- HER2/EGFR in Cancer Research
- Cell Adhesion Molecules Research
- Cytokine Signaling Pathways and Interactions
- Bone Metabolism and Diseases
- Chronic Kidney Disease and Diabetes
- Rheumatoid Arthritis Research and Therapies
- Mesenchymal stem cell research
- Academic Writing and Publishing
- AI in cancer detection
- Xenotransplantation and immune response
- Wnt/β-catenin signaling in development and cancer
- Spondyloarthritis Studies and Treatments
- Pluripotent Stem Cells Research
- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- SARS-CoV-2 and COVID-19 Research
- Folate and B Vitamins Research
- Biomedical Research and Pathophysiology
- Parathyroid Disorders and Treatments
- Advanced Glycation End Products research
- Oral Health Pathology and Treatment
- Cancer Genomics and Diagnostics
- Genetic Associations and Epidemiology
- Osteoarthritis Treatment and Mechanisms
Alikhan Bokeikhan University
2024
Nazarbayev University
2018-2024
Astana Medical University
2016
ABSTRACT Proteinuria is a well-established biomarker of chronic kidney disease (CKD) and risk predictor associated outcomes. also driver CKD progression toward end-stage disease. Toxic effects filtered proteins on proximal tubular epithelial cells enhance atrophy interstitial fibrosis. The extent protein toxicity the underlying molecular mechanisms responsible for injury during proteinuria remain unclear. Nevertheless, albumin elicits its toxic when degraded reabsorbed by cells. Overall,...
The formation of destructive hypercellular pannus is critical to joint damage in rheumatoid arthritis (RA). collagen triple helix repeat containing 1 (CTHRC1) protein expressed by activated stromal cells diverse origin has previously been implicated tissue remodeling and carcinogenesis. We recently discovered that the synovial Cthrc1 mRNA directly correlates with severity mice. This study characterizes role CTHRC1 arthritic formation.
Background. The purpose of this study was to determine whether plasma levels the collagen triple helix repeat containing 1 (CTHRC1) protein can serve as a blood-based biomarker for improved diagnosis rheumatoid arthritis (RA) patients and monitoring RA disease activity. Methods. We measured CTHRC1 in diagnosed with RA, osteoarthritis (OA), reactive (ReA), well healthy individuals. then assessed correlation between range indices including 28-joint activity score (DAS28), factor (RF),...
Over the past 10 years, developments in precision oncology have led to a rise demand for predictive tools that assist screening and stratification of patients treatment. The possibility digitizing tissue slide images has creation artificial intelligence (AI) machine learning algorithms digital pathology, which could ultimately improve patient care. In this context, we assessed variety AI-based computational models pathology. review, described latest AI applications oncology, current...
Background: Chronic kidney disease (CKD) has various etiologies, making it impossible to fully understand its complex pathophysiology. Elevated levels of plasma creatinine, proteinuria, and albuminuria declined eGFR are traits observed in CKD patients. The current study attempts highlight the collagen triple helix repeat containing 1 (CTHRC1) protein as a putative blood biomarker for addition existing recognized indicators progression. Methods: A total 26 patients 18 healthy controls were...
Rheumatoid arthritis (RA) is a chronic autoimmune disease, causing inflammation of joints, cartilage destruction and bone erosion. Biomarkers new drug targets are actively sought progressed to improve available options for patient treatment. The Collagen Triple Helix Repeat Containing 1 protein (CTHRC1) may have an important role as biomarker rheumatoid arthritis, CTHRC1 concentration significantly elevated in the peripheral blood patients, compared osteoarthritis (OA) patients healthy...
Background: Monoclonal antibody (mAb) therapy is a promising antiviral intervention for Coronovirus disease (COVID-19) with potential both treatment and prophylaxis. However, major barrier to implementing mAb therapies in clinical practice the intricate nature of preparation delivery. Therefore, here, pre-clinical model, we explored possibility severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) delivery using mAb-expressing encapsulated cell system. Methods: Murine G-8 myoblasts...
Coronary artery disease (CAD) is one of the leading diseases contributing to mortality. Although it has a hereditary nature, its genetic etiology remains unclear. Recently, many studies showed risk factors using genome-wide association studies, and gene variant with CAD. Despite recent breakthroughs on various single nucleotide polymorphisms (SNP) linked CAD, encompassing genes affecting metabolic disorders, influencing endothelial smooth muscle dysfunctions, plaque formation myocardial...
Introduction: Autologous bone marrow stem cell transplantation (ABMT) is one of the promising treatment options in diabetes mellitus (DM). In 2010s, Ministry Healthcare Republic Kazakhstan (MOH) approved a protocol with ABMT DM single tertiary hospital. However, there limited data about long-term all-cause mortality and diabetes-related complications after compared to conventional (CT). We aimed study patients who underwent versus using large-scale administrative health from Unified National...