A5112910163- Antibiotics Pharmacokinetics and Efficacy
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Epigenetics and DNA Methylation
- Prenatal Screening and Diagnostics
- Acupuncture Treatment Research Studies
- Endometrial and Cervical Cancer Treatments
- Protease and Inhibitor Mechanisms
- Neurological Disease Mechanisms and Treatments
- Brucella: diagnosis, epidemiology, treatment
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Peroxisome Proliferator-Activated Receptors
- Immune Cell Function and Interaction
- Pluripotent Stem Cells Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Machine Learning in Bioinformatics
University of Washington
2025
Brotman Baty Institute
2025
Second Xiangya Hospital of Central South University
2022-2023
Central South University
2022-2023
Third Xiangya Hospital
2022
Shihezi University
2019
First Affiliated Hospital of Sichuan Medical University
2011
Southwest Medical University
2011
Baylor College of Medicine
1990
Polymyxin B is the first-line therapy for Carbapenem-resistant organism (CRO) nosocomial pneumonia. However, clinical data its pharmacokinetic/pharmacodynamic (PK/PD) relationship are limited. This study aimed to investigate between polymyxin exposure and efficacy treatment of CRO pneumonia in critically ill patients, optimize individual dosing regimens.Patients treated with were enrolled. Blood samples assayed using a validated high-performance liquid chromatography-tandem mass spectrometry...
Twenty-three of the 25 cysteine residues in apolipoprotein B-100 have been isolated directly from tryptic or peptic peptide mixtures. Sixteen exist disulfide forms: Cys-1-Cys-3, Cys-2-Cys-4, Cys-5-Cys-6, Cys-7-Cys-8, Cys-9-Cys-10, Cys-11-Cys-12, Cys-13-Cys-14, and Cys-20-Cys-21. All these except Cys-20-Cys-21 are recently discovered linkages. In addition to Cys-22 Cys-24, which described as sulfhydryls on low density lipoprotein, Cys-15 Cys-18 Cys-23 reduced form. Cys-19 Cys-25 not yet...
Abstract Aneuploidy in embryos poses a major barrier to successful human reproduction, contributing nearly 50% of early miscarriages. Despite its high prevalence embryos, the molecular mechanisms regulating aneuploid cell fate during development remain poorly understood. This knowledge gap persists due ethical constraints embryo research and limitations existing animal models. In this study, we identified New World primate marmoset (Callithrix jacchus) as suitable model for investigating...
Clinically, xenotransplantation often leads to T-cell-mediated graft rejection. Immunosuppressive agents including polyclonal regulatory T cells (poly-Tregs) promote global immunosuppression, resulting in serious infections and malignancies patients. Xenoantigen-expanded Tregs (xeno-Tregs) have become a promising immune therapy strategy protect xenografts with fewer side effects. In this study, we aimed identify an efficient stable subset of xeno-Tregs. We enriched CD27 + xeno-Tregs using...
Background. Epigenetic mechanism plays an important role in endometrial carcinoma (EC). This study was designed to analyze the epigenetic between DNA methylation-driven genes (DEDGs) and drugs targeting DEDGs develop a DEDG score model for predicting prognosis of EC. Methods. Expression profile methylation data PD-1-negative EC samples were obtained from TCGA. To obtain intersected DEDGs, differentially expressed (DEGs) methylated tumor tissues normal analyzed by limma. A linear discriminant...
Objective To study the expression of microtubule-associated protein-2 (MAP-2) in CA3 region hippocampus and any effect acupuncture combined with exercise training on recovery learning memory after experimental cerebral infarction.Methods Eighty Wistar rats were randomly divided into a sham-operation group (n = 8 ) an operation 72 subdivided equally model group, exercisetraining plus 24 each group. After right middle artery occlusion or mock operation, MAP-2 was detected immunohistochemistry...
This work was carried out to analyze of effects twelve microsatellite loci and genetic heterozygosity on wool fineness natural length, which are important indicators for evaluating quality.131 individuals from F2 F3 generations Australian Merino Chinese sheep (Xinjiang military reclamation type) mating were used as experimental subjects.Five chromosome 1 seven 6 determined related with length wool.The results showed that 3 significantly associated fiber diameter (WFD), 4 (WNL).WFD increased...
Abstract Background Polymyxin B is the first line therapy for Carbapenem-resistant organism (CRO) nosocomial pneumonia. However, clinical data its pharmacokinetic/pharmacodynamic (PK/PD) relationship limited. This study aimed to investigate between polymyxin exposure and efficacy treatment of CRO pneumonia in critically ill patients, optimize individual dosing regimens. Methods Patients treated with were enrolled. Blood samples assayed using a validated high-performance liquid...