A5043469838- DNA Repair Mechanisms
- Fungal and yeast genetics research
- Genomics and Chromatin Dynamics
- Cancer therapeutics and mechanisms
- Plant Gene Expression Analysis
- Chromosomal and Genetic Variations
- Developmental Biology and Gene Regulation
- Pluripotent Stem Cells Research
- Fermentation and Sensory Analysis
- Photosynthetic Processes and Mechanisms
- Education Methods and Technologies
- CRISPR and Genetic Engineering
- Sociology and Education Studies
- Microtubule and mitosis dynamics
- German legal, social, and political studies
Körber (Germany)
2017-2023
Karolinska Institutet
2010-2017
Stockholm University
2002-2006
Umeå University
2000-2001
Illegitimate recombination (IR) is the process by which two DNA molecules not sharing homology to each other are joined. In Kluyveromyces lactis, integration of heterologous occurred very frequently therefore constituting an excellent model organism study IR. IR was completely dependent on nonhomologous end-joining (NHEJ) pathway for double strand break (DSB) repair and we detected no pathways capable mediating NHEJ versatile, repairing both blunt non-complementary ends efficiently. Mapping...
Abstract In Saccharomyces cerevisiae, transcriptional silencing of the cryptic mating type loci requires formation a heterochromatin-like structure, which is dependent on silent information regulator (Sir) proteins and DNA sequences, called silencers. To learn more about silencing, we characterized from yeast Kluyveromyces lactis. The K. lactis MAT, HMRa, HMLα shared flanking sequences both sides presumably acting as recombinational targets during switching. HMRa contained two genes, a1 gene...
ABSTRACT We studied the silencing of cryptic mating-type loci HML α and HMR a in budding yeast Kluyveromyces lactis . A 102-bp minimal silencer fragment was defined that both necessary sufficient for α. Mutagenesis revealed three distinct regions (A, B, C) were important silencing. Recombinant K. ribosomal DNA enhancer binding protein 1 (Reb1p) could bind vitro, point mutations B box abolished Reb1p function. Furthermore, strains carrying temperature-sensitive alleles REB1 gene derepressed...
ABSTRACT Mutations in structural maintenance of chromosomes (Smc) proteins are frequently associated with chromosomal abnormalities commonly observed developmental disorders. However, the role Smc development still remains elusive. To investigate Smc5/6 function during early embryogenesis we examined smc5 and smc6 mutants fruit fly Drosophila melanogaster using a combination reverse genetics microscopy approaches. exhibited maternally contributed maintaining chromosome stability embryo...
Gesellschaft ist durch neue Subjektivierungsformen im Wandel begriffen. Die erzeugte Optionsvielfalt und Widersprüchlichkeit fordern das Subjekt heraus. Es könnte mithilfe einer demokratiedidaktischen Diskursreflexivität Orientierung erhalten, die eine Verknüpfung der Begriffe âDiskursâ âReflexivitätâ bestimmt werden soll. Dadurch soll zunehmend fähig sein, Wirkung des Diskurses auf sich seine Möglichkeit, den Diskurs mitzugestalten, besser verstehen zu können.
The structural maintenance of chromosomes 5/6 (Smc5/6) complex controls recombination in response to replicative stress, within the ribosomal DNA, and at telomeres. It has also been suggested act parallel with topoisomerase 1 (Top1) resolution replication-induced superhelical stress under unperturbed conditions. In addition this, human Smc5/6 was recently shown suppress expression genes present on episomal DNA. here presented study aimed investigate function transcriptionally silenced,...
Der âDidaktische Politikbegriffâ könnte über didaktische Prinzipien eine deduktive Unterrichtsplanung und einen induktivenLernprozess ermöglichen. Darin liegt das Ziel, durch die verschiedenen Konzepte Begriffe des âDidaktischen PolitikbegriffsâMöglichkeiten zum Transferlernen aufzuzeigen â unter Berücksichtigung der Didaktiken Politik, Geographieund Wirtschaftskunde. Die theoretischen Ãberlegungen werden um ein Praxisbeispiel ergänzt, zu zeigen, wie Planungsmodellfür den...