The aim of the study was to investigate relationship between serum zonulin and cellular immunity in patients with ulcerative colitis (UC) Crohn’s disease (CD). included 97 patients, 13 (13.4%) CD 84 (86.6%) UC. concentration studied using ELISA kits. investigation circulated leukocyte subpopulation carried out through flow cytometry. functional activity circulating neutrophils absorption capacity monodisperse polystyrene latex particles indicators oxygen-dependent metabolism nitroblue...

Neutrophils expressing vascular endothelial growth factor receptor (VEGFR) represent a distinct subtype of neutrophils with proangiogenic properties. The purpose this study was to identify the interrelations between circulating CD16hiCD11bhiCD62LloCXCR2hiVEGFR2hi-neutrophils and indicators carotid plaque burden in patients without atherosclerotic cardiovascular diseases (ASCVD).The included 145 patients, 51.7% men 48.3% women, median age-49.0 years. All underwent duplex ultrasound scanning....

To study the features of atherosclerosis peripheral arteries in patients with coronary artery disease (CAD) depending on presence type 2 diabetes mellitus (T2DM) and to identify factors associated multifocal atherosclerosis.The included 140 (77 men 63 women) CAD (mean age 62.0 (56.0-66.0) years). The first group 70 people T2DM, second without T2DM. All underwent duplex scanning carotid lower limb (LLA). Local vascular stiffness common (CCA) was assessed by ultrasound scanning. Peterson...

Background: The use of ultrasound-based methods for imaging subclinical atherosclerosis, including measurement carotid plaque burden (cPB), is a promising direction further improvement major adverse cardiac and cerebrovascular events (MACCE) prediction. Objectives: aim the study was to research prognostic values’ significance cPB indicators with regard short-term progression polyvascular atherosclerosis long-term onset MACCE. Design: Single-center prospective cohort study. Methods: included...

to identify the differences between serum cytokine profiles in juvenile idiopathic arthritis (JIA) with or without uveal tract inflammation.Serum were studied two groups of patients: 20 children JIA and JIA-associated uveitis 33 children, who had no signs under basic therapy for their JIA. All patients showed drug remission articular syndrome. Inflammation choroid took form chronic anterior uveitis. The process was active 95% cases. control group consisted 35 rheumatic disease other acute...

BACKGROUND: The study of low-grade inflammation in patients with type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular diseases is a pressing problem. A deeper understanding the cascade inflammatory reactions, possibly mediating severe lesions various vascular pools diabetes, has potential to introduce more sophisticated diagnostic therapeutic approaches into practice. AIM: To interrelation atherosclerosis peripheral arteries coronary artery disease (CAD) T2DM. MATERIALS AND...

Aim. Study effects of microwave electromagnetic radiation (EMR) the SHF range in vitro on viability and functional status neutrophilic granulocytes. Materials methods. Neutrophils peripheral blood 30 conditionally healthy donors aged 18 - 20 years were exposed to effect broadband (natural, similar sun radio emission) mono-frequency (technogenic, emission cell phones, PCs, ovens, etc.) EMR with frequency 4 4.34 GHz, generated by a SHF-generator «А1МТ-1». 16 minutes after effect, granulocytes,...

Current data on the possible involvement of aging neutrophils in atherogenesis are limited. This study aimed to research diagnostic value their relation subclinical atherosclerosis statin-naïve patients without established atherosclerotic cardiovascular diseases (ASCVD). The was carried out 151 aged 40-64 years old ASCVD. All underwent duplex scanning carotid arteries, lower limb arteries and abdominal aorta. Phenotyping differentiation neutrophil subpopulations were performed through flow...

The paper presents results of studying systemic and local level cytokines in retinal vein occlusion following antiangiogenic therapy. study cytokine concentrations was conducted the general group patients, depended on type before after intravitreal injections Ranibizumab. We examined thirty-two patients with occlusion. performed standard ophthalmological examinations, spectral optical coherence tomography, fluorescent angiography order to establish determined concentration vascular...

Aim . To evaluate the diagnostic and prognostic value of circulating mature aging neutrophils in relation to hypoechoic carotid plaques short-term progression multifocal atherosclerosis. Material methods The study included 200 patients (89 males 111 fe­males), aged 40-64 years. All underwent duplex ultrasound lower extremity arteries at first visit a repeat after 12-24 months. Ultrasound morphology was assessed using greyscale median analysis. Phenotyping differentiation neutrophil...

The basis of the pathogenesis immunologic male infertility is production antisperm antibodies against sperm antigens by plasmocytes. Extracellular nucleic acids, among other antigens, are perceived as DAMPs. clearance system for biological fluids complex. Endonucleases responsible utilization extracellular DNA. Among endonucleases, DNase 1 most studied. Its concentration in higher than others. For first time, we determined seminal fluid men reproductive age. values were compared with level...

Aim of this study was to determine the characteristics laboratory parameters hemostasis, carbohydrate and lipid metabolism in women with metabolic syndrome, isolated abdominal obesity or hypertension.Materials methods. The included 71 aged 30 – 44 years conducted at hemostasis system, metabolism.Results. In arterial hypertension we found an increased levels glucose, total cholesterol, LDL-C triglycerides a decrease concentration HDL-C compared healthy women. revealed prothrombotic changes...

Aim. To evaluate the clinical and endoscopic features of diseases upper gastrointestinal tract (GIT) in patients with atherosclerosis mesenteric arteries (MA). Materials methods. The study included 48 MA 43 without MA, who were hospitalized department vascular surgery Chelyabinsk Regional Clinical Hospital period from 2019 to 2021. All underwent multispiral computed tomoangiography visceral lower limb arteries, esophagogastroduodenoscopy. Results. Assessment lesions revealed a higher...

INTRODUCTION: Noninvasive assessment of carotid atherosclerotic plaque (CAP) morphology represents a promising direction, allowing to optimize not only cardiovascular event risk assessment, but also the selection patients for revascularization. Determination CAP echogenicity by means GSM-analysis can be used as part multiparametric instability and prediction adverse events. OBJECTIVE: To assess predictive value plaques in relation development events 40–64 years old. MATERIALS AND METHODS :...

Objective. The objective was to study the relationship between psychological and emotional features, hormonal changes left ventricular hypertrophy (LVH) in subjects with normal blood pressure (BP). Design methods. included 107 practically healthy people of working age from an organized population, including 46 men (mean 43,7 ± 11,5 years) 61 women 43,1 10,1 years). In all subjects, fasting samples for hormone level evaluation were taken, structural myocardial assessed by echocardiography, BP...

This was a prospective study in group of 130 pregnant women. The main (group I) included 100 women with history chronical endometritis, the control II) – 30 physiological pregnancy and no obstetrical gynecological disorders. Pregnant I were divided into two subgroups. subgroup IA includes 75 patiens which ended time condition newborns fine. IB are unsuccessful (premature birth, neonatal infection, perinatal death). As result research noted activation mechanisms congenital immunity...

External genital endometriosis is an inflammatory, estrogen-dependent disease that develops predominantly in women of reproductive age and characterized by the presence pain syndrome infertility. Today, one most common gynecological diseases age, however, etiology pathogenesis it are not completely clear. Violations systemic immunity important endometriosis. The literature data on features immune response combination with infection few contradictory. Purpose – to study external pathogens...

Introduction . External manifestations of aging, and especially skin aging are the most important for modern women. Aim The aim our study was to identify a set adverse factors that effect on women in menopausal transition (MP) postmenopause (PM), markers this category Materials methods included 36 MP PM suffering from MS. At first stage, anamnesis collected, anthropometric data severity MS were evaluated, hormonal profile patients determined. second computer mapping performed using digital...

The last fifteen years have been marked by rapid progress in the study of neutrophils. discovery transcriptional plasticity neutrophils, their phenotypic and functional heterogeneity contributed to launching active interdisciplinary studies on role neutrophils various chronic inflammatory diseases. Increased systemic circulation immunosuppressive can be observed not only sepsis, but also inflammation, which, along with disorders lipid metabolism, is major mechanism atherosclerosis...

It has been established that an increase in triglyceride-rich lipoprotein levels is associated with the development of systemic low-grade inflammation. Data on prognostic role hypertriglyceridemia (HTG) dependent state inflammation are limited.The study's objective was to evaluate predictive value mild-to-moderate HTG (2.3- 11.2 mmol/L) regarding cardiovascular events patients at high and very risk (CVR), depending high-sensitivity C-reactive protein (hsCRP) values.The study included 185...

Rationale. In the context of optimizing preoperative treatment chronic suppurative otitis media (CSOM), it is important to study changes in biochemical markers inflammation middle ear justify appointment anti-inflammatory therapy prevent complications postoperative period surgery. Objective. To level indicators inflammatory metabolism and increase effectiveness pharmacotherapy patients with CSOM by using drug ammonium glycyrrhizinate. Patients methods. The prospective involved 48 diagnosed...

At the present time, sepsis is primarily considered a disorder of immune system caused by dominant infection, manifesting with individual response reaction host organism. Hence, should not be classified as distinct pro- or anti-inflammatory syndrome, but rather variable continuum overlapping mechanisms. The role innate immunity in probably leading one, since it exerts an early and nonspecific to any foreign agent. nature appropriate relationships may determine current state system. To...