A5057204082- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Click Chemistry and Applications
- Cancer-related Molecular Pathways
- Synthesis and Reactions of Organic Compounds
- Bioactive Compounds and Antitumor Agents
- Ubiquitin and proteasome pathways
- Synthesis of heterocyclic compounds
- Protein Degradation and Inhibitors
- Chemical Synthesis and Analysis
- Cancer, Hypoxia, and Metabolism
- Microtubule and mitosis dynamics
- Synthesis and Catalytic Reactions
- CRISPR and Genetic Engineering
- Phytochemistry and Biological Activities
- Synthesis of Tetrazole Derivatives
- Genomics and Chromatin Dynamics
- Radical Photochemical Reactions
- Catalytic C–H Functionalization Methods
- Synthesis and Characterization of Heterocyclic Compounds
- Molecular spectroscopy and chirality
- Fluorine in Organic Chemistry
- Natural product bioactivities and synthesis
University of Denver
2018-2024
Lomonosov Moscow State University
2015-2023
Abstract The YEATS domain has been identified as a reader of histone acylation and more recently emerged promising anti-cancer therapeutic target. Here, we detail the structural mechanisms for π-π-π stacking involving domains yeast Taf14 human AF9 acylated H3 peptides explore DNA-binding activities these domains. Taf14-YEATS selects crotonyllysine, forming π with both crotonyl amide alkene moiety, whereas AF9-YEATS exhibits comparable affinities to saturated unsaturated acyllysines, engaging...
NMR data for natural products containing the epoxy moiety have been revisited and reanalyzed with help of a recently developed parametric/DFT hybrid computational method, DU8+. More than 20 structures needed revision, which points to challenges in solution structure assignment molecules possessing this structural feature. Among revised are achicretin 2, acremine P, aromaticane I, artanomalide B, botryosphaerihydrofuran, chloroklotzchin, crithmifolide, crotodichogamoin A, emervaridone C,...
Novel variously substituted thiohydantoin-based dispiro-indolinones were prepared using a regio- and diastereoselective synthetic route from 5-arylidene-2-thiohydantoins, isatines, sarcosine. The obtained molecules subsequently evaluated in vitro against the cancer cell lines LNCaP, PC3, HCTwt, HCT(-/-). Several compounds demonstrated relatively high cytotoxic activity vs. LNCaP cells (IC50 = 1.2-3.5 µM) reasonable selectivity index (SI 3-10). Confocal microscopy revealed that conjugate of...
Photoinduced cascade of two 6π-electron six- and five-center electrocyclizations in aromatic azido imines is oxidatively controlled to yield complex fused benzimidazoles or indazoles. Formation occurs via an unprecedented carbon-to-nitrogen