A5055591760- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Computational Drug Discovery Methods
- Synthetic Organic Chemistry Methods
- Microbial Natural Products and Biosynthesis
- Machine Learning in Materials Science
- Carbohydrate Chemistry and Synthesis
- Analytical Chemistry and Chromatography
- Inorganic Fluorides and Related Compounds
- Asymmetric Synthesis and Catalysis
- Catalytic Alkyne Reactions
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Analysis
- Fluorine in Organic Chemistry
- Clay minerals and soil interactions
- Oxidative Organic Chemistry Reactions
- Click Chemistry and Applications
- Various Chemistry Research Topics
- Asymmetric Hydrogenation and Catalysis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Chemistry and Chemical Engineering
- Magnesium Oxide Properties and Applications
University of Utah
2023-2024
University of California, Berkeley
2019-2023
Institut National des Sciences Appliquées Rouen Normandie
2019
Centre National de la Recherche Scientifique
2019
Université de Rouen Normandie
2019
Laboratoire COBRA
2019
Normandie Université
2019
University of Minnesota
2018
Catalytic enantioselective methods that are generally applicable to a broad range of substrates rare. We report strategy for the oxidative desymmetrization
Abstract Methods to introduce fluorine atoms or fluoroalkyl groups are highly valuable the design and development of biologically active compounds. To date, majority fluorinated pharmaceuticals agrochemicals bear a atom CF 3 group at non‐stereogenic center. The methods for construction new, emerging motifs, in particular those combining heteroatom fluorocarbon moiety have witnessed tremendous advancement recent years; however, challenging problem is stereocontrol carbon center featuring such...
The SARS-CoV-2 pandemic has prompted scientists from many disciplines to work collaboratively toward an effective response. As academic synthetic chemists, we examine how best contribute this ongoing effort.
One major goal of organometallic chemists is the direct functionalization bonds most recurrent in organic molecules: C–H, C–C, C–O, and C–N. An even grander challenge C–C bond formation when both precursors are this category. Parallel to synthetic achieving reaction selectivity that contrasts with conventional methods. Electrophilic aromatic substitution (EAS) via Friedel–Crafts acylation renowned method for synthesis aryl ketones, a common structural motif many pharmaceuticals,...
A first-of-its-kind enantioselective aromatic Finkelstein reaction is disclosed for the remote desymmetrization of diarylmethanes. The operates through a copper-catalyzed C-I bond-forming event, and high levels enantioselectivity are achieved deployment tailored guanidinylated peptide ligand. Strategic use transition-metal-mediated reactions enables chemoselective modification aryl iodide products; thus, synthesis diverse set otherwise difficult-to-access diarylmethanes with excellent...
Data-driven reaction discovery and development is a growing field that relies on the use of molecular descriptors to capture key information about substrates, ligands, targets. Broad adaptation this strategy hindered by associated computational cost descriptor calculation, especially when considering conformational flexibility. Descriptor libraries can be pre-computed agnostic application reduce burden data-driven development. However, as one often applies these models evaluate novel...
The synthesis of aryl amines from 3-alkynyl-2-pyrones and various is described. Mechanistically, the are proposed to arise 3-alkynyl-2-pyrone substrates through their selective opening in a 1,6-fashion by secondary followed decarboxylation an unexpected rearrangement. mechanism supported quantum chemical transition-state calculations, which consistent with regiochemical outcome. scope this transformation spans variety range amines. influence amine coupling partners on reaction efficiency was...
Data-driven reaction discovery and development is a growing field that relies on the use of molecular descriptors to capture key information about substrates, ligands, targets. Broad adaptation this strategy hindered by associated computational cost descriptor calculation, especially when considering conformational flexibility. Descriptor libraries can be precomputed agnostic application reduce burden data-driven development. However, as one often applies these models evaluate novel...
Herein, we describe our synthetic efforts toward the pupukeanane natural products, in which have completed first enantiospecific route to 2-isocyanoallopupukeanane 10 steps (formal synthesis), enabled by a key Pd-mediated cyclization cascade. This subsequently facilitated an unprecedented bio-inspired "contra-biosynthetic" rearrangement, providing divergent access 9-isocyanopupukeanane 15 synthesis). Computational studies provide insight into nature of this rearrangement.
Abstract A Pd‐catalyzed heterocyclization/carbonylation/arylation cascade reaction between β,γ‐unsaturated N−Ts hydrazones and commercially available arylboronic acids as coupling partners is described, producing 2‐pyrazoline‐ketone derivatives in 11–78% yield. detailed statistical analysis of reactivity patterns boronic provided key information about the limitations method, highlighting challenges degradation pathways. Our methodology offers a tool for synthesizing diverse derivatives,...
Abstract Herein, we describe our synthetic efforts toward the pupukeanane natural products, in which have completed first enantiospecific route to 2‐isocyanoallopupukeanane 10 steps (formal synthesis), enabled by a key Pd‐mediated cyclization cascade. This subsequently facilitated an unprecedented bio‐inspired “contra‐biosynthetic” rearrangement, providing divergent access 9‐isocyanopupukeanane 15 synthesis). Computational studies provide insight into nature of this rearrangement.