A5064297922- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Memory and Neural Mechanisms
Northwestern University
2017
Royal Netherlands Academy of Arts and Sciences
2017
Netherlands Institute for Neuroscience
2017
Excitatory synaptic transmission is mediated by AMPA-type glutamate receptors (AMPARs). In CA1 pyramidal neurons of the hippocampus two types AMPARs predominate: those that contain subunits GluA1 and GluA2 (GluA1/2), GluA3 (GluA2/3). Whereas have been extensively studied, contribution to synapse physiology has remained unclear. Here we show in mice GluA2/3s are a low-conductance state under basal conditions, although present at synapses they contribute little currents. When intracellular...