A5001024908- Platelet Disorders and Treatments
- Blood groups and transfusion
- Immunodeficiency and Autoimmune Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Hemophilia Treatment and Research
- Blood properties and coagulation
- COVID-19 Clinical Research Studies
- Chronic Lymphocytic Leukemia Research
- Child Nutrition and Water Access
- Blood disorders and treatments
- Blood Coagulation and Thrombosis Mechanisms
- Child Nutrition and Feeding Issues
- Infant Nutrition and Health
- Carbohydrate Chemistry and Synthesis
- Trypanosoma species research and implications
- Infant Development and Preterm Care
- Venous Thromboembolism Diagnosis and Management
- Eosinophilic Esophagitis
- Growth Hormone and Insulin-like Growth Factors
- Lysosomal Storage Disorders Research
- Genetics and Neurodevelopmental Disorders
- Stroke Rehabilitation and Recovery
- Physical Activity and Health
- Cancer-related gene regulation
- Infant Health and Development
University of Bari Aldo Moro
2018-2024
Ospedale Pediatrico Giovanni XXIII
2018-2022
Associazione Italiana Ematologia Oncologia Pediatrica
2018
Background: the thrombopoietin receptor agonist eltrombopag has been shown to be safe and effective for children with chronic immune thrombocytopenia (ITP). The aim of present study was characterize use in current clinical practice. Material methods: This is a retrospective multicentre conducted 17 centres affiliated Italian Association Pediatric Haematology Oncology (AIEOP). primary objective determine prevalence affected by ITP, after EMA authorization pediatric age. secondary assess...
Abstract Background In GM1 gangliosidosis the lack of function β‐galactosidase results in an accumulation ganglioside and related glycoconjugates visceral organs, particularly central nervous system, leading to severe disability premature death. type 2 form disease, early intervention would be important avoid precocious complications. To date, there are no effective therapeutic options preventing progressive neurological deterioration. Substrate reduction therapy with Miglustat, a...
Objectives—Failure to thrive (FTT) in infants is characterized by growth failure. Although, cow’s milk allergy (CMA) may have an impact on and leads FTT, data are still limited. We focused FTT as a possible clinical marker for early diagnosis of CMA. The aim the present study was evaluate implications hypersensitivity with catch-up after milk-free diet (CMFD). Methods—A cross-sectional all consecutive evaluated at Pediatric Nutrition Allergy Unit University Hospital Bari (Italy) from January...
Letter to Editor
BACKGROUND Preterm neonates are likely to require red blood cell (RBC) transfusion, and extremely low birth weight infants almost invariably receive multiple transfusions. Transfusion-reduction strategies can reduce transfusion rates, might diminish certain adverse outcomes associated with MATERIALS AND METHODS In a single centre, we retrospectively evaluated RBC rates among preterm ≤32 weeks' gestational age (GA), over 6-year period before after adopting national transfusion-reduction...
Fatigue is an important clinical and psychological aspect for a significant number of children affected by immune thrombocytopenia (ITP). To date, few studies have explored fatigue its relationship with chronic ITP in pediatric age. The aim the present multicentric pilot study to determine perception large group their caregivers using PedsQL Multidimensional Scale (PedsQL MFS), compare results those healthy control subjects.Children aged 5-18 years and/or 2-18 were enrolled. Child/adolescent...
Immunoglobulin G (IgG) replacement therapy is a standard treatment for patients with primary immunodeficiency diseases (PIDs). Hizentra®, 20% human subcutaneous IgG (SCIG), approved biweekly administration PIDs. The aim of the multicenter IBIS study was to prospectively investigate efficacy Hizentra® compared previous IVIG or SCIG regimens in consisted 12-month retrospective period followed by prospective observational period. main endpoints included pre-infusion concentrations, proportion...
Objective: Primary immune thrombocytopenia (ITP) is a hemorragic disorder. Spontaneous recovery within 6 months occurs in the majority of pediatric patients. Nevertheless, 20–30% children disease chronic. The impact extends to patients' families, whose everyday life, terms interpersonal relationships and financial status, adversely affected. This study investigated ability narrative instrument improve quality life chronic ITP patients their families quantified familial burden imposed by...
Allowing children to participate in extracurricular activities, such as sports, helps them explore and develop skills which are considered beneficial throughout their lives. By participating exposed various mental, social, emotional, physical, educational benefits. The physical benefits of sports participation obvious: it reduces the risk obesity, improves cardiovascular performance, strengthens osteoarticular system, stabilizes sleep-wake biorhythm. psychological no less important: develops...
Immune thrombocytopenia (ITP) is an acquired immuno-mediated disorder characterized by with increased risk of bleeding. In recent years 1,25[OH]2D3 has been rediscovered as immune modulator. We decided to evaluate serum Vitamin D levels in a cohort children order discover if concentrations may predict ITP duration.Thirty were enrolled this study (sixteen chronic and fourteen newly diagnosed ITP) assess levels.The results showed that 80% the presented hypovitaminosis status. Children...
Inherited thrombocytopenias (ITs) are rare congenital bleeding disorders characterized by different clinical expression and variable prognosis. ITs poorly known clinicians often misdiagnosed with most common forms of thrombocytopenia."CHildren Platelet Surveillance" study (CHIPS) is a retrospective - prospective observational cohort conducted between January 2003 2022 in 17 centers affiliated to the Italian Association Pediatric Hematology Oncology (AIEOP). The primary objective this was...
Immune thrombocytopenia (ITP) is a common bleeding disorder in childhood. The management of ITP children controversial, requiring personalized assessment patients and therapeutic choices. Thrombopoietin receptor agonists (TPO-RAs), eltrombopag romiplostim, have been shown to be safe effective for the treatment pediatric ITP. aim our research define role thrombopoietin ITP.This review focuses on use TPO-RAs ITP, randomized trials clinical routine, highlighting their key disease.Eltrombopag...
BACKGROUND AND AIM OF THE WORK Sport participation, regular exercise and physical activity in general exert many benefits on wellness, perceived health related quality of life social satisfaction. As the people age, mental deterioration occur. Master athletes are older adults that practice different sports, such as running, swimming badminton. This is a widespread sport practiced by over 200 million one most exerted world. In our study we compared perception Italian Badminton normal...
Inherited thrombocytopenias represents a heterogenous group of diseases characterized by congenital reduction in the platelet count that could lead to bleeding tendency. MYH9-related disorders are large platelets and thrombocytopenia. Thrombopoietin-receptor agonists: eltrombopag romiplostim currently approved many countries for treatment different forms acquired thrombocytopenia, such as immune We report, instead, successful use treat inherited thrombocytopenia patient with an MHY9-related...
Abstract Background Hemophilia B is a rare bleeding disorder in males, characterized by deficiency coagulation factor IX (FIX). Replacement of FIX with recombinant (rFIX) fusion protein, to sustain therapeutic plasma levels, recommended as both treatment and prophylaxis prevent episodes, particularly intracranial hemorrhage (ICH). Case presentation This case report outlines the management ICH 7-month-old infant severe hemophilia B, following an accidental trauma-related event, resulting thin...
Hemophilias are hemorrhagic congenital rare diseases. The gold standard of therapy in hemophilics is the intravenously replacement therapy. We can infuse plasma derived factors (FVIII for Hemophilia A and FIX B) or recombinant products (i.e. clotting factor synthetically produced). Venipuncture not a safe procedure subjects with It considered an invasive technique potential massive bleeding it requires standardized procedures to prevent complications. Local pressure after (with eventually...
Background: Subcutaneous immunoglobulin G (SCIG) may be a better option than intravenous (IVIG) for patients with primary immunodeficiencies (PID) due to reduced systemic and serious adverse reactions easier administration. The Infusione Bimensile di Immunoglobuline Sottocute (IBIS) study investigated the effects of Hizentra®, 20%-concentrated SCIG, administered biweekly in PID. This subanalysis aimed evaluate clinical laboratory outcomes IBIS pediatric subcohort. Methods: Thirteen children...
Background ad aim of workː the position Italian law regarding participation prophylactically treated hemophiliacs to organized sport trainings and competitions remains unclear this study focuses on eligibility pediatric patients in particular. Methodsː 16 age 3 15 years old, with severe haemophilia prophylaxis starting 20,2 ± 2,2 months were enrolled. Weight, height, body mass index (BMI) joint status (Hemophilia Joint Health Score [HJHS] Haemophilia Early Arthropathy Detection UltraSound,...
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia. Many viruses and some vaccines have been identified as triggering the process, including parvovirus, human immunodeficiency virus, Epstein-Barr rubella, measles. However, ITP in association with coronavirus disease 2019 (COVID-19) vaccination has not reported so far. We describe cases of two young girls affected presenting a quick reduction platelet count after receiving Pfizer-BioNTech...