A5056754635- Multiple Sclerosis Research Studies
- Hematopoietic Stem Cell Transplantation
- Polyomavirus and related diseases
- Acute Lymphoblastic Leukemia research
- Multiple Myeloma Research and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Lymphoma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Systemic Sclerosis and Related Diseases
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Renal Transplantation Outcomes and Treatments
- Mesenchymal stem cell research
- Biomedical Ethics and Regulation
- Transplantation: Methods and Outcomes
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Neutropenia and Cancer Infections
- Organ Donation and Transplantation
- Peripheral Neuropathies and Disorders
- Organ Transplantation Techniques and Outcomes
- Lipid metabolism and disorders
- Organ and Tissue Transplantation Research
Baylor College of Medicine
2023
St. Luke's Hospital
2022
Clínica Ruiz
2015-2021
Benemérita Universidad Autónoma de Puebla
2015-2021
Universidad Popular Autónoma del Estado de Puebla
2019-2021
<b><i>Background:</i></b> With the goal of achieving immune system reset, autologous hematopoietic stem cell transplantations have been performed in patients with multiple sclerosis (MS). <b><i>Material and Methods:</i></b> Two hundred eighty-six consecutive MS were autografted a single center using non-frozen peripheral blood cells (PBSCs), on an outpatient basis conditioning cyclophosphamide rituximab. The protocol was registered...
In order to reset the immune system baseline function, autologous hematopoietic stem cell transplantation (HSCT) has been performed in patients with multiple sclerosis (MS). After June 2015, 617 new consecutive MS were autografted our center non-frozen peripheral blood cells. The autografts on an out-patient basis, after conditioning cyclophosphamide and rituximab. aim of study was assessment both safety efficacy method. study's primary co-end-points recovery granulocyte platelet counts...
Persons with multiple sclerosis are increasingly treated intermediate- or high-dose chemotherapy and a hematopoietic cell autotransplant. This is often done in an inpatient setting using frozen blood grafts.Determine if autotransplant can be safely outpatient refrigerated, non-frozen grafts.We developed protocol actionable graft collected after giving cyclophosphamide, 50 mg/kg/d × 2 days filgrastim, 10 μg/kg/d. A second identical course was given 9 later followed by infusion of cells stored...
<b><i>Background:</i></b> The treatment of patients with multiple myeloma (MM) has evolved in recent years, and the disease-associated prognosis improved substantially. This improvement been driven largely by approval novel agents, many which are expensive not universally available. Less but effective approaches would be value globally. <b><i>Patients Methods:</i></b> All consecutive MM diagnosed Centro de Hematología y Medicina Interna Puebla...
We have previously shown that some patients present thrombocytopenia (less than 100 × 109/L platelets) in non-alcoholic fatty liver disease (NAFLD). To further explore the nature of this association, we now analyzed association with neutropenia 0.5 granulocytes) NAFLD.Persons NAFLD were prospectively accrued study after February 2018. The presence was defined by both serologic determinations (Fibromax ®) and transient elastography (TE/Fibroscan ®).In 123 consecutive without cirrhosis,...
Processes that activate the immune system during lung transplantation can lead to primary graft dysfunction (PGD) or allograft rejection.We analyzed cytokine expression profiles after reperfusion and outcomes in a cohort of patients (n = 59) who underwent off-pump 26), with cardiopulmonary bypass (CPB; n 18), extracorporeal membrane oxygenation (ECMO; 15). Peripheral blood was collected from at baseline 6 72 h reperfusion. To adjust for clinical differences between groups, we utilized linear...
Admission to the intensive care unit (ICU) of a patient who has been grafted with hematopoietic stem cells is serious event, but role ICU in this setting remains controversial. Data were analyzed from patients underwent autologous or allogeneic bone marrow transplantation at Centro de Hematología y Medicina Interna Puebla, México, between May 1993 and October 2014. In total, 339 grafted: 150 autografts 189 allografts; 68 (20%) admitted after transplantation: 27% allografted 11% autografted...
Background: Sticky platelet syndrome (SPS) is a common but under-recognized cause of thrombosis. Treatment with antiplatelet drugs results in low re-thrombosis rate. The aim this study to analyze the treatment persons SPS different parts world. Methods: Data from 43 publications describing 1,494 patients worldwide were analyzed. concerning was available 16 these papers, and involving 332 patients. Results: Three hundred thirty two treated drugs; 303 given solely aspirin 29 received...
Objective: Sticky platelet syndrome (SPS) is an inherited condition that leads to arterial and venous thrombosis.There scant information about the association between SPS obstetric complications.This study aimed assess relationship fetal loss at a single institution. Materials Methods:The histories of all consecutive female patients prospectively studied in 324-month period institution with history thrombosis clinical marker primary thrombophilia were reviewed.Results: Between 1989 2016, 268...
Thrombocytopenia (less than 100 × 10 9 /L platelets) presents in around one quarter of patients with nonalcoholic fatty liver disease (NAFLD), the hepatic component insulin resistance (IR). It is unknown whether IR, by itself, associates thrombocytopenia. Persons NAFLD and/or IR were prospectively accrued study after February 2018. Insulin was defined assessing α hydroxybutyrate, lynoleoyl glycerolphosphocoline, oleic acid, and (Quantose IR), whereas presence serologic determinations...
Background:The biology of some hematological diseases varies among different populations.No previous studies have evaluated the clinical behavior mantle cell lymphoma (MCL) in México.Objective and Methods: This is a retrospective review MCL cases seen Mexico from January 2003 to June 2020.A total 12 were identified.Results: There nine males three females; median age was 56 years.Eight patients had high international prognostic index score, one intermediate, low.Five circulating malignant...
Donor cell leukemia (DCL) is a rare complication of hematopoietic stem transplantation (HSCT). Its incidence has been reported between 0.12 and 5%, although the majority cases are anecdotal. The mechanisms leukemogenesis in DCL may be distinct from other types leukemia. Here we describe case 27-year-old woman with diagnosis biphenotypic acute who received HSCT developed DCL. We briefly discuss possible pathogenesis, diagnosis, treatment
Introduction: Although therapeutic choices for patients with chronic lymphocytic leukemia (CLL) were once limited, treatment of this disease has vastly improved in the last decades.Patients and methods: Consecutive CLL diagnosed a single institution analyzed. Treatment was withheld persons Rai stage 0 or 1, until progression stages 2-4, negative expression ZAP-70 progression. Between 1983 1991, give chlorambucil prednisone (CP); after 1991 fludarabine cyclophosphamide (FC) 1998, rituximab FC...
The outcomes of Hodgkin´s lymphoma (HL) in México have not been widely reported. Simplified and affordable treatments adopted middle-income countries.The aim was to evaluate long-used therapies for HL a long-term basis.In 34-year time period, 88 patients with were treated at single institution México. Patients adriamycin bleomycin vinblastine dacarbazine (ABVD) or mechlorethamine, vincristine, procarbazine, prednisone (MOPP). Relapsed refractory given ifosfamide, carboplatin, etoposide (ICE)...