A5032041662- Machine Learning in Materials Science
- Transplantation: Methods and Outcomes
- Cancer Immunotherapy and Biomarkers
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Immune Cell Function and Interaction
- Coastal wetland ecosystem dynamics
- Computational Drug Discovery Methods
- Neural Networks and Applications
- Lung Cancer Research Studies
- Brain Metastases and Treatment
- Cancer Genomics and Diagnostics
- Titanium Alloys Microstructure and Properties
- Evolutionary Algorithms and Applications
- Cancer-related molecular mechanisms research
- Climate change and permafrost
- Coral and Marine Ecosystems Studies
- Machine Learning and Data Classification
- Face and Expression Recognition
- Cryospheric studies and observations
- Aluminum Alloy Microstructure Properties
- Gene expression and cancer classification
- Immune cells in cancer
- Agricultural and Environmental Management
- X-ray Diffraction in Crystallography
Rice University
2021-2025
The University of Texas MD Anderson Cancer Center
2024
Tsinghua University
2023-2024
Significant efforts have been invested to restore mangrove forests worldwide through reforestation and afforestation. However, blue carbon benefit has not compared between these two silvicultural pathways at the global scale. Here, we integrated results from direct field measurements of over 370 restoration sites around world show that (reestablishing mangroves where they previously colonized) had a greater storage potential per hectare than afforestation (establishing mangrove). Greater...
Significant efforts have been invested to restore mangrove forests worldwide through reforestation and afforestation. However, blue carbon benefit has not compared between these two silvicultural pathways at the global scale. Here, we integrated results from direct field measurements of over 370 restoration sites around world show that (reestablishing mangroves where they previously colonized) had a greater storage potential per hectare than afforestation (establishing mangrove). Greater...
Abstract Mangrove ecosystems are highly productive, sequestering large amounts of carbon from the atmosphere while emitting relatively low levels greenhouse gases. Large organic matter and nitrogen river discharge may stimulate production emission gases including N2O, thus reducing blue storage capacity mangrove wetlands. However, it is unclear how input affect fluxes these in In this study, we compared effluxes N2O between estuarine non-estuarine wetlands near seven major rivers on Hainan...
Abstract In a phase 2 trial, local-regionally advanced HPV-positive oropharyngeal carcinoma patients (N = 35) received ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1) as induction immunotherapy concurrently with radiotherapy (NCT03799445). Co-primary endpoints included 6-month complete metabolic response rate (94%) 2-year progression-free survival (84%). Induction yielded 46% major histopathologic rate. Single-cell profiling revealed responders had higher baseline intratumoral CD8+ T...
The clinical use of circulating biomarkers for primary graft dysfunction (PGD) after lung transplantation has been limited. In a prospective single-center cohort, we examined the plasma protein as indicators PGD severity and duration transplantation. study comprised 40 consecutive transplant patients who consented to blood sample collection immediately pretransplant at 6, 24, 48, 72 h transplant. An expert grader determined scored T0 (6 reperfusion), T24, T48, T72 post-reperfusion using 2016...
Processes that activate the immune system during lung transplantation can lead to primary graft dysfunction (PGD) or allograft rejection.We analyzed cytokine expression profiles after reperfusion and outcomes in a cohort of patients (n = 59) who underwent off-pump 26), with cardiopulmonary bypass (CPB; n 18), extracorporeal membrane oxygenation (ECMO; 15). Peripheral blood was collected from at baseline 6 72 h reperfusion. To adjust for clinical differences between groups, we utilized linear...
Abstract Background Sex and hormones influence immune responses to ischemia reperfusion (IR) could, therefore, cause sex-related differences in lung transplantation (LTx) outcomes. We compared men’s women’s clinical molecular post-LTx IR. Methods In 203 LTx patients, we used the 2016 International Society for Heart Lung Transplantation guidelines score primary graft dysfunction (PGD). a subgroup of 40 patients with blood samples collected before (T0) 6, 24, 48 (T48), 72 h (T72) after...
In the emerging field of materials informatics, a fundamental task is to identify physicochemically meaningful descriptors, or genes, which are engineered from primary features and set elementary algebraic operators through compositions. Standard practice directly analyzes high-dimensional candidate predictor space in linear model; statistical analyses then substantially hampered by daunting challenge posed astronomically large number correlated predictors with limited sample size. We...
Feature selection (FS) methods often are used to develop data-driven descriptors (i.e., features) for rapidly predicting the functional properties of a physical or chemical system based on its composition and structure. FS algorithms identify from candidate pool feature space) built by engineering (FE) steps that construct complex features system's fundamental properties. Recursive FE, which involves repeated FE operations space, is necessary build with sufficient complexity capture behavior...
ABSTRACT In a phase 2 trial, local-regionally advanced HPV-positive oropharyngeal carcinoma (OPC) patients received ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1) as induction immunotherapy concurrently with radiotherapy ( NCT03799445 ). Co-primary endpoints achieved included 6-month complete metabolic response rate (94%) 2-year progression-free survival (84%). Induction yielded 46% major histological rate. Single-cell profiling revealed responders had higher baseline intratumoral...
Symbolic regression (SR) is a powerful technique for discovering symbolic expressions that characterize nonlinear relationships in data, gaining increasing attention its interpretability, compactness, and robustness. However, existing SR methods do not scale to datasets with large number of input variables (referred as extreme-scale SR), which are common modern scientific applications. This ``large $p$'' setting, often accompanied by measurement error, leads slow performance overly complex...
<h3>Background</h3> Pathological response to neoadjuvant ICB is established as a biomarker of long-term disease control in several solid tumors.<sup>1</sup> To determine tumor microenvironment (TME) features associated with pathological response, we performed single-cell profiling on matched baseline and on-treatment biopsies from patients newly diagnosed HPV-positive OPC enrolled phase 2 trial 6-week cycle induction ipilimumab (anti-CTLA-4) nivolumab (anti-PD-1) prior radiotherapy.<sup>2...
6056 Background: Combination CTLA-4 and PD-1 ICB results in durable responses patients with recurrent metastatic HNSCC therefore justifies further investigation the induction or neoadjuvant setting. Methods: We investigated features of tumor immune microenvironment (TIME) associated MHR after newly diagnosed HPV-positive HNSCC. Tumor samples were collected at baseline on treatment from 31 enrolled a phase 2 trial 6-week cycle followed by dose/volume-adapted IMRT (50-66Gy) concurrent 2....
In the emerging field of materials informatics, a fundamental task is to identify physicochemically meaningful descriptors, or genes, which are engineered from primary features and set elementary algebraic operators through compositions. Standard practice directly analyzes high-dimensional candidate predictor space in linear model; statistical analyses then substantially hampered by daunting challenge posed astronomically large number correlated predictors with limited sample size. We...