A5017558185- Cervical Cancer and HPV Research
- Head and Neck Cancer Studies
- Cancer-related Molecular Pathways
- Microtubule and mitosis dynamics
- Neuroblastoma Research and Treatments
- Molecular Biology Techniques and Applications
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Bacteriophages and microbial interactions
- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
- Cleft Lip and Palate Research
- Cancer Immunotherapy and Biomarkers
- Oral Health Pathology and Treatment
- Plant Disease Resistance and Genetics
- Lung Cancer Treatments and Mutations
- Retinal Diseases and Treatments
- RNA modifications and cancer
- Bone and Joint Diseases
- Viral Infections and Immunology Research
- Colorectal and Anal Carcinomas
- Viral-associated cancers and disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hematological disorders and diagnostics
- Lung Cancer Research Studies
The University of Texas MD Anderson Cancer Center
2018-2025
National Cancer Institute
2011-2023
Cancer Research Center
2011-2023
Sidney Kimmel Comprehensive Cancer Center
2004-2023
Beijing University of Chinese Medicine
2022
Wuhan No.1 Hospital
2022
China Mobile (China)
2021
The Ohio State University
2010-2017
National Institutes of Health
2011-2017
Johns Hopkins Hospital
2008-2012
Recent increases in incidence and survival of oropharyngeal cancers the United States have been attributed to human papillomavirus (HPV) infection, but empirical evidence is lacking.
High-risk types of human papillomavirus (HPV), including HPV-16, cause a subgroup head and neck squamous cell carcinomas (HNSCCs). We examined whether the risk factors for HPV-16-positive HNSCCs are similar to those HPV-16-negative in hospital-based case-control study.Case subjects (n = 240) diagnosed with HNSCC at Johns Hopkins Hospital from 2000 through 2006 were stratified by tumor HPV-16 status as determined situ hybridization. Two control 322) without cancer individually matched age sex...
Human papillomavirus (HPV) infection is the principal cause of a distinct form oropharyngeal squamous cell carcinoma that increasing in incidence among men United States. However, little known about epidemiology oral HPV infection.To determine prevalence States.A cross-sectional study was conducted as part National Health and Nutrition Examination Survey (NHANES) 2009-2010, statistically representative sample civilian noninstitutionalized US population. Men women aged 14 to 69 years examined...
Purpose Tobacco smoking is associated with oropharynx cancer survival, but to what extent progression or death increases increasing tobacco exposure unknown. Patients and Methods enrolled onto a phase III trial of radiotherapy from 1991 1997 (Radiation Therapy Oncology Group [RTOG] 9003) chemoradiotherapy 2002 2005 (RTOG 0129) were evaluated for tumor human papillomavirus status by surrogate, p16 immunohistochemistry, standardized questionnaire. Associations between overall survival (OS)...
Genomic instability is a hallmark of human cancers, including the 5% caused by papillomavirus (HPV). Here we report striking association between HPV integration and adjacent host genomic structural variation in cancer cell lines primary tumors. Whole-genome sequencing revealed integrants flanking bridging extensive amplifications rearrangements, deletions, inversions, chromosomal translocations. We present model “looping” which integrant-mediated DNA replication recombination may result...
Tumor human papillomavirus (HPV) status is a prognostic factor for oropharyngeal cancer, but classification methods are not standardized. Here we validate the HPV used in US cooperative group trials. DNA and RNA purified from 240 paraffin-embedded cancers diagnosed 2000 to 2009 were scored as evaluable if positive mRNA controls by quantitative polymerase chain reaction (PCR). Eighteen high-risk (HR) types detected tumors consensus PCR, followed HR-HPV E6/7 oncogene expression analysis...
Human papillomavirus (HPV) is a cause of oropharyngeal cancer, but role for HPV in the etiology oral cavity squamous cell carcinomas (OCSCC) remains uncertain.We sought to estimate etiologic fraction among consecutive, incident OCSCC diagnosed from 2005 2011 at four North American hospitals. DNA and RNA purified paraffin-embedded tumors were considered evaluable if positive mRNA control genes by quantitative PCR. Fifteen high-risk (HR) types detected consensus PCR followed type-specific...
Purpose The incidence of human papilloma virus (HPV)-positive oropharyngeal cancers has risen rapidly in recent decades among men the United States. We investigated US population-level effect prophylactic HPV vaccination on burden oral infection, principal cause HPV-positive cancers. Methods conducted a cross-sectional study and women 18 to 33 years age (N = 2,627) within National Health Nutrition Examination Survey 2011 2014, representative sample population. Oral infection with vaccine...
PURPOSE Recent increases in incidence and survival of oropharyngeal cancers the United States have been attributed to human papillomavirus (HPV) infection, but empirical evidence is lacking. PATIENTS AND METHODS HPV status was determined for all 271 (1984-2004) collected by three population-based cancer registries Surveillance, Epidemiology, End Results (SEER) Residual Tissue Repositories Program using polymerase chain reaction genotyping (Inno-LiPA), HPV16 viral load, mRNA expression....
Human papillomavirus (HPV) is a necessary but insufficient cause of subset oral squamous cell carcinomas (OSCCs) that increasing markedly in frequency. To identify contributory, secondary genetic alterations these cancers, we used comprehensive genomics methods to compare 149 HPV-positive and 335 HPV-negative OSCC tumor/normal pairs. Different behavioral risk factors underlying the two types were reflected distinctive genomic mutational signatures. In OSCCs, signatures APOBEC cytosine...
Abstract The human papillomavirus (HPV) genome is integrated into host DNA in most HPV-positive cancers, but the consequences for chromosomal integrity are unknown. Continuous long-read sequencing of oropharyngeal cancers and cancer cell lines identified a previously undescribed form structural variation, “heterocateny,” characterized by diverse, interrelated, repetitive patterns concatemerized virus segments within cancer. Unique breakpoints shared across variants facilitated stepwise...
Imperfect maintenance of genome integrity has been postulated to be an important cause aging. Here we provide support for this hypothesis by demonstrating that the disruption PASG ( lsh ), a SNF2-like factor facilitates DNA methylation, causes global hypomethylation, developmental growth retardation and premature aging phenotype. mutant mice display signs aging, including low birth weight, failure thrive, graying loss hair, reduced skin fat deposition, osteoporosis, kyphosis, cachexia,...
Oral human papillomavirus (HPV) infection is a cause of oropharyngeal squamous cell carcinoma, yet little known about the epidemiology and natural history infection.At baseline 3-month follow-up visit, 1000 young adults aged 18 to 30 years provided an oral rinse sample completed survey assessing demographic behavioral risk factors. The was analyzed for 37 types HPV by use multiplex polymerase chain reaction assay. Factors associated with detection were using univariate bivariate logistic...
Human papillomavirus (HPV) causes the majority of oropharyngeal cancers in United States, yet risk factors for and natural history oral HPV infection are largely unknown. In 2010-2011, a US-based longitudinal cohort study 761 human immunodeficiency virus (HIV)-infected 469 at-risk HIV-uninfected participants from Multicenter AIDS Cohort Study Women's Interagency HIV was initiated. Semiannually collected rinses were evaluated 37 genotypes using Roche LINEAR ARRAY Genotyping Test (Roche...
The incidence of human papillomavirus (HPV)-positive oropharyngeal cancers is higher and increasing more rapidly among men than women in the United States for unknown reasons. We compared epidemiology oral oncogenic HPV infection between ages 14 to 69 years (N = 9,480) within U.S. National Health Nutritional Examination Surveys (NHANES) 2009-2012. presence was detected DNA by PCR. Analyses were stratified gender used NHANES sample weights. Oral prevalence (6.6% vs. 1.5%, P < 0.001),...
Abstract Oral squamous cell carcinomas are a major cause of morbidity and mortality, tobacco usage, alcohol consumption, poor oral hygiene established risk factors. To date, no large-scale case-control studies have considered the effects these factors on composition microbiome, nor microbial community associations with cancer. We compared composition, diversity, function microbiomes 121 cancer patients to 242 age- gender-matched controls using metagenomic multivariate analysis pipeline....
<h3>Importance</h3> Human papillomavirus–related oropharyngeal carcinoma (HPV-OPC) is increasing in incidence the United States. Although HPV-OPC has favorable prognosis, 10% to 25% of HPV-OPCs recur. Detection human papillomavirus (HPV) DNA oral rinses associated with HPV-OPC, but its potential as a prognostic biomarker unclear. <h3>Objective</h3> To determine whether HPV detection after treatment for recurrence and survival. <h3>Design, Setting, Participants</h3> Prospective cohort study...
Detection of persistent oral human papillomavirus (HPV) DNA may be associated with recurrence HPV-positive head and neck squamous cell carcinoma (HNSCC).To evaluate the dynamics HPV detection associations disease outcomes in patients HPV-negative HNSCC.This prospective, 2-institution, tertiary referral center study 396 newly diagnosed cavity or oropharyngeal HNSCC was performed from July 11, 2011, to May 7, 2016. Oral rinse samples were prospectively collected at diagnosis completion primary...
Abstract Oral human papillomavirus genotype 16 (HPV16) infection causes oropharyngeal squamous cell carcinoma (SCC), and the prevalence of SCC is higher among men than women in United States. In a cohort study oral HPV 409 individuals aged 18–25 years, risk but not significantly increased as number recent (ie, within prior 3 months) sex partners (Pinteraction = .05). contrast, decreased lifetime vaginal .037). Men were also less likely to clear infection. Our data contribute understanding...
Abstract Background: While detection of circulating tumor DNA (ctDNA) weeks after surgery is linked to recurrence for other solid tumors, the optimal time point ctDNA assessment as a prognostic biomarker following chemoradiation anal cancer undefined. Methods: Patients with stages I-III treated between 12/2020-5/2024 were evaluated HPV status at baseline, end chemoradiation, and during surveillance using droplet digital PCR assay targeting E6 E7 oncogenes 13 oncogenic types. Median...
The exudative, or the wet form of age-related macular degeneration (AMD) is characterized by choroidal neovascularization (CNV). A subretinal Matrigel (BD Biosciences, Bedford MA) model CNV described here, along with effects vascular endothelial growth factor (VEGF) neutralization on development and associated inflammation fibrosis.CNV was induced in adult Sprague-Dawley rats injection Matrigel. leukocyte infiltration collagen deposition were examined. VEGF Trap (Regeneron Pharmaceuticals,...
To estimate changes in oral human papillomavirus (HPV) prevalence attributable to vaccination vs herd immunity, this national survey study uses National Health and Nutrition Examination Survey data compare HPV for 4 types targeted by vaccine 33 nonvaccine unvaccinated US adults aged 18 59 years from 2009 2016.
Human papillomavirus (HPV) causes 5% of all cancers and frequently integrates into host chromosomes. The HPV oncoproteins E6 E7 are necessary but insufficient for cancer formation, indicating that additional secondary genetic events required. Here, we investigate potential oncogenic impacts virus integration. Analysis 105 HPV-positive oropharyngeal by whole-genome sequencing detects integration in 77%, revealing five statistically significant sites recurrent near genes regulate epithelial...
In this study, the hypothesis that increased intraocular levels of iron cause oxidative damage to retina was tested.Adult C57BL/6 mice were given an intravitreous injection saline or 0.10, 0.25, 0.50 mM FeSO(4). Scotopic electroretinograms (ERGs) performed 3, 7, and 14 days after injection, photopic ERGs on day 14. Hydroethidine used identify superoxide radicals lipid peroxidation visualized by staining for hydroxynonenal (HNE). Retinal cell death evaluated TUNEL measurement inner nuclear...