A5089634217- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Appendicitis Diagnosis and Management
- Advanced biosensing and bioanalysis techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Gallbladder and Bile Duct Disorders
- Radiology practices and education
- Radiation Dose and Imaging
- Gold and Silver Nanoparticles Synthesis and Applications
- Intestinal and Peritoneal Adhesions
- Hernia repair and management
- Hip and Femur Fractures
- Plant-based Medicinal Research
- Hospital Admissions and Outcomes
- Gastrointestinal disorders and treatments
- Intestinal Malrotation and Obstruction Disorders
- Nanocluster Synthesis and Applications
- Abdominal Trauma and Injuries
- Neuroendocrine Tumor Research Advances
- Healthcare Operations and Scheduling Optimization
- Nanoplatforms for cancer theranostics
- Advanced Biosensing Techniques and Applications
- Advanced X-ray and CT Imaging
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Bleeding Diagnosis and Treatment
Ealing Hospital
2023-2025
London North West Healthcare NHS Trust
2019-2025
Imperial College London
2013-2020
Hammersmith Hospital
2013-2020
Northwick Park Hospital
2019
Glangwili General Hospital
2011-2018
London Centre for Nanotechnology
2015-2017
West Middlesex University Hospital
2017
London Postgraduate Medical and Dental Education
2017
Royal Manchester Children's Hospital
2015
Glypican-1 (GPC1) is expressed in pancreatic ductal adenocarcinoma (PDAC) cells and adjacent stromal fibroblasts. Recently, GPC1 circulating exosomes (crExos) have been shown to be able detect early stages of PDAC. In this study, we investigated the usefulness crExos as a biomarker for PDAC.Plasma was obtained from patients with benign disease (n = 16) PDAC 27) prior pancreatectomy, were isolated by ultra-centrifugation. Protein extracted surgical specimens (adjacent normal pancreas, n 13;...
Gold nanostars (AuNSs) are receiving increasing attention for their potential applications in bionanotechnology because of unique optical properties related to complex branched morphology. Their sharp features allow strong localized surface plasmon resonances, tunable the near-infrared (NIR) region, and large enhancements local electromagnetic fields. Here, application AuNSs metal-enhanced fluorescence (MEF) NIR second (NIR-II) biological windows is explored first time. NIR/NIR-II...
Abstract Background Although laparoscopic cholecystectomy (LC) is considered a low-risk procedure, intraoperative bleeding, bile duct injury and leak occur frequently in the ‘difficult’ gallbladder. Robotic (RC) can overcome difficulties related to poor vision instrumentation difficult cases avoid complications conversion open surgery. The aim of study was evaluate outcomes robotic patients with gallbladders referred tertiary HPB centre. Methods We conducted retrospective review all senior...
The amplification of light in NIR-II from Ag2S QDs via metal enhanced fluorescence (MEF) is reported for the first time. Significant enhancement over 100 times deposited on Au-nanostructured arrays, paves way novel sensing and imaging applications based QDs, with improved detection sensitivity contrast enhancement.
Abstract Plasmonic gold (Au) nanotriangular arrays, functionalized with a near infrared (NIR) fluorophore-conjugated immunoassay to Carbohydrate Antigen 19-9 (CA 19-9), pancreatic cancer biomarker, produce optically tunable substrates two orders of magnitude fluorescence enhancement. Through nanoscale morphological control, the sensitivities plasmonic arrays are controllable, paving way such optical platforms for multiplexing. Here, we report limit detection (LOD) 7.7 × 10 −7 U.mL −1 CA 19–9...
Colonoscopic polypectomy is a routine procedure with the potential for rare but well-known complications, including perforation and bleeding. Post-polypectomy electrocoagulation syndrome (PPES) less recognized cause of abdominal pain following this procedure. However, it important to diagnose PPES in order avoid unnecessary intervention. We present case patient after polypectomy. The underwent an diagnostic laparoscopy on basis misinterpreted radiological findings. Her CT scan demonstrated...
Objective: This study evaluated the pathophysiology of amiodarone-induced peripheral neuropathy both in vivo and vitro. Background Amiodarone has been long known to cause neuropathy, but mechanism action is uncertain. Design/Methods: We performed mouse dorsal root ganglia neuronal Schwann cell cultures exposed a dose range amiodarone or placebo. examined cellular viability, reactive oxygen species mitochondrial function Complementary studies with either systemic (intraperitoneal),...
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