Nicolas Buton

ORCID: 0000-0002-4079-5501
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About
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Research Areas
  • Bone Tissue Engineering Materials
  • Dental materials and restorations
  • Dental Implant Techniques and Outcomes
  • Nanoparticle-Based Drug Delivery
  • Nanoparticles: synthesis and applications
  • Machine Learning in Bioinformatics
  • Distributed and Parallel Computing Systems
  • Polymer Surface Interaction Studies
  • Calcium Carbonate Crystallization and Inhibition
  • Iron oxide chemistry and applications
  • Machine Learning in Materials Science
  • Heavy Metal Exposure and Toxicity
  • Biomedical Text Mining and Ontologies
  • Ferroelectric and Piezoelectric Materials
  • Cell Image Analysis Techniques
  • Graphene and Nanomaterials Applications
  • Laser-Ablation Synthesis of Nanoparticles
  • Essential Oils and Antimicrobial Activity
  • Quantum Dots Synthesis And Properties
  • Collagen: Extraction and Characterization
  • Marine Biology and Environmental Chemistry
  • Agriculture and Rural Development Research
  • Pharmacological Effects of Natural Compounds
  • Polymer Synthesis and Characterization
  • Ultrasound and Cavitation Phenomena

Horiba (France)
2017-2024

Université de Rennes
2022-2023

Centre National de la Recherche Scientifique
2022-2023

Institut de Recherche en Informatique et Systèmes Aléatoires
2022-2023

National Institute of Materials Physics
2018-2023

Clinical Emergency Hospital Bucharest
2018

Universitatea Națională de Știință și Tehnologie Politehnica București
2018

Institute for Diagnosis and Animal Health
2018

University of Agronomic Sciences and Veterinary Medicine of Bucharest
2018

Carol Davila University of Medicine and Pharmacy
2018

This study proves that the new developed zinc-doped hydroxyapatite (ZnHAp) colloids by an adapted sol-gel method can be widely used in pharmaceutical, medical, and environmental industries. ZnHAp nanoparticles were stabilized aqueous solution, their colloidal dispersions have been characterized different techniques. Scanning Electron Microscopy (SEM) was to get information on morphology composition of investigated samples. Energy-dispersive X-ray spectroscopy (EDX) analysis confirmed...

10.3390/nano9040515 article EN cc-by Nanomaterials 2019-04-02

Obtaining nanoscale materials has allowed for the miniaturization of components, which led to possibility achieving more efficient devices with faster functions and much lower costs. While hydroxyapatite [HAp, Ca10(PO4)6(OH)2] is considered most widely used material medical applications in orthopedics, dentistry, general surgery, magnesium (Mg) viewed as a promising biodegradable biocompatible implant material. Furthermore, Mg regarded strong candidate developing implants due its...

10.3390/nano9091295 article EN cc-by Nanomaterials 2019-09-11

The present work was focused on the synthesis and characterization of hydroxyapatite doped with low concentrations zinc (Zn:HAp) (0.01 < xZn 0.05). incorporation Zn2+ ions in (HAp) structure achieved by co-precipitation method. physico-chemical properties samples were characterized X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), photoelectron spectroscopy (XPS), Scanning Electron Microscopy (SEM), zeta-potential, DLS N2-BET measurements. results obtained XRD FTIR...

10.3390/ma10030229 article EN Materials 2017-02-25

This study presents, for the first-time, results of a on hydrodynamic diameter essential oils (EOs) basil and lavender in water, solutions EOs (B) (L) hydroxyapatite (HAp). The possible influence size nanoparticles was analyzed by Scanning Electron Microscopy (SEM). We also investigated vitro antimicrobial activity plant respectively, against Gram-positive bacteria (methicillin-resistant Staphylococcus aureus1144 (MRSA 1144) S. aureus 1426) Gram-negative (Escherichia coli ATCC 25922...

10.3390/nano8050291 article EN cc-by Nanomaterials 2018-04-30

The present study is focused on the synthesis, characterization and antifungal evaluation of zinc-doped hydroxyapatite (Zn:HAp) coatings. Zn:HAp coatings were deposited a pure Si (Zn:HAp_Si) Ti (Zn:HAp_Ti) substrate by sol-gel dip coating method using nanogel. nature crystal phase was determined X-ray diffraction (XRD). crystalline prepared composite assigned to hexagonal in P63/m space group. colloidal properties resulting (xZn = 0.1) nanogel analyzed Dynamic Light Scattering (DLS) zeta...

10.3390/molecules22040604 article EN cc-by Molecules 2017-04-09

In this study, ZnHAp layers deposited on a Si substrate were obtained by sol–gel spin-coating procedure. The solutions used to obtain the coatings investigated dynamic light scattering (DLS) analysis, ζ-potential, ultrasound measurements, and flame atomic absorption spectrometry (AAS). average measured hydrodynamic diameter from DLS measurements analyzed so as characterize estimate stability of nanoparticles. AAS results confirmed presence zinc in gels preparation layers. X-ray diffraction...

10.3390/coatings9030156 article EN Coatings 2019-02-28

It is known that iron found as a trace element in bone tissue, the main inorganic constituent of which hydroxyapatite. Therefore, iron-doped hydroxyapatite (HApFe) materials could be new alternatives for many biomedical applications. A facile dip coating process was used to elaborate nanocomposite coatings. The HApFe suspension prepare coatings achieved using co-precipitation method, adapted laboratory. quality assessed through dynamic light scattering (DLS), ultrasonic measurements, and...

10.3390/coatings11020186 article EN Coatings 2021-02-05

A simple dip coating procedure was used to prepare the magnesium doped hydroxyapatite coatings. An adapted co-precipitation method in order obtain a Ca25−xMgx(PO4)6(OH)2, 25MgHAp (xMg = 0.25) suspension for preparing The stabilities of suspensions were evaluated using ultrasound measurements, zeta potential (ZP), and dynamic light scattering (DLS). Using transmission electron microscopy (TEM) scanning (SEM) information at nanometric resolution regarding shape distribution particles obtained....

10.3390/coatings10060510 article EN Coatings 2020-05-27

Infections related to orthopedic/stomatology surgery are widely recognized as a significant health concern. Therefore, the development of new materials with superior biological properties and good stability could represent valuable alternative classical treatments. In this paper, fluorine-substituted hydroxyapatite (FHAp) suspension, chemical formula Ca10(PO4)6(OH)2−2xF2x (where x = 0.05), was prepared using modified coprecipitation technique. Stability studies were conducted by zeta...

10.3390/ma17143404 article EN Materials 2024-07-10

The objective of this study consisted the development new materials with antimicrobial properties at nanometric scale that could lead to an increase in therapeutic efficacy and reduction toxic side effects. This work focuses on obtaining characterizing stable suspensions narrow size distribution properties. stability obtained by adapted co-precipitation method was evaluated ultrasonic measurements. particle populations were determined using scanning electron microscopy (SEM), dynamic light...

10.3390/antibiotics12010074 article EN cc-by Antibiotics 2022-12-31

Abstract Motivation There is a growing number of available protein sequences, but only limited amount has been manually annotated. For example, 0.25% all entries UniProtKB are reviewed by human annotators. Further developing automatic tools to infer function from sequence alone can alleviate part this gap. In article, we investigate the potential Transformer deep neural networks on specific case functional annotation: prediction enzymatic classes. Results We show that our EnzBert transformer...

10.1093/bioinformatics/btad620 article EN cc-by Bioinformatics 2023-10-01

This study aims to design and test different formulations composed of dextran-coated iron oxide nanoparticles (IONPs) loaded with 5-Fluorouracil (5-FU) varying nanoparticle:drug ratios on colorectal cancer cells. The stable suspension IONPs s was synthesized by the adapted co-precipitation method. mixed a solution dextran 5-FU solubilized in saline solution. final suspensions optimized IONP:5-FU were 0.5:1, 1:1, 1.5:1. information morphology size distribution IONP loads obtained using...

10.3390/nano13121811 article EN cc-by Nanomaterials 2023-06-06

The dextran-thyme magnesium-doped hydroxyapatite (10MgHAp-Dex-thyme) composite layers were prepared by a dip-coating procedure from stable suspensions and further analyzed for the first time. Different characterization techniques employed to explore physical-chemical features of 10MgHAp-Dex-thyme derived coatings. Information regarding was extracted on basis dynamic light scattering, zeta potential, ultrasound measurements. crystalline quality biocomposite powders—resulting after...

10.3390/coatings10010057 article EN Coatings 2020-01-09

Owing to its unique biological and physicochemical properties, hydroxyapatite (HAp) represents one of the most extensively studied biomaterials for biomedical applications. It is well known that Candida currently fungi frequently involved in onset development post-implant infections and, owing appearance antifungal resistance, it quite difficult treat despite all tremendous efforts made this regard by scientific world. Therefore, context, we report first time paper, characterization...

10.3390/coatings12030306 article EN Coatings 2022-02-24

Abstract Cu-doped hydroxyapatite (CuHAp) thin films were obtained using spin coating method. To make these films, CuHAp suspensions by sol–gel method used. The coatings thermally treated at 500 °C. After the thermal treatment, characterized X-ray diffraction (XRD), scanning electron microscopy (SEM). Moreover, stability of before being used to obtain was certified dynamic light scattering (DLS), zeta potential methods and ultrasound measurements. In XRD patterns, peaks associated with...

10.1007/s10534-024-00620-2 article EN cc-by BioMetals 2024-07-29

Iron oxide nanoparticles have been extensively studied for challenges in applicable areas such as medicine, pharmacy, and the environment. The functionalization of iron with dextran opens new prospects application. Suspension characterization methods dynamic light scattering (DLS) zeta potential (ZP) allowed us to obtain information regarding stability hydrodynamic diameter these suspended particles. For rigorous suspension dextran-coated (D-MNPs), studies performed using ultrasound...

10.3390/coatings9120773 article EN Coatings 2019-11-20

A magnesium-doped hydroxyapatite in chitosan matrix (MgHApC) sample was developed as a potential platform for numerous applications the pharmaceutical, medical, and food industries. Magnesium-doped suspensions were obtained by coprecipitation technique. The surface shape morphological features determined scanning electron microscopy (SEM). hydrodynamic diameter of suspended particles Dynamic light scattering (DLS) measurements. stability MgHApC evaluated ultrasonic suspension 29.5 nm....

10.3390/biomimetics8070528 article EN cc-by Biomimetics 2023-11-06

Presently, iron oxide nanoparticles are the only ones approved for clinical use as contrast agents in magnetic resonance imaging (MRI). Even though there is a high demand these types of both well research, difficulties obtaining stable with reproducible properties. In this context, study, we report by an adapted coprecipitation method dextran-coated maghemite (ɤ-Fe2O3 NPs). The morphology and structure NPs) were determined using scanning electron microscopy (SEM) transmission (TEM). TEM SEM...

10.3390/pharmaceutics15020552 article EN cc-by Pharmaceutics 2023-02-07

The present research is focused on the synthesis, structural and morphological characterization antimicrobial evaluation of silver doped hydroxyapatite (AgHAp) in water. preliminary ultrasonic characterizations AgHAp water synthesized by an adapted co-precipitation method are also presented. X-ray diffraction result showed that ions were substituted structure. lattice parameters increased when substitution increased. morphology evaluated Scanning Electron Microscopy (SEM). By EDX analysis...

10.1063/1.5024184 article EN AIP conference proceedings 2018-01-01

Iron oxide-dextran nanoparticle suspensions (IOD-NPsS) have attracted attention for their considerable applications in various biomedical area such as cosmetics, water remediation, hyperthermia, drug delivery or magnetic resonance imaging (MRI) contrast enhancement. In these research we report the antimicrobial studies on iron colloidal suspension against prokaryotic cells Escherichia coli (E. coli). The ultrasound and dynamic light scattering (DLS) of suspensions. According oxide...

10.1063/1.5045967 article EN AIP conference proceedings 2018-01-01
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