A5061543540- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactions of Organic Compounds
- Synthesis and Biological Evaluation
- Synthesis of Organic Compounds
- Carcinogens and Genotoxicity Assessment
- Synthesis of heterocyclic compounds
- Quinazolinone synthesis and applications
- Chemical synthesis and pharmacological studies
- Click Chemistry and Applications
- Synthesis and Biological Activity
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- X-ray Diffraction in Crystallography
- HIV/AIDS drug development and treatment
- Synthesis and Catalytic Reactions
- Graphene and Nanomaterials Applications
- Nanoparticles: synthesis and applications
- Multicomponent Synthesis of Heterocycles
- Crystallization and Solubility Studies
- Nanoparticle-Based Drug Delivery
- Pneumocystis jirovecii pneumonia detection and treatment
- Effects and risks of endocrine disrupting chemicals
- Radiation Effects and Dosimetry
Institute of Fine Organic Chemistry of Scientific - Technological Center of Organic and Pharmaceutical Chemistry
2012-2025
National Academy of Sciences of Armenia
2006-2024
National Academy of Sciences
2019
The primary aim of the study was to investigate impact tar and nicotine contents cigarettes on chromosomal damage in oral mucosa cells smokers. We monitored effect smoking different cigarette types (i.e., ultralight filter, light medium filter unfiltered cigarettes) induction nuclear anomalies including micronuclei (MN), broken eggs (BE), binucleates (BN), condensed chromatin (CC), karyorrhexis (KR), karyolysis (KL) pyknosis (P) exfoliated buccal cells. were collected from 83 healthy heavy...
Abstract We investigated the impact of cigarette smoking, daily exposure to tar and nicotine, duration smoking on genetic instability (chromosomal damage – micronuclei, MN, nuclear buds - gene amplification) as well disturbances in mitosis (resulting binucleated cells). Furthermore, we analyzed markers cytotoxic effects (such formation condensed chromatin, pyknotic, karyolytic, karyorrhectic cells) mitotic activity oral mucosa. These parameters were monitored groups old (postmenopausal)...
Continuing our research in the field of new heterocyclic compounds, herein we report on synthesis and antitumor activity amino derivatives pyrido[3′,2′:4,5](furo)thieno[3,2-d]pyrimidines as well two systems: furo[2–e]imidazo[1,2-c]pyrimidine furo[2,3-e]pyrimido[1,2-c]pyrimidine. Thus, by refluxing 8-chloro pyrido[3′,2′:4,5]thieno(furo)[3,2-d]pyrimidines with various amines, relevant pyrido[3′,2′:4,5]thieno(furo)[3,2-d]pyrimidin-8-amines were obtained. Further, cyclization some amines under...
In search of new biologically active compounds among 1,3-diazaadamantanes, we previously synthesized containing indole, isatin, quinoline, and pyrazole derivatives in the 2-nd position adamantane ring. Biological studies were carried out. Among them with antioxidant activity [1-3].In medical practice, drugs a pyridine ring are widely used: Tubazid, Ftavazide, Nicotine, Cordiamin [4]. 9-Հիդրօքսի-, 9-օքսո-, 9-մեթիլեն-1,5-(դիալկիլ-, մեթիլ-, ֆենիլ-, դիֆենիլ)-3,7-դիազաբիցիկլո/3.3.1/նոնանների և...
The systemic therapeutic application of iodophores has not yet been accepted due to limited availability safe and effective ionized iodine preparations. Here we evaluated the antibacterial activity iodine-lithium-alpha-dextrin (ILalphaD) both in vitro vivo.The MIC values ILalphaD against 189 bacterial isolates various growth media vivo toxicity protective efficacy preventing mortality rats infected with Staphylococcus aureus were determined. intracellular killing S. by neutrophils presence...
In the present study, activity of new water-soluble cationic meso-tetra(4-N-oxyethylpyridyl)porphyrin and its Zn , Ag Co metal derivatives as anti-tumor agents was explored. The tumor induced by 7,12-dimethylbenz[a]antracene (DMBA) on rats Wistar strain. levels DNA damage porphyrins T4OEPyP AgT4OEPyP ZnT4OEPyP CoT4OEPyP in tissue were analyzed. Thermodynamic parameters investigated thermal melting method differential scanning microcalorimetry to understand differences structure three types...
Background: FS-1 is a complex of iodine and synthesized polysaccharides it very effective against number microbe virus strains. The aim the study was to evaluate possible genotoxic properties FS-1. Methods: compound studied in rat mouse bone marrow micronucleus (MN) assay comet murine peripheral blood leukocytes, hepatocytes, kidney cells. Two treatment protocols were applied, namely acute subacute ones. In first protocol, administered orally once two times, 24 h apart. animals sacrificed...