A5036646730- Immune Cell Function and Interaction
- HIV Research and Treatment
- Hepatitis C virus research
- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- RNA modifications and cancer
- Salmonella and Campylobacter epidemiology
- IL-33, ST2, and ILC Pathways
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Intramuscular injections and effects
- Blood groups and transfusion
- Vibrio bacteria research studies
- Blood Coagulation and Thrombosis Mechanisms
- Virology and Viral Diseases
- Monoclonal and Polyclonal Antibodies Research
- Acute Myeloid Leukemia Research
- Amoebic Infections and Treatments
- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- Genetics and Neurodevelopmental Disorders
- Viral Infections and Immunology Research
- interferon and immune responses
- Atrial Fibrillation Management and Outcomes
University of British Columbia
2009-2024
University of Toronto
2017
McMaster University
2017
Juravinski Hospital
2017
Terry Fox Research Institute
2014
BC Cancer Agency
2009-2014
Washington University in St. Louis
2009
Significance Sequences derived from transposable elements (TEs) are abundant in the human genome and can influence gene expression. In normal cells, most TEs silenced by epigenetic mechanisms such as DNA methylation but, cancer, normally dormant become active. We hypothesized that cancer-specific release of suppression could result expression perturbations, which promote oncogenesis. Using a bioinformatics method, we identified many genes expressed diffuse large B-cell lymphoma (DLBCL) via...
The human neuronal apoptosis inhibitory protein (NAIP) gene is no longer principally considered a member of the Inhibitor Apoptosis Protein (IAP) family, as its domain structure and functions in innate immunity also warrant inclusion Nod-Like Receptor (NLR) superfamily. NAIP located region copy number variation, with one full length four partly deleted copies reference genome. We demonstrate that several paralogues are expressed, novel transcripts arise from both internal upstream...
Natural cytotoxicity receptor 1 (NCR1), also known as NKp46, is a natural killer (NK) lymphocyte-activating receptor. It involved in major aspects of NK immune function and shows high degree lineage specificity blood bone marrow. The nature its NK-restricted expression not well understood. In this study, we confirm that human NCR1 NK-specific achieved at the mRNA level. We found two key cis-regulatory elements immediate vicinity upstream gene. One element acts an essential promoter, whereas...
Stochastic expression is a hallmark of the Ly49 family that encode main MHC class-I-recognizing receptors mouse natural killer (NK) cells. This highly polygenic and polymorphic includes both activating inhibitory receptor genes one genome's fastest evolving loci. The are expressed in stochastic mono-allelic manner, possibly under control an upstream bi-directional early promoter show DNA methylation patterns. To date, no studies have directly addressed transcriptional regulation receptors....
The fusion peptide of TBEV is a short segment the envelope protein that mediates viral and host cell membrane at acidic pH. Previous studies on E have shown mutations L107 an effect fusogenic activity. Structural also suggested during process rearranges to form trimer. In present study, number peptides were synthesized, their structure/activity was examined: (1) monomers consisting residues 93-113 wild-type with Leu position 107 (WT) two mutants, namely, L107F L107T; (2) monomer C105A...
The mouse gene for the natural killer (NK) cell-activating receptor Nkg2d produces two protein isoforms, NKG2D-S and NKG2D-L, which differ by 13 amino acids at N-terminus have different signalling capabilities. These isoforms are produced through differential splicing, but their regulation has not been investigated. In this study, we show that rat same splicing pattern as of mouse, mapped transcriptional start sites in both species. We found splice forms arise from alternative promoters...
Antiphospholipid syndrome (APS), cryoglobulinemia, and monoclonal gammopathies are variably accompanied by thrombotic complications. We describe a patient with recurrent skin microvascular thrombosis, APS, marginal zone lymphoma, IgMκ gammopathy, responsive to chemoimmunotherapy. The cryoglobulin fraction contained the paraprotein, while antiphospholipid antibodies (aPL) were predominantly in cryosupernatant. A retrospective analysis of aPL-positive patients our institution showed that 8.1%...
While anticoagulation therapy is highly effective at treating venous thromboembolism, some patients can develop rapidly progressive thrombosis in multiple organs or sites despite therapeutic anticoagulation. Effective strategies to manage life-threatening these are elusive.
Typhoid fever is a rare disease in North America. We present the case of 21-year-old female who developed invasive Salmonella typhi infection after returning from rural Pakistan. The patient presented with classic signs enteric including high fever, diarrhea, and tongue coated white patches. hematologic complications anemia splenic infarction. Investigations, imaging studies treatment are discussed. outlines both common uncommon typhoid reminds clinician its importance differential...
Background Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare complication of the ChAdOx1 nCoV-19 and Ad26.COV2.S COVID-19 vaccines. It presents most commonly with severe complications extremely high D-dimer levels 5–30 days after vaccination. We report patient who presented mild minimally elevated without thrombosis, but tested positive for antiplatelet factor 4 (PF4) platelet-activating antibodies on PF4-enhanced serotonin-release assay. Key Clinical Question Is...
Typhoid fever is a rare disease in North America. We present the case of 21-year-old female who developed invasive Salmonella typhi infection after returning from rural Pakistan. The patient presented with classic signs enteric including high fever, diarrhea, and tongue coated white patches. hematologic complications anemia splenic infarction. Investigations, imaging studies treatment are discussed. outlines both common uncommon typhoid reminds clinician its importance differential...