A5016367133- Analytical Chemistry and Sensors
- Semiconductor materials and devices
- Nanowire Synthesis and Applications
- Gas Sensing Nanomaterials and Sensors
- Advanced Memory and Neural Computing
- Microfluidic and Bio-sensing Technologies
- Advanced Sensor and Energy Harvesting Materials
- Microfluidic and Capillary Electrophoresis Applications
- Advancements in Semiconductor Devices and Circuit Design
- Graphene research and applications
- Electrowetting and Microfluidic Technologies
- Cutaneous lymphoproliferative disorders research
- Advanced biosensing and bioanalysis techniques
- Lymphoma Diagnosis and Treatment
- Biosensors and Analytical Detection
- Conducting polymers and applications
- Advanced Chemical Sensor Technologies
- Tumors and Oncological Cases
- Mycobacterium research and diagnosis
- Sarcoma Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- Fungal Infections and Studies
- Ferroelectric and Negative Capacitance Devices
- Neuroscience and Neural Engineering
- Organic Electronics and Photovoltaics
National Taiwan University
2016-2025
Chang Bing Show Chwan Memorial Hospital
2025
Yangzhou University
2024
National Central University
2024
University of Michigan
2004-2023
Cheng Hsin General Hospital
2013-2022
Chang Gung University
2009-2016
National Taiwan University Hospital
2004-2013
National Taipei University of Nursing and Health Science
2006-2013
Lunghwa University of Science and Technology
2007
PURPOSE: To prospectively evaluate lung parenchyma on paired inspiration-expiration thin-section computed tomographic (CT) scans in patients recovering from severe acute respiratory syndrome (SARS). MATERIALS AND METHODS: After the institutional review board approved study and written consent was obtained patients, 40 (25 female, 15 male; mean age, 42.8 years ± 12.3 [standard deviation]) underwent CT at 51.8 days 20.2 after onset of SARS symptoms. Twenty follow-up 140.7 26.7 symptom onset....
Biosensor research has been addressed as an interested field recently. Within different kinds of developed biosensing technologies, field-effect transistor (FET) based biosensors stand out due to their attractive features, such ultra-sensitivity detection, mass-production capability, and low-cost manufacturing. To promote understandings the FET technology, in this review, its sensing mechanism is introduced, well major FET-based devices: ion sensitive (ISFET), silicon nanowire, organic FET,...
A highly adaptive multi-sensor SoC comprising four integrated on-chip sensors and a smart wireless acquisition system is realized in standard CMOS process for the first time. To intelligently different types (C, R, I, V) of sensor signals, linear (R-square 0.999) reconfigurable readout proposed based on switched-capacitor circuit technology. In addition, dual-input energy harvesting interface with conversion efficiency 73% also to pick up light RF power, which potentiates long-term use...
The clinical picture of severe acute respiratory syndrome (SARS) is characterized by pulmonary inflammation and failure, resembling that distress syndrome. However, the events lead to recruitment leukocytes are poorly understood. To study cellular response in phase SARS coronavirus (SARS-CoV)-host cell interaction, we investigated induction chemokines, adhesion molecules, DC-SIGN (dendritic cell-specific ICAM-3-grabbing nonintegrin) SARS-CoV. Immunohistochemistry revealed neutrophil,...
We developed a molecular sorter that operates without external power or control by integrating the microtubule-based, biological motor kinesin into microfluidic channel network to sort, transport, and concentrate molecules. In our devices, functionalized microtubules capture analyte molecules are steered along kinesin-coated microchannel tracks toward collector structure, concentrated, trapped. Using fluorescent nanoliter sample volumes, we demonstrated 14 fM sensitivity, even in presence of...
Triple-negative breast cancer (TNBC), accounting for approximately 20% of cases, is a particular subtype that lacks tumor-specific targets and difficult to treat due its high aggressiveness poor prognosis. Chemotherapy remains the major systemic treatment TNBC. However, applicability efficacy in clinic are usually concerning lack targeting, adverse side effects, occurrence multidrug resistance, suggesting development effective therapeutics still highly demanded nowadays. In this study, an...
A 14-year-old girl, who had been suffering from intermittent fevers for 2 months, developed painful erythematous plaques on the lower extremities. Laboratory data revealed elevated C-reactive protein, lactate dehydrogenase, and aspartate aminotransferase/alanine aminotransferase (AST/ALT). Blood urine cultures were negative. CT showed hepatosplenomegaly. F-18 FDG PET multiple patchy uptakes subcutaneous surfaces residing mainly at trunk The images clinical manifestations appeared...
The incorporation of plasmonic metal nanostructures into semiconducting chalcogenides in the form core-shell structures provides a promising approach to enhancing performance photodetectors. In this study, we combined Au nanoparticles with newly developed copper-based Cu
Abstract The genome of one Taiwanese severe acute respiratory syndrome-associated coronavirus (SARS-CoV) strain (TW1) was 29,729 nt in length. Viral RNA may persist for some time patients who seroconvert, and lack an antibody response (immunoglobulin G) to SARS-CoV >21 days after illness onset. An upsurge associated with the aggravation failure.
As developments of modern societies, an on-field and personalized diagnosis has become important for disease prevention proper treatment. To address this need, in work, a polysilicon nanowire (poly-Si NW) based biosensor system-on-chip (bio-SSoC) is designed fabricated by 0.35 μm 2-Poly-4-Metal (2P4M) complementary metal-oxide-semiconductor (CMOS) process provided commercialized semiconductor foundry. Because the advantages CMOS (SoC) technologies, poly-Si NW integrated with chopper...
We report a microfluidic device integrating dual CMOS polysilicon nanowire sensors (MINS) for on-chip whole blood processing and simultaneous detection of Hb HbA1c.
This paper presents a highly-integrated DNA detection SoC, where several kinds of cantilever sensors, readout circuit, an MCU, voltage regulators, and wireless transceiver, are integrated monolithically in 0.35 μm CMOS Bio-MEMS process. The cantilever-based biosensors with embedded piezoresistors aim to transduce hybridization into resistance variation without cumbersome labeling To improve sensitivity for low concentration use, oscillator-based self-calibrated circuit high precision is...
Statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, are used to reduce cholesterol biosynthesis in the liver. Accordingly, statins regulate nitric oxide (NO) and glutamate metabolism, inflammation, angiogenesis, immunity endothelial progenitor cells (EPCs) functions. The function EPCs regulated by stromal cell-derived factor 1 (SDF-1), vascular growth (VEGF), transforming β (TGF-β), etc. Even though pharmacologic mechanisms which affect neovasculogenesis...
Graphene-based supercapacitors have gained significant attention due to their exceptional energy storage capabilities. Despite numerous research efforts trying improve the performance, challenge of experimentally elucidating nanoscale-interface molecular characteristics still needs be tackled for device optimizations in commercial applications. To address this, we conducted a series experiments using substrate-free graphene field-effect transistors (SF-GFETs) and oxide-supported (OS-GFETs)...
Background: This study evaluates the feasibility of Apple Vision Pro goggles as an augmented reality (AR) surgical navigation tool for laparoscopic-assisted ultrasound-guided radiofrequency ablation (RFA) liver tumors. Traditional RFA is effective but challenging due to integration multiple imaging modalities. Purpose: The primary aim this research assess how can enhance process during RFA, improving tumor localization and overall effectiveness procedure. Research Design: A design was used...