A5050779679- Pulsars and Gravitational Waves Research
- Geophysics and Gravity Measurements
- Radio Astronomy Observations and Technology
- Gamma-ray bursts and supernovae
- Visual perception and processing mechanisms
- Astrophysics and Cosmic Phenomena
- Superconducting Materials and Applications
- Astrophysical Phenomena and Observations
- Stellar, planetary, and galactic studies
- Speech and Audio Processing
- Advanced Adaptive Filtering Techniques
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Hereditary Neurological Disorders
- Blind Source Separation Techniques
- Neurological diseases and metabolism
- Cosmology and Gravitation Theories
- Genetic Neurodegenerative Diseases
- Trace Elements in Health
- Prion Diseases and Protein Misfolding
- Advanced Frequency and Time Standards
- Alzheimer's disease research and treatments
- Color Science and Applications
- Neural dynamics and brain function
- Image and Signal Denoising Methods
University of Manchester
2011-2025
Max Planck Institute for Radio Astronomy
2011-2025
Max Planck Society
1997-2015
Miami University
2010-2013
University of Göttingen
2001-2010
University of Illinois Urbana-Champaign
2002-2008
Universitätsmedizin Göttingen
2005
Daimler (Germany)
1998
Max Planck Research Unit for Enzymology of Protein Folding
1998
Lewy bodies, the pathological hallmark of dementia with bodies (DLB), are large juxtanuclear inclusions aggregated alpha-synuclein. However, small number cortical relative to total neuron count does not correlate extent cognitive impairment. In contrast dopaminergic neurons in Parkinson's disease, nerve cell loss is usually less prevalent cortex DLB, suggesting a different mechanism neurodegeneration. Because antibodies used for immunodetection per se do generally differentiate from...
The rotation of more than 700 pulsars has been monitored using the 76-m Lovell Telescope at Jodrell Bank. Here we report on a new search for glitches in observations, revealing 128 63 pulsars. Combining these data with those already published present database containing 315 102 was used to study glitch activity among pulsar population, finding that it peaks characteristic age tau_c ~ 10kyr and decreases longer values tau_c, disappearing objects > 20Myr. is also smaller very young (tau_c <~...
We present the results of a search for continuous gravitational wave signals (CGWs) in second data release (DR2) European Pulsar Timing Array (EPTA) Collaboration. The most significant candidate event from this has frequency 4–5 nHz. Such signal could be generated by supermassive black hole binary (SMBHB) local Universe. follow-up analysis using both Bayesian and frequentist methods. gives Bayes factor 4 favour presence CGW over common uncorrelated noise process. In contrast, estimates...
The prion protein is known to be a copper-binding protein, but affinity and stoichiometry data for the full-length at physiological pH of 7 were lacking. Furthermore, it was unknown whether only highly flexible N-terminal segment with its octarepeat region involved in copper binding or structured C-terminal domain also involved. Therefore we systematically investigated PrP23–231 different N- fragments using electrospray ionization mass spectrometry fluorescence spectroscopy. Our indicate...
Benefitting from the unequaled precision of pulsar timing technique, binary pulsars are important testbeds gravity theories, providing some tightest bounds on alternative theories gravity. One class well-motivated scalar-tensor gravity, predict large deviations general relativity for neutron stars through a nonperturbative phenomenon known as spontaneous scalarization. This effect, which cannot be tested in Solar System, can now tightly constrained using latest results set 7 (PSRs...
We present the results of a search for continuous gravitational wave signals (CGWs) in second data release (DR2) European Pulsar Timing Array (EPTA) collaboration. The most significant candidate event from this has frequency 4-5 nHz. Such signal could be generated by supermassive black hole binary (SMBHB) local Universe. follow-up analysis using both Bayesian and frequentist methods. gives Bayes factor 4 favor presence CGW over common uncorrelated noise process, while estimates p-value to...
We present results on the identification and molecular characterization of conformers with secondary cis amide peptide bonds for a number oligopeptides containing tyrosine phenylalanine in aqueous solution. Employing 1H NMR techniques, adjacent to aromatic amino acid were found generate isomer population ranging from 0.1% 1% dependence chain length ionization state peptide. The rate constant trans → interconversion zwitterionic Ala-Tyr was 2.4 × 10-3 s-1 at 298 K thus range typical imidic...
Direction finding of more sources than sensors is appealing in situations with small sensor arrays. Potential applications include surveillance, teleconferencing, and auditory scene analysis for hearing aids. A new technique time-frequency-sparse sources, such as speech vehicle sounds, uses a coherence test to identify low-rank time-frequency bins. These bins are processed one two ways: (1) narrowband spatial spectrum estimation at each bin followed by summation directional spectra across...
We report on the discovery of four millisecond pulsars (MSPs) in High Time Resolution Universe (HTRU) pulsar survey being conducted at Parkes 64-m radio telescope. All MSPs are binary systems and likely to have white dwarf companions. In addition, we present updated timing solutions for 12 previously published HTRU MSPs, revealing new observational parameters such as five proper motion measurements significant temporal dispersion measure variations PSR J1017-7156. discuss case J1801-3210,...
Pulsar timing srray (PTA) collaborations gather high-precision measurements of pulsars, with the aim detecting gravitational wave (GW) signals. A major challenge lies in identification and characterisation different sources noise that may hamper their sensitivity to GWs. The presence time-correlated resembles target signal might give rise degeneracies can directly impact detection statistics. In this work, we focus on covariance exists between a ‘chromatic’ dispersion measure (DM) an...
Millisecond pulsars (MSPs) in binary systems are precise laboratories for tests of gravity and the physics dense matter. Their orbits can show relativistic effects that provide a measurement neutron star mass included timing array experiments search gravitational waves. Neutron measurements key to eventually solving equation state these be obtained by measure Shapiro delay if orbit is viewed near edge-on. Here we report on noise analysis five MSPs observed with MeerKAT radio telescope: PSRs...
Abstract Radio searches for single pulses provide the opportunity to discover one-off events, fast transients and some pulsars that might otherwise be missed by conventional periodicity searches. The MeerTRAP real-time search pipeline operates commensally observations with MeerKAT telescope. Here, we report on 26 new Galactic radio transients, mostly rotating (RRATs) also detection of one RRAT two were independently discovered other surveys. dispersion measures sources marginally exceed...
We present the MeerKAT discovery and MeerLICHT contemporaneous optical observations of Fast Radio Burst (FRB) 20230808F, which was found to have a dispersion measure $\mathrm{DM}=653.2\pm0.4\mathrm{\,pc\,cm^{-3}}$. FRB 20230808F has scattering timescale $\tau_{s}=3.1\pm0.1\,\mathrm{ms}$ at $1563.6$ MHz, rotation $\mathrm{RM}=169.4\pm0.2\,\mathrm{rad\,m^{-2}}$, radio fluence $F_{\mathrm{radio}}=1.72\pm0.01\,\mathrm{Jy\,ms}$. find no counterpart in time immediately after FRB, nor three months...
Prion diseases are caused by the aggregation of native alpha-helical prion protein PrP(C) into its pathological beta-sheet-rich isoform PrP(Sc). In current models PrP(Sc), helix1 is assumed to be preferentially converted beta-sheet during PrP(C). This was supported NMR structure since, in contrast isolated helix1, helix2 and helix3 connected a small loop additionally stabilized an interhelical disulfide bond. However, extremely hydrophilic has high helix propensity. prompted us investigate...
Wallerian degeneration in peripheral nerves occurs after a traumatic insult when the distal nerve part degenerates while macrophages enter stump and remove accruing debris by phagozytosis. We used an experimental model to investigate effect of either absence or over-expression alpha-synuclein (alpha-syn) transecting sciatic mice. alpha-Synuclein is major component Lewy bodies its aggregation results premature destruction cells. It has also been found present different but role axon remains...
Since their discovery in the late 1960's population of known neutron stars has grown to ∼2500.This sample yielded many surprises and demonstrated that observational properties are remarkably diverse.The surveys will be performed with SKA produce a further tenfold increase number Galactic known.Moreover, SKA's broad spectral coverage, sub-arraying multi-beaming capabilities allow us characterise these sources unprecedented efficiency, turn enabling giant leap understanding properties.We...
In some applications, it is of interest to localize more sources than number sensors. For a class nonstationary wideband that exhibit onset-offset-like behavior, we develop statistical test choose desirable time-frequency bins where apply the MUSIC or minimum variance estimators. Finally, fuse localization results across those bins. Experimental with pair real hearing-aid microphones indicate successful four speech sources.
Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy are caused by alpha-synuclein aggregates. At present, there is no good biochemical method defining aggregates formed in vivo versus oligomers as a means to investigate aggregation its mechanisms of neurodegeneration. A simple method, therefore, for the selective sensitive detection suited screening purposes would be useful. Since contrast prions proper Western blot analysis difficult, we developed protein...
Abstract The prion protein (PrP C ) has a primary role in the pathogenesis of transmissible spongiform encephalopathies. Here we analysed detail effect recombinant PrP and N‐ C‐terminal fragments on whole‐cell current amplitude through voltage‐gated calcium channels (VGCCs) cultured wild‐type cerebellar granule cells. With application full‐length (50–500 n m ), highly significant reduction was observed dose‐dependent manner. Amplitude abolished when cells were pre‐incubated with nifedipine,...
ABSTRACT In an accompanying publication, the MeerKAT Pulsar Timing Array (MPTA) Collaboration reports tentative evidence for presence of a stochastic gravitational wave background, following observations similar signals from European and Indian Arrays, North American Nanohertz Observatory Gravitational Waves, Parkes Array, Chinese Array. If such background signal originates population inspiraling supermassive black hole binaries, may be anisotropically distributed in sky. this paper, we...