A5052013349- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Acute Kidney Injury Research
- Renal Transplantation Outcomes and Treatments
- Complement system in diseases
- Long-Term Effects of COVID-19
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Muscle and Compartmental Disorders
- COVID-19 Impact on Reproduction
- SARS-CoV-2 detection and testing
- Mechanical Circulatory Support Devices
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Dermatological and COVID-19 studies
- Potassium and Related Disorders
- Adenosine and Purinergic Signaling
- Retinal and Optic Conditions
- Magnesium in Health and Disease
- Antibiotics Pharmacokinetics and Efficacy
- Hemoglobinopathies and Related Disorders
- Parathyroid Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Renal function and acid-base balance
Cincinnati Children's Hospital Medical Center
2014-2025
University of Cincinnati Medical Center
2020-2025
University of Cincinnati
2019-2024
Pediatric Nephrology of Alabama
2020
University of Massachusetts Chan Medical School
2000
Institut Gustave Roussy
1991
Host proteases have been suggested to be crucial for dissemination of MERS, SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution membrane versus intracellular remains controversial. Transmembrane serine protease 2 (TMPRSS2) is regarded as one main implicated in coronavirus S protein priming, an important step binding angiotensin-converting enzyme (ACE2) receptor before cell entry.We developed a cell-based assay identify TMPRSS2 inhibitors. Inhibitory activity was established...
Since previous evidence has demonstrated that red blood cell distribution width (RDW) may be a useful prognostic parameter in many critical illnesses and infectious diseases, we investigated the utility of RDW for monitoring patients with coronavirus disease 2019 (COVID-19). The study population consisted 49 COVID-19 patients, including 16 (32.6%) severe illness, 12 (24.5%) acute kidney injury (AKI), 8 (16.3%) requiring renal replacement therapy (RRT). predictive value tests, performed...
Abstract Introduction Severe COVID‐19 is often compounded by a prothrombotic state that associated with poor outcomes. In this investigation, we aimed to evaluate ADAMTS13 activity, von Willebrand factor level (VWF:Ag), and the corresponding activity/VWF:Ag ratio, in patients for associations disease progression acute kidney injury (AKI). Methods Patients presenting emergency department (ED) were enrolled prospective, observational study. activity VWF:Ag measured at index ED visit. The...
Abstract Objectives Severe coronavirus disease 2019 (COVID-19) is associated with a dysregulated immune state. While research has focused on the hyperinflammation, little been performed compensatory anti-inflammatory response. The aim of this study was to evaluate cytokine response COVID-19, by assessing interleukin-10 (IL-10) and IL-10/lymphocyte count ratio their association outcomes. Methods Adult patients presenting emergency department (ED) laboratory-confirmed COVID-19 were recruited....
Abstract Host proteases have been suggested to be crucial for dissemination of MERS, SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution membrane versus intracellular remains controversial. Transmembrane serine protease 2 (TMPRSS2) is regarded as one main implicated in coronavirus S protein priming, an important step binding angiotensin-converting enzyme (ACE2) receptor before cell entry. The cellular location where priming occurs debatable, therefore hampering development...
Complement system hyperactivation has been proposed as a potential driver of adverse outcomes in severe acute respiratory syndrome coronavirus 2 infected patients, given prior research complement deposits found tissue and blood samples, well evidence clinical improvement with anticomplement therapy. Its role augmenting thrombotic microangiopathy mediated organ damage also implicated disease 2019 (COVID-19). This study aimed to examine associations between parameters progression COVID-19...
Introduction: Neutrophil extracellular traps (NETs) release (i.e., NETosis) has been recently implicated in the pathomechanism underlying severe end-organ damage Coronavirus Disease 2019 (COVID-19) and could present a novel therapeutic target. We aimed to determine whether circulating levels of cell-free DNA (cfDNA), surrogate for NETosis, may be associated with development acute kidney injury (AKI), major contributor poor outcomes mortality COVID-19. Methods: Blood samples were collected...
Transplantation-associated thrombotic microangiopathy (TA-TMA) can range from a self-limiting condition to lethal transplantation complication. It is important identify TA-TMA patients at risk for severe multiorgan endothelial injury implement targeted therapies in timely manner. Current therapeutic approaches with complement blockade have improved survival markedly high-risk patients, yet one-third of these respond inadequately eculizumab therapy. Poor response may indicate that substantial...
Abstract Background Several studies have investigated long-term kidney outcomes in survivors of Wilms tumor (WT). However, many small sample sizes, and there is a wide variation reported outcomes. The aim this study to investigate the WT (S-WT), including those patients considered be at high risk for poor outcomes, using updated estimated glomerular filtration rate (eGFR) equations. Methods This was retrospective chart review 64 treated single pediatric center. Patients were off treatment 5...