Globally, gastric ulcer is a vital health hazard for human. Rabdosia inflexa (RI) has been used in traditional medicine inflammatory diseases. The present study aimed to investigate the protective effect and related molecular mechanism of RI using lipopolysaccharide (LPS)-induced inflammation RAW 246.7 cells HCl/EtOH-induced mice. We applied 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), nitric oxide (NO), reactive oxygen species (ROS), histopathology, malondialdehyde...

Agastache rugosa is used as a Korean traditional medicine to treat gastric diseases. However, the active ingredients and pharmacological targets of A. are unknown. In this study, we aimed reveal effects on gastritis by combining mice model network pharmacology method. The macrophage gastritis-induced models were evaluate rugosa. results show that relieved mucosal damage induced HCl/EtOH in vivo. Network analysis identified 99 components rugosa; six selected through systematic screening, five...

Scutellaria baicalensis Georgi and Raphanus Sativus Linne herbal mixture (SRE) is a Chinese medicine. In this study, we aimed to evaluate the therapeutic efficacy of SRE as an active ingredient for 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) predict underlying mechanisms involved pathways using network pharmacological analysis. Treatment with accelerated development AD-like lesions, improving thickness edema epidermis. Moreover, administering mice suppressed immunoglobulin...

ABSTRACT Radiation therapy has been used to treat cancer; however, the associated DNA damage and adverse effects in surrounding tissues remain major concerns. In radiation injury, several natural remedies can effectively relieve symptoms with minimal side effects. Cicadidae Periostracum (CP, also called “Sun‐Tae”) is cast‐off shell of Cryptotympana pustulata Fabricius traditionally for pharmacological actions. This study investigated protective CP water extract (CPE) on irradiated testicular...

Sodium arsenite (NaAsO2) has been recognized as a worldwide health concern. Hydrangea macrophylla (HM) is used traditional Chinese medicine possessing antioxidant activities. The study was performed to investigate the therapeutic role and underlying molecular mechanism of HM on NaAsO2-induced toxicity in human liver cancer (HepG2) cells mice. hepatoprotective HepG2 assessed by using 3-(4,5-dimethylthiazol-2-Yl)-2,5-diphenyltetrazolium bromide (MTT), reactive oxygen species (ROS), lactate...

Silica dioxide nanoparticles (SiONPs) have been applied to several fields, such as drug delivery and gene therapy. However, SiONPs are a constituent of fine dust can induce excessive inflammatory responses in the lungs via airways. Silibinin, major component silymarin, has known for its anti-oxidant anti-inflammatory effects. In present study, we explored protective effects silibinin against SiONPs-induced airway inflammation underlying mechanism action, focusing on thioredoxin-interacting...

Abstract Protaetia brevitarsis seulensis is an animal‐based medicine used traditionally in China, Japan, and Korea to treat hepatic disorders; it has been shown possess various pharmacological effects such as antibacterial antioxidant activities. In this study, we investigated the of P . on a testosterone‐induced benign prostatic hyperplasia (BPH) rat model. To establish BPH model, animals were administered subcutaneous injection testosterone daily for 28 days. was by oral gavage at doses...

Anethum graveolens L. (dill seeds) are important medicinal and functional foods in Europe central south Asia, often used as a seasoning daily diets. seeds (AGS) to treat indigestion have shown physiological activities such those against hypoglycemia gastroesophageal disease. This study explored the protective effects of AGS extract on mucosal damages inflammation reflux esophagitis rats. inhibited cellular including NO production expression inflammatory proteins (iNOS COX2 etc.), cytokines...

Abstract The larvae of Protaetia brevitarsis seulensis have been used as a food ingredient and are known for their nutritional value anti‐inflammatory properties. However, whether P. demonstrate protective effects against radiation‐induced testicular injury has not investigated. In this study, the an aqueous extract (PBE) were tested. Male C57BL/6 mice administered PBE (5 or 10 mg/kg) orally 14 days before exposure to focal pelvic irradiation. Histopathological examinations conducted at 8 h...

As a traditional medicine with potential antioxidant effects, Tenodera angustipennis egg cases (Mantidis ootheca) are source of new bioactive substances. Herein, three N-acetyldopamine derivatives, namely, (+)-tenoderin A (1a), (−)-tenoderin (1b), and tenoderin B (2), along thirteen known compounds (3–15), were isolated from 70% EtOH extract T. cases. Compound 1 was as racemic mixture, two enantiomers (1a 1b) successfully separated by chiral-phase preparative HPLC. The chemical structures...

Reflux esophagitis (RE) is a gastrointestinal disease caused by the reflux of gastric acid and stomach contents, it leads to esophageal damage. Therefore, necessary study improvement damage on RE-induced model. The present was accomplished demonstrate protective effects dichloromethane fraction Geranium koreanum (DGK) plant in an acute RE rat First, we examined potential anti-inflammatory various fractions measured cell cytotoxicity, morphological changes nitric oxide (NO) production...

The effect on the antioxidant activity and Nitric Oxide production inhibitory of Taraxacum has not been known. Therefore, phenolics flavonoid contents were investigated from ethanol extracts five differ-ent species. results showed that, among Taraxacum, T. hallaisanensis contains highest total phe-nolic contents. When was measured by DPPH, ABTS reducing power activity, free radical scavenging also However, mea-surement CCK-8 assay in Raw264.7 cells indicated that species have no cell...

Geranium koreanum (GK) is an indigenous Chinese herbal medicine widely used for the treatment of various inflammation and liver disorders. However, exact mechanism action GK remains unknown. This study aimed to investigate protective effect related molecular on NaAsO 2 -induced cytotoxicity in HepG2 cells damage mice. The cytoprotective role was assessed using MTT assay. Oxidative stress lactate dehydrogenase levels were measured with ROS LDH Histopathology serum enzymes estimated. evaluated...

Gekko gecko is used as a traditional medicine for various diseases including respiratory disorders in northeast Asian countries, mainly Korea, Japan, and China.Allergic asthma chronic disease caused by an inappropriate immune response. Due to the recent spread of coronavirus 2019, interest treatment pulmonary has rapidly increased. In this study, we investigated anti-asthmatic effects G. extract (GGE) using established mouse model ovalbumin-induced asthma.To evaluate GGE, evaluated...

Scrophularia have traditionally been used as herbal medicines to treat neuritis, sore throats, and laryngitis. In particular, S. takesimensis, a Korean endemic species with restricted distribution on Ulleung Island, holds significant resource genetic value. However, its pharmacological properties not thoroughly evaluated. Thus, we provide detailed morphological characteristics genomic information for takesimensis in this study. Moreover, activity was evaluated an ovalbumin-induced asthma rat...

Late-onset hypogonadism (LOH) is an age-related disease in men characterized by decreased testosterone levels with symptoms such as libido, erectile dysfunction, and depression. Thymus quinquecostatus Celakovski (TQC) a plant used volatile oil traditional medicine, its bioactive compounds have anti-inflammatory potential. Based on this knowledge, the present study aimed to investigate effects of TQC extract (TE) LOH TM3 Leydig cells vivo aging mouse model. The aqueous T. (12.5, 25, 50 µg/mL...

Abstract Background Excessive and continuous inflammation may be the main cause of various immune system diseases. Reflux esophagitis (RE) is a common gastroesophageal reflux disease (GERD). Camellia japonica has high medicinal value long been used as traditional herbal hemostatic medicine in China Korea. The purpose this study to explore antioxidant anti-inflammatory activities CJE its protective effect on RE. Materials methods Buds from C. plants were collected mountain area Jeju, South...

Reflux esophagitis (RE) is a kind of gastroesophageal reflux disease, which an esophageal inflammatory lesion caused by the contents stomach and duodenum flowing back into esophagus. Allium hookeri plant possessing both nutritional medicinal properties. In our study, we investigated inhibition effect inflammation A. root extract (AHE) on RAW264.7 macrophage cells induced lipopolysaccharide rat models RE. The results showed that AHE significantly reduced production nitric oxide (NO) protein...

Repeated reflux of gastric acid and stomach contents into the esophagus leads to damage, including inflammation, ulcer, hemorrhage in epithelium. In this study, we aimed demonstrate ameliorating effects geraniin, a phytochemical geraniums, on damage an acute esophagitis (RE) rat model. The inflammatory geraniinwas measured by nitric oxide (NO) production pro-inflammatory protein levels lipopolysaccharide (LPS)-induced RAW 264.7 cells. To evaluate protective geraniin damaged tissue RE rats,...

Abstract Gastroesophageal reflux disease (GERD) is a globally prevalent and results from of gastric contents into the esophagus. Existing synthetic drug‐based treatments for GERD have various drawbacks including refractory symptoms, relapse, or resistance due to long‐term use may result in mucosal degeneration, polyps, osteoporosis. Semisulcospira gottschei (SE), freshwater snail, has been generally consumed as food source its excellent flavor nutritional value Korea considered therapeutic...

Asthma is a pulmonary disease induced by the inhalation of aeroallergens and subsequent inappropriate immune responses. Camellia sinensis (L.) Kuntze has been evaluated as an effective antioxidant supplement produced from bioactive compounds, including flavonoids. In this study, we aimed to determine effects extract (CE) on ovalbumin-induced allergic asthma. The components CE were analyzed using high-performance liquid chromatography (HPLC) chromatogram patterns, asthmatic animal models via...

Gastroesophageal reflux disease (GERD) is a that stomach contents continually refluxing into esophagus causes symptoms and/or complications. The study was working to find natural plant extracts with good effects and small side treat esophagitis (RE). anti‐inflammatory of hexane extract Magnolia sieboldii (MsHE) were conducted on lipopolysaccharide (LPS)‐stimulated RAW 264.7 macrophage cells. ameliorative MsHE esophageal damage in rats induced by gastric acid explored vivo. results showed...