A5030971684- Nanoplatforms for cancer theranostics
- Photonic and Optical Devices
- Optical Coherence Tomography Applications
- Photoreceptor and optogenetics research
- Click Chemistry and Applications
- Photosynthetic Processes and Mechanisms
- Electron and X-Ray Spectroscopy Techniques
- Advanced Fluorescence Microscopy Techniques
- Photodynamic Therapy Research Studies
- Molecular Junctions and Nanostructures
- Spectroscopy and Quantum Chemical Studies
- Quantum Dots Synthesis And Properties
- Luminescence and Fluorescent Materials
- Random lasers and scattering media
- Various Chemistry Research Topics
- Magnetic and Electromagnetic Effects
- Chalcogenide Semiconductor Thin Films
- Nanocluster Synthesis and Applications
- Particle Accelerators and Free-Electron Lasers
- Advanced Optical Sensing Technologies
- Advanced Surface Polishing Techniques
- Plant nutrient uptake and metabolism
- Microbial Metabolites in Food Biotechnology
- Advanced X-ray Imaging Techniques
- Integrated Circuits and Semiconductor Failure Analysis
University of California, Los Angeles
2019-2024
Stanford Synchrotron Radiation Lightsource
2024
SLAC National Accelerator Laboratory
2024
Fermi National Accelerator Laboratory
2024
Abstract Natural photosystems couple light harvesting to charge separation using a ‘special pair’ of chlorophyll molecules that accepts excitation energy from the antenna and initiates an electron-transfer cascade. To investigate photophysics special pairs independently complexities native photosynthetic proteins, as first step toward creating synthetic for new conversion technologies, we designed C 2 -symmetric proteins hold two in closely juxtaposed arrangements. X-ray crystallography...
The design of bright short-wave infrared fluorophores remains a grand challenge. Here we investigate the impact deuteration on properties in series heptamethine dyes, absorption which spans near-infrared and SWIR regions. We demonstrate that it is generally applicable strategy leads to enhanced quantum yields fluorescence, longer-lived singlet excited states suppressed rates non-radiative deactivation processes.
We describe and implement an interferometric approach to decay-associated photoluminescence spectroscopy, which we term Fourier spectroscopy (DAFS). In DAFS, the emitted photon stream from a substrate passes through variable path length Mach-Zehnder interferometer prior detection timing. The encodes spectral information in intensity measured at each detector enabling simultaneous temporal resolution. detail several advantages of including wavelength-range insensitivity, drift-noise...
The total photon economy of a molecule/material is measure how light input converted to and heat output across energies timescales. We describe technique, Fluorescent Optical Cycling (FOC), which allows for simultaneous observation prompt delayed emission during after multiple pulsed excitation, ultimately granting access multi-state photophysical rates. exercise control over the excitation pulse train, us “optically shelve” long-lived intermediate states without use diode or flashlamp...
We demonstrate the preparation of mesoscale semiconductor (II–VI) nanoplatelets (NPLs) for first time using colloidal seeded growth. These are quantum-confined and atomically precise but grown to a length scale compatible with conventional optical imaging microscopic manipulation (even reaching >1 μm2) offering an opportunity bridge application space between nanocrystals two-dimensional (2D) materials. Using CdTe as model system, we develop growth procedure, show parameters that control...
The total photon economy of a chromophore molecular species represents study how absorbed photons partition among various electronic states and ultimately dissipate their excited energy into the environment.
Abstract Using a tri-coincident cryogenic FIB-SEM-LM system, we identify an interferometric optical response that can be used for targeting lamella production to fluorescently labelled structures with accuracy beyond the diffraction limit. We demonstrate approach using synthetic samples of fluorescent beads embedded in micron-scale droplets water. then apply capture virions inside host cells. Successful is confirmed by electron tomography revealing clusters intracellular vesicles.
Short-wave infrared region (SWIR; 900-2000 nm) enables in vivo bioimaging with unrivaled spatial and temporal resolution, but its full potential is locked behind the lack of highly emissive organic fluorophores. Their design remains a grand challenge understanding structure-property relationship key to their rational design. Here we investigate effects deuteration on photophysical properties series heptamethine (Cy7) dyes bearing different terminal heterocycles, absorption which spans...
We demonstrate a method for separating and resolving the dynamics of multiple emitters without use conventional filters. By directing photon emission through fixed path-length imbalanced Mach–Zehnder interferometer, we interferometrically cancel (or enhance) certain spectral signatures corresponding to one emissive species. Our approach, Spectrally selective Time-resolved Emission Fourier-filtering (STEF), leverages detection subtraction both outputs tuned which can be combined with...
<title>Abstract</title> Natural photosystems couple light harvesting to charge separation using a “special pair” of chlorophyll molecules that accepts excitation energy from the antenna and initiates an electron-transfer cascade. To investigate photophysics special pairs independent complexities native photosynthetic proteins, as first step towards synthetic for new conversion technologies, we designed C<sub>2</sub>-symmetric proteins precisely position dimers. X-ray crystallography shows...
Short-wave infrared region (SWIR; 900-2000 nm) enables in vivo bioimaging with unrivaled spatial and temporal resolution, but its full potential is locked behind the lack of highly emissive organic fluorophores. Their design remains a grand challenge understanding structure-property relationship key to their rational design. Here we investigate effects deuteration on photophysical properties series heptamethine (Cy7) dyes bearing different terminal heterocycles, absorption which spans...
Colloidally grown (II-VI) semiconductor nanoplatelets display significantly smaller lateral dimensions than their mechanically exfoliated 2D van der Waal (vdW) counterparts. Here, we show that a seeded growth procedure allows us to extend the area of atomically precise mesoscale (>1 μm^2). Using CdTe as model system, optimize reaction parameters expand variety with different thickness and compositions. In situ spectroscopy results demonstrate large NPLs grow through mechanism ripening...
In this manuscript we demonstrate that directing the emitted photon stream from a fluorescent sample through fixed path-length imbalanced Mach-Zehnder interferometer allows us to separate and resolve dynamics of different emitters without use filtering optics. Our method, Spectrallyselective Time-resolved Emission Fourier-filtering (STEF) takes advantage careful selection position where one signal can be canceled (or enhanced) due its unique spectral characteristics. STEF is straightforward...
In this manuscript we demonstrate that directing the emitted photon stream from a fluorescent sample through fixed path-length imbalanced Mach-Zehnder interferometer allows us to separate and resolve dynamics of different emitters without use filtering optics. Our method, Spectrallyselective Time-resolved Emission Fourier-filtering (STEF) takes advantage careful selection position where one signal can be canceled (or enhanced) due its unique spectral characteristics. STEF is straightforward...