A5081185763- Tuberculosis Research and Epidemiology
- RNA and protein synthesis mechanisms
- Microbial Natural Products and Biosynthesis
- Mycobacterium research and diagnosis
- Trace Elements in Health
- Oxidative Organic Chemistry Reactions
- Bioactive Compounds and Antitumor Agents
- Antibiotic Resistance in Bacteria
National Institute of Immunology
2021-2022
Mycobacterium tuberculosis (Mtb) endures a combination of metal scarcity and toxicity throughout the human infection cycle, contributing to complex clinical manifestations. Pathogens counteract this paradoxical dysmetallostasis by producing specialized trafficking systems. Capture extracellular siderophores is widely accepted mode iron acquisition, Mtb iron-chelating siderophores, mycobactin, have been known since 1965. Currently, it not whether produces zinc scavenging molecules. Here, we...
Type III polyketide synthases (PKSs) found across
Abstract Tuberculosis (TB) patients suffer from progressive and debilitating loss of muscle mass function, referred to as cachexia. Though a multifactorial condition, cachexia in cancer is promoted by systemic zinc redistribution accumulation muscles. Clinical studies with TB indeed show dyshomeostasis. We therefore set out understand mechanisms which Mycobacterium tuberculosis (Mtb) govern metallostasis at the host-pathogen interface. Here, we report novel metallophore Mtb that restores...