A5000691345- Urological Disorders and Treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sexual Differentiation and Disorders
- Antifungal resistance and susceptibility
- Probiotics and Fermented Foods
- Microbial Metabolites in Food Biotechnology
Universidade Estadual de Campinas (UNICAMP)
2020-2022
Abstract Ovotesticular disorders of sex development (OT‐DSD) are characterized by ovarian follicles and seminiferous tubules in the same individual, with a wide range atypical genitalia. We report on two sibs genitalia SRY ‐negative 46,XX DSD, OT‐DSD was confirmed only boy, while girl had bilateral ovaries. Chromosome microarray analysis (CMA) showed 737‐kb duplication at Xq27.1 including entire SOX3 gene both sibs, which quantitative real time PCR. Also, X chromosome inactivation assay...
Auxotrophic mutants were obtained by exposing Candida fennica FTPT/CCT-8903 to ultraviolet light and treating the cells with nystatin in an enrichment procedure. The used for protoplast fusion. highest regeneration frequency was when treated 10 mg NovoZym 234/mL presence of 0.8 M KCl 60 min. Fusion range 5.84 × −5 7.2 . Five prototrophic hybrid colonies, designated S9, S15, S17, S18, S25, isolated, their DNA contents measured. These measurements indicated that S17 is haploid, S9 S18 are...
Abstract Ovotesticular disorder of sex development (OT-DSD) is a rare condition characterized by coexistence ovarian and testicular parenchyma, in separate gonads or the same gonad (ovotestis), individuals with variable degrees genital ambiguity. Karyotype may be 46,XX (60%), 46,XY (10%), there chromosomes abnormalities, including mosaicism, chimerism structural anomalies (30%). A genetic origin identified some subjects normal XX XY karyotype, but most cases are unknown origin. Apparently...