A5033388528- Glioma Diagnosis and Treatment
- Periodontal Regeneration and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Acute Myeloid Leukemia Research
- Dental Implant Techniques and Outcomes
- Circular RNAs in diseases
- Renal and related cancers
- Hematopoietic Stem Cell Transplantation
- RNA Research and Splicing
- Oral and Maxillofacial Pathology
Princess Margaret Cancer Centre
2019-2021
University Health Network
2019-2021
Diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain tumors for which there is currently no effective treatment. Some of these combine gain-of-function mutations in ACVR1, PIK3CA, and histone H3-encoding genes. The oncogenic mechanisms action ACVR1 unknown. Using mouse models, we demonstrate that Acvr1
The purpose of this study is to evaluate differences in marginal bone level (MBL) and survival rates implants (ISR) placed lateral-window sinus floor elevation (LSFE) sites compared other sites. Patient with a history LSFE following implant placement were identified. Clinical radiographic data was collected by 2 calibrated examiners divided into three cohorts for the analysis, including (1) LSFE-grafted sinus, (2) maxilla at than grafted (3) mandible. ISR MBL recorded calculated. potential...
Lateral-window sinus floor elevation (LSFE) is a reliable procedure to reconstruct the posterior maxilla for implant therapy. This retrospective study aimed investigate risk factors associated with Schneiderian membrane perforation (SMP) occurrence during LSFE and longitudinal regenerative outcomes following up 9 years.Patients who had between 2010 2019 were included. All demographic surgical-related data retrieved from existing electronic health records. Radiographs used evaluate vertical...
In order to sustain proficient life-long hematopoiesis, hematopoietic stem cells (HSCs) must possess robust mechanisms preserve their quiescence and genome integrity. DNA-damaging stress can perturb HSC homeostasis by affecting survival, self-renewal, differentiation. Ablation of the kinase ataxia telangiectasia mutated (ATM), a master regulator DNA damage response, impairs fitness. Paradoxically, we show here that loss single allele Atm enhances functionality in mice. To explain this...
Diffuse Intrinsic Pontine Gliomas (DIPGs) are aggressive pediatric brain tumors for which there is currently no effective treatment. Most DIPGs driven by mutations in histone H3-encoding genes, and a subset of these also carry gain-of-function ACVR1, encodes BMP type I receptor. The oncogenic mechanisms action ACVR1 unknown. Here, we generate novel conditional knock-in mouse model the most common mutation driving DIPG (Acvr1G328V). Glial cells carrying hyperactivate signaling, exhibit...