A5046517266- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Sarcoidosis and Beryllium Toxicity Research
- Immune Cell Function and Interaction
- RNA modifications and cancer
Karolinska Institutet
2022-2024
Tuberculosis (TB) and sarcoidosis are both granulomatous diseases. Here, we compared the immunological microenvironments of granulomas from TB patients using in situ sequencing (ISS) transcriptomic analysis multiplexed immunolabeling tissue sections. lesions consisted large necrotic cellular granulomas, whereas “multifocal” with macrophages or epitheloid cell core a T-cell rim were observed samples. The was surrounded by encircled dense layer. Within layer, compact B-cell aggregates most...
Abstract The hypoxia-inducible factors (HIFs) regulate the main transcriptional pathway of response to hypoxia in T cells and are negatively regulated by von Hippel-Lindau factor (VHL). But role HIFs regulation CD4 cell responses during infection with M. tuberculosis isn’t well understood. Here we show that mice lacking VHL ( Vhl cKO ) highly susceptible , which is associated a low accumulation mycobacteria-specific lungs display reduced proliferation, altered differentiation enhanced...