A5036463192- Ion channel regulation and function
- Venomous Animal Envenomation and Studies
- Computational Drug Discovery Methods
- Bioactive Compounds and Antitumor Agents
- Nicotinic Acetylcholine Receptors Study
- Synthesis and biological activity
- Cardiac electrophysiology and arrhythmias
- Nigella sativa pharmacological applications
- thermodynamics and calorimetric analyses
- Trace Elements in Health
- SARS-CoV-2 and COVID-19 Research
- Cardiac Ischemia and Reperfusion
- Organ Transplantation Techniques and Outcomes
- Adenosine and Purinergic Signaling
- Vitamin C and Antioxidants Research
- Histone Deacetylase Inhibitors Research
- Pharmacological Effects and Toxicity Studies
- Chemical Thermodynamics and Molecular Structure
- Drug Transport and Resistance Mechanisms
- Marine Toxins and Detection Methods
- Drug Solubulity and Delivery Systems
- Marine Sponges and Natural Products
- Nuclear Receptors and Signaling
- Phytochemical Studies and Bioactivities
- Cardiovascular Effects of Exercise
Future University in Egypt
2015-2023
Ain Shams University
2020
KU Leuven
2004-2012
Alzheimer’s disease (AD) is characterized by a robust inflammatory response elicited the accumulation and deposition of amyloid-β (Aβ) within brain. Aβ induces detrimental responses through toll-like receptors (TLRs) signaling pathway. Thymoquinone (TQ), main active constituent Nigella sativa oil, has been reported several previous studies for its potent anti-inflammatory effect. The aim this study to elucidate effect TQ in improving learning memory, using rat model AD induced combination...
Obesity is a continually growing pandemic leading to many diseases that affect the overall quality of life. The widely marketed Garcinia cambogia (GC) and Raspberry ketone (RK) were used in this study. Despite their known dietetic effect, however, metabolomic/signaling pathways involved effect are not fully elucidated. Hence, our study comprehends possible trajectories combination against obesity insulin resistance addition exploring merit.Adult male Wistar rats divided into 5 groups; viz.,...
Aim: Diabetic retinopathy causes loss of vision in adults at working-age. Few therapeutic options are available for treatment diabetic retinopathy. Carbamazepine (CARB), a widely used antiepileptic drug, was recently accounted its neuroprotective effect. Nerve growth factor (NGF) activates various cascades among which, PI3K/Akt/mTOR pathway has vital action NGF-mediated neuronal differentiation and survival. This study evaluated the effect CARB retina unveiled some underlying molecular...
Hepatocellular carcinoma remains one of the most dominant malignancies worldwide. Neutraceuticals have become under focus in anticancer treatment. Resveratrol is major components Polygonum Cuspidatum and known as chemo-preventive agent. Thymoquinone potent constituents Nigella Sativa has many medicinal effects. The aim present study to investigate combined effect thymoquinone resveratrol on treatment hepatocellular cells (HepG2). We evaluated separately combination HepG2. Cell viability,...
Euryops pectinatus is a South African ornamental plant belonging to family Asteraceae. The present work evaluates the cytotoxic activity and phytochemical profile of flower extract. Metabolite profiling was performed using HPLC-PDA-ESI-MS/MS. Total phenolics flavonoids content were assessed. Cytotoxicity evaluated against 6 different cancer cell lines MTT assay. possible underlying mechanism proposed. We analyzed whether extract could overcome resistance multidrug-resistant cells for...
Tribulus terrestris saponins (TTS) have been longley used as an overall tonic and recent studies showed they influence inflammatory conditions. We examined the ameliorative effect of a commercial formula saponin-rich extract TT in model dietary obesity female rats focusing on their ability to control burden, insulin resistance (IR), adipokine expression related reproductive system pathologies. Female were fed with high fat diet (HFD) for 14 weeks launch diet-induced obesity; assigned as:...
Although dysautonomia was documented in inflammatory bowel disease, with activation of the stress-related sympathetic system, role agonists/antagonists adrenergic receptors is not conclusive. Moreover, ulcerative colitis recently linked to dementia, but potential presenilin 1(PS1)/BACE-1/beta-amyloid (Aβ) axis has been evaluated. Hence, we investigated impact mirabegron (β3-agonist) and/or carvedilol (β1/β2 antagonist) on iodoacetamide-induced emphasis novel pathomechanism PS1/BACE-1/Aβ...
The first example of a new sub-family toxins (alpha-KTx20.1) from the scorpion Tityus trivittatus was purified, sequenced and characterized physiologically. It has 29 amino acid residues, three disulfide bridges assumed to adopt cysteine-stabilized alpha/beta scaffold with pI value 8.98. sequence identities all other known alpha-KTx are less than 40%. Its effects were verified using seven different cloned K(+) channels (vertebrate Kv1.1-1.5, Shaker IR hERG) expressed in Xenopus leavis...
AimsExercise started early after myocardial infarction (MI) improves in vivo cardiac function and myofilament responsiveness to Ca2+. We investigated whether this represents partial or complete reversal of cellular remodelling.
Cardioprotective agents are compounds that provide heart protection and decrease cardiotoxicity incidence. Cardiotoxicity is a serious condition results in diminishing the heart's ability to pump blood throughout body can be developed into failure. Oxidative stress an important pathogenic event where generated reactive oxygen species (ROS) cause myocardial cellular destruction. Moreover, apoptosis, fibrosis, inflammatory cascades play major roles pathogenesis. Recently, much attention has...
OdK1 has 29 amino acids, six conserved cysteines and a pI value of 4.95. Based on multiple sequence alignments, was classified as α‐KTx 8.5. The pharmacological effects were studied different cloned K + channels (vertebrate Kv1.1‐Kv1.5 Shaker IR) expressed in Xenopus laevis oocytes. Interestingly, selectively inhibited the currents through Kv1.2 with an IC50 183 ± 3 nM but did not affect any other channels.
Molecular modeling results reported in this paper are crucial highlighting the quantitative relationship between optimized structure and computed molecular properties related to four newly synthesized uracil derivatives with promising biological potential as anticancer bioactive agents. Moreover, 5-fluorouracil (5-FU) its tautomers thiouracils studied correlated their activities. The great medical importance of these similar systems requires research on structure-activity relationships...
This research theoretically modeled the binding interaction of Sars-Cov-2 (Spike protein) utilizing molecular docking with some potential repurposed antiviral medications and two botanical products (Curcumin Quercetin). Molecular between drugs proteins reflecting pure electrostatic forces H-bond formation is complemented DFT results that shed light on electronic nature interactions. Moreover, computations provide invaluable information about drug reactivity indices calculated from energies...
Abstract Background Myocardial injury is considered as a worldwide main cause of morbidity and mortality. The present study aimed to investigate the probable cardioprotective activity naturally occurring endogenous fatty acid ester methyl palmitate (MP) against isoproterenol (ISO)-induced myocardial in rats possible underlying molecular mechanisms. was carried out two consecutive sets experiments; first set screened dose MP ISO-intoxicated rats. In second set, forty male Sprague Dawley...