Alzheimer’s disease (AD) is characterized by a robust inflammatory response elicited the accumulation and deposition of amyloid-β (Aβ) within brain. Aβ induces detrimental responses through toll-like receptors (TLRs) signaling pathway. Thymoquinone (TQ), main active constituent Nigella sativa oil, has been reported several previous studies for its potent anti-inflammatory effect. The aim this study to elucidate effect TQ in improving learning memory, using rat model AD induced combination...

Abstract Sorafenib is a potent inducer of ferroptosis used to manage hepatocellular carcinoma (HCC). The induced by sorafenib activates the p62–Keap1–Nrf2 pathway. Abnormal activation Nrf2 reduces sorafenib’s efficiency and action induces resistance. Consequently, our study tried effect novel combination Camptothecin (CPT, inhibitor) improve reduce resistance in treatment HCC. We evaluated efficacy and/or CPT using HepG2 Huh7 cell lines. MTT assay anti-proliferation effects. index (CI) dose...

Neurotransmitters are released from nerve terminals and neuroendocrine cells by calcium-dependent exocytosis of vesicles. Before fusion, vesicles docked to the plasma membrane rendered release competent through a process called priming. Electrophysiological methods such as capacitance measurements carbon fiber amperometry accurately measure fusion step with high time resolution but provide only indirect information about priming docking. Total internal reflection fluorescence microscopy...

Thymoquinone (TQ), the main active ingredient in Nigella sativa oil, exhibits various bioactivities. This study aimed to investigate effect of TQ on neurobehavioral and neuropathological alterations induced by aluminum trichloride (AlCl3) D-galactose (D-gal)-in male rats explore related mechanisms.D-gal (60 mg/kg day) AlCl3 (10 were given intraperitoneally (i.p.) once daily for 42 days after 4 weeks was concomitantly administered intragastrically (i.g.) (20 mg/kg/day) 14 days. Then, memory...

Osteoporosis is most prevalent in postmenopausal women and a widespread condition that impacts millions of individuals worldwide. A decrease bone mineral density elevated susceptibility to fractures as result architecture deterioration are the primary attributes osteoporosis. Due challenging nature treating osteoporosis chronic condition, further research into innovative efficacious therapeutic animal models aim test these drug approaches necessary. Numerous preclinical clinical studies have...

Parkinson's disease (PD) is the second most common age-related neurodegenerative after Alzheimer's disease, characterized by loss of dopaminergic neurons in substantia nigra pars compacta, accompanied motor and nonmotor symptoms. The neuropathological hallmarks PD are well reported, but etiology still undefined; several studies assume that oxidative stress, mitochondrial defects, neuroinflammation play vital roles progress disease. current study was established to investigate neuroprotective...

Total internal reflection fluorescence microscopy (TIRF-Microscopy) allows the observation of individual secretory vesicles in real-time during exocytosis. In contrast to electrophysiological methods, such as membrane capacitance recording or carbon fiber amperometry, TIRF-Microscopy also enables they reside close plasma prior fusion. However, is limited visualization that are located near attached glass coverslip on which cell grows. This has raised concerns whether exocytosis measured with...

Cyclocreatine and its water-soluble derivative, cyclocreatine phosphate (CCrP), are potent cardioprotective drugs. Based on recent animal studies, CCrP, FDA-awarded Orphan Drug Designation, has a promising role in increasing the success rate of patients undergoing heart transplantation surgery by preserving donor hearts during transportation improving recovery transplanted recipient patients. In addition, CCrP is under investigation as treatment for creatine transporter deficiency, an...

Pyrroles and fused pyrroles are of great interest as biologically active compounds, among these activities; antidepressant activity is special concern.Synthesis a series pyrrolopyrazoles their pyrimidine derivatives characterization using spectral data to be monitored for behavioral techniques.A control group was administered the vehicle i.p., positive received fluoxetine standard all other groups were tested compounds. The subjected tail suspension test (TST) determine compared with drug....

To investigate the effect of dimethyl fumarate (DMF) on Toll-like receptor (TLR) signalling pathway in isoproterenol (ISO)-induced cardiac hypertrophy rats.Sixty adult male Sprague-Dawley rats were randomly allocated into three groups. group I: received vehicles only; II: treated with ISO (5 mg/kg per day S.C.) to induce for 7 days; and III: given DMF (25 12 h P.O.) 28 days, at last they S.C.).Pretreatment decreased heart-to-body weight ratio, heart rate blood pressure improved...

Aim: As part of ongoing studies in developing new anti-inflammatory agents, 2-thioxo-1,2,3,4-tetrahydropyrimidine derivative 1 was synthesized by direct Biginelli condensation and used for the synthesis novel series pyrimidin-2-thione derivatives (2a-d to 7a-b).
 Materials Methods: All compounds were examined their activity using carrageenan-induced rat paw edema assay comparison ibuprofen, as a reference drug. Molecular docking carried out SYBLYL-X v.2.1 software.
 Study Design: A...

Pain-associated depression is encountered clinically in some cases such as cancer, chronic neuropathy, and after operations. Tramadol an opioid analgesic drug that may modulate monoaminergic neurotransmission by inhibition of noradrenaline serotonin reuptake contribute to its antidepressant-like effects. Clinically, tramadol used either alone or combination with other NSAIDs the treatment associated pain depression, e.g. low back pain, spinal cord injury, post-operative management. However,...

NUPR1 is a transcription factor that has attracted great attention because of its various roles in cancer. Several studies were carried out to determine molecular targets and mechanism action develop novel therapies against Here, we shed light on the role different types regulates complex network pathways may be affected by silencing, which can cause varying effects. Its some cancer been reported but remains incompletely understood, whereas other cancers have not yet. Therefore, targeting...

Cancer has become the leading cause of human death in world, due to its uncontrolled and rapid proliferation properties.Radio chemotherapy are used treatment almost all types cancer.They mostly act by increasing production reactive oxygen specious (ROS) free radicals.ROS levels believed be higher cancer cells compared their normal counterparts this is suggested related cell growth, angiogenesis, metastasis.Although cure rate for many would increased radiation dose escalation, balancing...